Imaging of human brain oxygenation and oxygen metabolism dynamics

人脑氧合和氧代谢动力学成像

• 批准号: 10528237
• 负责人: Audrey Peiwen Fan
• 金额: $ 21.32万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528237
• 关键词: Algorithms; Area; Biological Markers; Biophysics; Blood; Blood Vessels; Blood capillaries; Brain; Brain imaging; Brain scan; Cause of Death; Cerebrovascular Circulation; Cerebrum; Cessation of life; Clinical; Communities; Complex; Consumption; Data; Development; Dictionary; Disease; Fingerprint; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Gases; Human; Hybrids; Image; Imaging Device; Impairment; Joints; Kinetics; Knowledge; MRI Scans; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Metabolic; Metabolism; Methods; Modality; Modeling; Molecular; Monitor; Network-based; Neurologic; Neurosciences; Outcome; Output; Oxygen; Oxygen Consumption; Participant; Pathologic; Pathology; Patients; Pattern; Perfusion; Phase; Physiological; Physiology; Positron-Emission Tomography; Predisposition; Reference Standards; Resolution; Rest; Scanning; Signal Transduction; Site; Specificity; Stenosis; Stroke; System; Time; Tissues; Tracer; Translations; Validation; Veins; Water; Work; arterial spin labeling; base; blood oxygen level dependent; brain magnetic resonance imaging; brain tissue; cerebral oxygenation; cerebrovascular; clinical application; deoxyhemoglobin; disability; gray matter; hemodynamics; human imaging; imaging approach; imaging biomarker; improved; in vivo; innovation; kinetic model; metabolic rate; network dysfunction; neuroimaging; non-invasive imaging; novel; novel imaging technique; patient stratification; reconstruction; simulation; stroke risk; success; tissue oxygenation; tool

Abstract The human brain requires continual oxygen delivery to meet its enormous metabolic demand, and suffers devastating consequences when this oxygen supply is disrupted, as in stroke. While new endovascular treatments have shown promise to improve cerebrovascular outcomes, they are hampered by the lack of noninvasive biomarkers to stratify patients who are good candidates for these therapies. In particular, imaging of oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) is a long- recognized but unmet need in the stroke community. This project develops novel, clinically feasible tools for non-invasive oxygenation imaging, to study how the brain dynamically meets its oxygen needs and identify key pathophysiology in neurological patients. Our specific aims are (1) to enhance MRI-based reconstructions of OEF maps through novel “fingerprint matching” to microvascular voxel simulations and validation with the [15O]-oxygen gas PET reference; and (2) to develop a hybrid PET and MRI approach to rapidly image CMRO2 dynamics and its functional networks during a single resting scan. The novelty of this work lies in leveraging the unique capabilities of simultaneous PET/MRI scanners. The use of a PET/MRI system to validate and augment MRI-only methods for clinical OEF assessment with simultaneous PET scans is highly innovative. Hybrid measurements also allow for new, rapid CMRO2 imaging approaches that embody the best of each modality – fast and quantitative – to model brain functional connectivity and disease. Success of this proposal will generate novel neuroimaging tools to study brain oxygen consumption that are broadly applicable to any site with an MRI scanner. These advancements will enable use of physiological imaging biomarkers to evaluate endovascular therapies and reduce stroke risk, and enhance our fundamental neuroscience capabilities to understand the vascular underpinnings of brain function.

摘要