Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions (The MSK-PELVIC Study)

女性慢性盆腔重叠疼痛的肌肉骨骼和盆底健康（MSK-PELVIC 研究）

• 批准号: 10527205
• 负责人: Colleen Marie Fitzgerald
• 金额: $ 22.7万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527205
• 关键词: Abdomen; Address; Adolescent; Adult; Affect; Aging; Anatomy; Anxiety; Area; Ataxia; Biomechanics; Characteristics; Chronic; Classification; Clinical; Clinical Research; Contracts; Degenerative polyarthritis; Devices; Diagnosis; Electromyography; Etiology; Exercise; Face; Female; Fibromyalgia; Future; Goals; Health; High Prevalence; Hip region structure; Hormonal; Hypersensitivity; Impaired health; Injections; Injury; Interstitial Cystitis; Intervention; Irritable Bowel Syndrome; Joint Laxity; Knowledge; Learning; Link; Longevity; Measurement; Measures; Medical; Mental Depression; Methods; Muscle; Muscle function; Musculoskeletal; Musculoskeletal Pain; Myofascial Pain Syndromes; Operative Surgical Procedures; Outcome Measure; Outcome Study; Pain; Patients; Pelvic Floor Muscle; Pelvic Girdle; Pelvic Pain; Pelvic floor structure; Peripheral; Pharmacology; Physical Examination; Physical activity; Physical therapy exercises; Physiological; Physiological Processes; Postmenopausal Osteoporosis; Postpartum Women; Pregnancy; Pregnant Women; Prevalence; Process; Provider; Public Health; Pudendal Neuralgia; Quality of life; Research; Research Personnel; Risk; Role; Sports; Surface; Treatment outcome; United States National Institutes of Health; Vertebral column; Viscera; Visceral pain; Vulvodynia; Woman; Work; base; central sensitization; chronic pain; chronic pelvic pain; clinically relevant; comparative; effectiveness clinical trial; endometriosis; evidence base; high risk men; improved; innovation; instrument; muscular structure; musculoskeletal injury; neuromuscular; neuromuscular function; new therapeutic target; novel; osteoporosis with pathological fracture; physical conditioning; pressure; response; side effect; success; tool; trigger point; ultrasound

Project Abstract Chronic pelvic pain (CPP) may affect up to a quarter of all women. Traditionally, CPP has been thought to be driven by visceral pain mechanisms such as Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS), Irritable bowel syndrome (IBS) and endometriosis. It is also established that these visceral pain conditions overlap with vulvodynia, fibromyalgia, depression, and anxiety. More recently, underlying pelvic floor myofascial (PFMP) and dyssynergia have been identified as additional overlapping CPP conditions. Prior work suggests PFMP may be a viscera-somatic response, however, PFMP as a compensatory consequence of other regional musculoskeletal (MSK) conditions has also been proposed. Indeed, across their lifespan, women face higher risks than men for a plethora of MSK injuries and chronic MSK conditions, including an increased prevalence of sports-related injuries, joint hypermobility, fibromyalgia, osteoarthritic conditions (post-menopause), and osteoporosis/osteoporosis-associated fractures. These elevated risks are thought to be due to the unique anatomic (structural), biomechanical, and hormonal factors that can be attributed to the physiologic process of pregnancy and aging. The current application aims to address the significant knowledge gap regarding the limited understanding of the neuromuscular function of the PFM in CPP as well as the role of overlapping MSK conditions and MSK health that may be influencing PFM response. The short-term goal is to examine PFM biomechanics by identifying the most precise muscle measures in women with CPP of various overlapping diagnoses compared to asymptomatic controls, along with assessing overall MSK health/physical activity. The long-term goal is to determine MSK pelvic pain mechanisms that will inform clinically relevant classification, develop evidence-based non-pharmacologic (physical therapy/exercise) treatments for women with CPP, and advance research tools in the area of PFM function and CPP as it relates to overall MSK health. Our innovative strategy combines neuromuscular measures using novel devices and validated measures in evaluating CPP, MSK health, and physical activity. Our central hypothesis is that women with CPP will demonstrate quantifiable PFM abnormalities and clinical MSK characteristics that differ from asymptomatic controls. The results from this study will have a significant public health impact with contributions of rigorous objective and comprehensive PFM and MSK methods, which will be suitable for future NIH clinical research networks/trials, to evaluate and assess the MSK contribution and potential treatment outcomes in women with CPP.

项目摘要