Pilot & Feasibility Program

项目概要P/F计划 试点和可行性（P/F）计划的目标是提供一种机制， 为初级教师的研究项目，并促进消化系统疾病的职业发展。自1999年以来，第56/58号决议 奖项一直在助理教授级或更初级的研究人员（轨道1），和14/15，因为 2013.自1999年以来，P/F计划的总体投资回报率（ROI）为58：1。我们建立 一个详细和严格的同行评审过程，从申请人中选出最有价值的建议， 最大的潜力。我们确保通过电子邮件、电话和面对面的方式提供建设性的互动反馈 在申请前与所有申请人进行讨论和会议，并在审查后提出书面批评。我们 每年收到9-15份申请，其中4-5份在内部和外部审查后获得资助，并获得最终优先权 由我们的外部顾问委员会负责。具体目标该计划是广告和推广内 华盛顿大学社区有两个关键目标：目标1：提供资金，刺激创造性 帮助教师建立独立的，在消化系统疾病的校外资助计划的建议 研究，促进研究基地的扩大，并吸引新的想法消化领域 疾病整体。目标2：提供一个促进新员工职业发展的重要机制 研究人员，特别是新兴的初级教师（轨道1）。WU-DDRCC P/F计划资助初级 调查人员正处于职业生涯的关键时刻，初步数据可能意味着 成功的校外资助和建立在GI研究与追求非GI研究或其他职业生涯 职业目标完全。成就和亮点。在2003- 2018年期间（15个P/F周期）， 为43名调查员供资，投资总额为1 551 372美元（平均：36 078美元/合同）。那些P/F 获奖者反过来又获得了5980万美元的直接成本，投资回报率为39：1。上一个周期的ROI （2013-18）是26：1。95%的P/F获奖者仍在从事全职学术研究，其中72%（31/43） 获得后续独立资助（33 R 01，6 R21，4 R 03，6 K奖（1 K 01，2 K23，4 K 08），3 ACS）。 P/F资助使我们的P/F获奖者在《科学》杂志上发表了许多具有高影响力的出版物（洛拉·胡珀）， Nature（纽贝里）和Cell（Stappenbeck，Ting Wang）。仅在过去的四年里，我们的获奖者 在Nature Commun（DeBosch），Hepatology（Rudnick），Cell Host Microbe（Mysorekar， Xiaochao Wei）和Nat Methods（Ting Wang）。P/F计划由Jason米尔斯博士负责， 戴维森医生和塔尔医生一起他们一起招聘基础和临床部门的新初级候选人 在华盛顿大学，带来了相当广泛的新的，初级调查员到GI研究。以来 上一次更新，P/F获奖者来自不同的部门背景：医学（GI， 肿瘤科、血液科、传染病科、营养科、心脏科、内分泌科）、儿科（GI， 风湿病学），病理学和免疫学，发育生物学，遗传学，妇产科。

PROJECT SUMMARY P/F Program The objectives of Pilot and Feasibility (P/F) Program are to provide a mechanism for enhancing interdisciplinary research projects for junior faculty and to promote career development in digestive diseases. Since 1999, 56/58 awards have been to investigators at the Assistant Professor level or more junior (Track 1), and 14/15 since 2013. Since 1999, the P/F Program has an overall Return on Investment (ROI) of 58:1. We have established a detailed and rigorous peer-review process to select the most meritorious proposals from applicants with the greatest potential. We assure constructive and interactive feedback through email, phone and face-to-face discussions and meetings with all the applicants prior to application and written critiques following review. We receive 9-15 applications each year, with 4-5 funded following internal and external review with final priority assigned by our External Advisory Board. SPECIFIC AIMS The Program is advertised and promoted within the Washington University community with two key objectives: Aim 1: To provide funds that spur creative proposals that help faculty establish independent, extramurally funded programs in digestive disease research, facilitate expansion of the Research Base, and attract new ideas to the field of digestive disease as a whole. Aim 2: To provide a crucial mechanism to promote career development of new investigators, particularly emerging junior faculty (Track 1). The WU-DDRCC P/F Program funds junior investigators at a critical juncture in their career when preliminary data could mean the difference between successful extramural funding and building a career in GI research vs. pursuing either non-GI research or other career goals entirely. ACCOMPLISHMENTS AND HIGHLIGHTS. Between 2003-18 (15 P/F cycles), we funded 43 investigators with total investment of $1,551,372 (average: $36,078/award). Those P/F Awardees in turn have received $59.8M in total direct costs for an ROI of 39:1. Our ROI for the last cycle (2013-18) is 26:1. 95% of our P/F Awardees are still engaged in full-time academic research, with 72% (31/43) obtaining subsequent independent funding (33 R01, 6 R21, 4 R03, 6 K awards (1 K01, 2 K23, 4 K08), 3 ACS). P/F funding has led to our P/F Awardees publishing numerous high impact publications in Science (Lora Hooper), Nature (Newberry), and Cell (Stappenbeck, Ting Wang). In the last four years alone, our Awardees have published their P/F work in Nature Commun (DeBosch), Hepatology (Rudnick), Cell Host Microbe (Mysorekar, Xiaochao Wei), and Nat Methods (Ting Wang). The P/F Program is run by Dr. Jason Mills, closely coordinated with Drs. Davidson and Tarr. Together, they recruit new junior candidates across basic and clinical Departments at Washington University, bringing a considerable breadth of new, junior investigators into GI research. Since the last renewal, P/F Awardees have come from a diverse set of departmental backgrounds: Medicine (GI, Oncology, Hematology, Infectious Disease, Nutrition, Cardiology, Endocrinology Divisions), Pediatrics (GI, Rheumatology), Pathology & Immunology, Developmental Biology, Genetics, Obstetrics & Gynecology.