Pilot & Feasibility Program

飞行员

• 批准号: 10530680
• 负责人: Brian Jesse DeBosch
• 金额: $ 20.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10530680
• 关键词: Award; Cardiology; Cells; Clinical; Communicable Diseases; Communities; Creativeness; Critiques; Data; Developmental Biology; Digestive System Disorders; Direct Costs; Discipline of obstetrics; Electronic Mail; Endocrinology; Environment; Extramural Activities; Faculty; Functional disorder; Funding; Genetic; Goals; Grant; Growth and Development function; Gynecology; Hematology; Hepatology; Immunology; Interdisciplinary Study; Investments; K-Series Research Career Programs; Medicine; Methods; Microbe; Mission; Nature; Oncology; Pathology; Pediatrics; Peer Review; Philosophy; Play; Process; Publications; Publishing; Recording of previous events; Research; Research Personnel; Research Project Grants; Rheumatology; Role; Running; Science; Telephone; Universities; Washington; Work; Writing; base; career; career development; interactive feedback; meetings; nutrition; professor; programs; recruit

PROJECT SUMMARY P/F Program The objectives of Pilot and Feasibility (P/F) Program are to provide a mechanism for enhancing interdisciplinary research projects for junior faculty and to promote career development in digestive diseases. Since 1999, 56/58 awards have been to investigators at the Assistant Professor level or more junior (Track 1), and 14/15 since 2013. Since 1999, the P/F Program has an overall Return on Investment (ROI) of 58:1. We have established a detailed and rigorous peer-review process to select the most meritorious proposals from applicants with the greatest potential. We assure constructive and interactive feedback through email, phone and face-to-face discussions and meetings with all the applicants prior to application and written critiques following review. We receive 9-15 applications each year, with 4-5 funded following internal and external review with final priority assigned by our External Advisory Board. SPECIFIC AIMS The Program is advertised and promoted within the Washington University community with two key objectives: Aim 1: To provide funds that spur creative proposals that help faculty establish independent, extramurally funded programs in digestive disease research, facilitate expansion of the Research Base, and attract new ideas to the field of digestive disease as a whole. Aim 2: To provide a crucial mechanism to promote career development of new investigators, particularly emerging junior faculty (Track 1). The WU-DDRCC P/F Program funds junior investigators at a critical juncture in their career when preliminary data could mean the difference between successful extramural funding and building a career in GI research vs. pursuing either non-GI research or other career goals entirely. ACCOMPLISHMENTS AND HIGHLIGHTS. Between 2003-18 (15 P/F cycles), we funded 43 investigators with total investment of $1,551,372 (average: $36,078/award). Those P/F Awardees in turn have received $59.8M in total direct costs for an ROI of 39:1. Our ROI for the last cycle (2013-18) is 26:1. 95% of our P/F Awardees are still engaged in full-time academic research, with 72% (31/43) obtaining subsequent independent funding (33 R01, 6 R21, 4 R03, 6 K awards (1 K01, 2 K23, 4 K08), 3 ACS). P/F funding has led to our P/F Awardees publishing numerous high impact publications in Science (Lora Hooper), Nature (Newberry), and Cell (Stappenbeck, Ting Wang). In the last four years alone, our Awardees have published their P/F work in Nature Commun (DeBosch), Hepatology (Rudnick), Cell Host Microbe (Mysorekar, Xiaochao Wei), and Nat Methods (Ting Wang). The P/F Program is run by Dr. Jason Mills, closely coordinated with Drs. Davidson and Tarr. Together, they recruit new junior candidates across basic and clinical Departments at Washington University, bringing a considerable breadth of new, junior investigators into GI research. Since the last renewal, P/F Awardees have come from a diverse set of departmental backgrounds: Medicine (GI, Oncology, Hematology, Infectious Disease, Nutrition, Cardiology, Endocrinology Divisions), Pediatrics (GI, Rheumatology), Pathology & Immunology, Developmental Biology, Genetics, Obstetrics & Gynecology.

项目概要 P/F 计划 试点和可行性（P/F）计划的目标是提供一种加强跨学科的机制 初级教师的研究项目并促进消化系统疾病的职业发展。自 1999 年以来，56/58 奖项颁发给了助理教授级别或更低级别的研究人员（Track 1），自此之后的 14/15 2013 年。自 1999 年以来，P/F 计划的总体投资回报率 (ROI) 为 58:1。我们已经建立了 详细而严格的同行评审过程，以从申请人中选择最有价值的提案 最大的潜力。我们确保通过电子邮件、电话和面对面提供建设性的互动反馈 在申请前与所有申请人进行讨论和会议，并在审查后进行书面批评。我们 每年收到 9-15 份申请，其中 4-5 份经过内部和外部审查并最终优先获得资助 由我们的外部顾问委员会指定。具体目标 该计划在以下范围内进行宣传和推广： 华盛顿大学社区有两个关键目标： 目标 1：提供激发创造力的资金 帮助教师建立独立的、校外资助的消化系统疾病项目的提案 研究，促进研究基地的扩大，并吸引消化领域的新想法 疾病作为一个整体。目标2：提供促进新员工职业发展的重要机制 研究者，特别是新兴的初级教师（轨道 1）。 WU-DDRCC P/F 计划为初级学生提供资助 研究人员正处于职业生涯的关键时刻，初步数据可能意味着 成功获得校外资助并在地理标志研究领域建立职业生涯，而不是从事非地理标志研究或其他研究 完全是职业目标。成就和亮点。 2003-18 年间（15 个 P/F 周期），我们 资助了 43 名研究人员，总投资为 1,551,372 美元（平均：每项奖励 36,078 美元）。那些 P/F 获奖者则获得了 5,980 万美元的总直接成本，投资回报率为 39:1。我们上一个周期的投资回报率 (2013-18) 为 26:1。 95% 的 P/F 获奖者仍在从事全职学术研究，其中 72% (31/43) 获得后续独立资助（33 R01、6 R21、4 R03、6 K 奖项（1 K01、2 K23、4 K08）、3 ACS）。 P/F 资助使我们的 P/F 获奖者在《科学》杂志上发表了大量具有高影响力的出版物（Lora Hooper）， 自然（Newberry）和细胞（Stappenbeck，Ting Wang）。仅在过去四年中，我们的获奖者就 在 Nature Commun (DeBosch)、Hepatology (Rudnick)、Cell Host Microbe (Mysorekar) 上发表了他们的 P/F 工作 魏晓超）和 Nat Method（王婷）。 P/F 计划由 Jason Mills 博士负责管理，并进行密切协调 与博士。戴维森和塔尔。他们共同招募基础和临床部门的新初级候选人 在华盛顿大学，将大量新的初级研究人员带入胃肠道研究。自从 上一次更新，P/F 获奖者来自不同的部门背景：医学（GI、 肿瘤科、血液科、传染病科、营养科、心脏病科、内分泌科）、儿科（胃肠科、 风湿病学）、病理学与免疫学、发育生物学、遗传学、妇产科。