Administrative Core

行政和协调核心 项目摘要 拟议的U 54时空肿瘤分析中心的行政和协调核心， 指导性序贯靶向抑制剂：免疫治疗组合（ST-Analytics旨在 促进和支持来自ISB，耶鲁大学和UCLA的科学家的综合研究工作，以及我们的 外展计划，我们的试点项目和跨联盟项目。ST-Analytics的科学计划 旨在解决如何最好地利用免疫治疗/靶向治疗顺序组合， 实体瘤的临床治疗，从转移性皮肤黑色素瘤开始。这需要 汇集了临床，生物，物理，工程和计算的跨学科组合 科学家，以及最先进的多组学分析工具，同基因小鼠模型和丰富的生物储存库 高度相关的病人组织满足ST-Analytics的科学目标需要一个响应迅速的管理 结构，（i）促进和实现ST分析之间的有效沟通和资源共享 研究人员和更广泛的癌症系统生物学联盟（CSBC），（ii）建立一个高度互动的 环境，其中ST分析研究人员可以是好学生和老师的对方，（iii）促进 及时实现方案的具体目标，（四）在科学和 逻辑冲突出现，（v）通过各种机制促进我们科学工作队伍的多样性，包括 但不限于种子项目资金，推广计划，并提高对这些关键问题的认识， 我们的远程和面对面会议，以及（六）监测科学的科学完整性和稳健性， 的设计. ST分析管理核心应促进数据的自由流动，新的想法，实验 研究方案、定制试剂和机构间的生物标本。它应该建立工作 与其他资助中心的关系。它应便于临床或商业翻译和教育 外展它应该鼓励灵活的思维，以预期新的机会或意想不到的障碍。 最后，它应促进健康的自我评价环境。

Administration and Coordination Core Project Summary The administrative and coordination core of the proposed U54 Center for Spatiotemporal Tumor Analytics for Guiding Sequential Targeted Inhibitor : Immunotherapy Combinations (ST-Analytics is designed to promote and support the integrated research efforts of scientists from the ISB, Yale, and UCLA, as well as our Outreach program, our Pilot Projects and Cross-Consortium Projects. The scientific programs of ST-Analytics are designed to resolve how to best harness immunotherapy/targeted therapy sequential combinations for the treatment of solid tumors in the clinic, starting with a focus on metastatic cutaneous melanoma. This requires bringing together a cross-disciplinary mix of clinical, biological, physical, engineering, and computational scientists, as well as state-of-the-art, multiomic profiling tools, syngeneic mouse models, and a rich bio-repository of highly relevant patient tissues. Meeting the ST-Analytics scientific goals requires a responsive administrative structure that (i) promotes and enables effective communication and resource sharing between the ST-Analytics researchers and the broader Cancer Systems Biology Consortium (CSBC), (ii) establishes a highly interactive environment wherein ST-Analytics researchers can be good students and teachers of each other, (iii) promotes achieving the program specific aims in a timely manner, (iv) intervenes as early as possible when scientific and logistic conflicts arise, (v) promotes diversity in our scientific workforce through various mechanisms, including but not limited to seed project funding, outreach programs, and raising awareness of these critical issues during our remote and in-person meetings, and (vi) monitoring the scientific integrity and robustness of scientific designs. The ST-Analytics administrative CORE should facilitate the free flow of data, new ideas, experimental protocols, customized reagents, and biospecimens between the institutions. It should establish working relationships with other funded centers. It should facilitate clinical or commercial translation and educational outreach. It should encourage flexible thinking in anticipation of new opportunities or unexpected roadblocks. Finally, it should facilitate a healthy environment of self-evaluation.