Mechanistic Distinctions in Female Chronic Pelvic Pain Subtypes

女性慢性盆腔疼痛亚型的机制差异

基本信息

批准号：
8738696
负责人：
Colleen Marie Fitzgerald
金额：
$ 12.42万
依托单位：
LOYOLA UNIVERSITY CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8738696
关键词：
Accounting Automobile Driving Biological Markers Brain Brain imaging Characteristics Chronic Classification Clinical Comorbidity Complex Cutaneous Diabetes Mellitus Diagnosis Dissection Electromyography Elements Etiology Female Functional Magnetic Resonance Imaging Goals Health Health Services Heart Diseases Interstitial Cystitis Intervention Investigation Joints Knowledge Malignant Neoplasms Mechanics Methods Muscle Musculoskeletal Musculoskeletal Pain Nociception Outcome Study Pain Pain Disorder Pain-Free Pattern Pelvic Girdle Pelvic Pain Pelvic floor structure Pelvis Peripheral Population Postpartum Period Pregnancy Property Psychophysics Public Health Quality of life Sensory Severities Shapes Site Symptoms System Testing Tissues United States Variant Visceral Visceral pain Vulvodynia Woman Work bladder pain central pain chronic pain chronic pelvic pain cost endometriosis improved patient population pressure public health relevance relating to nervous system transmission process

项目摘要

DESCRIPTION (provided by applicant): Chronic pain is a significant and highly prevalent health condition and women comprise a majority of all chronic pain populations, particularly persistent pelvic pain. Female chronic pelvic pain (CPP) is a rapidly growing and costly health concern, and may reflect a number of underlying pain diagnoses including endometriosis, interstitial cystitis, vulvodynia and pregnancy-related pelvic pain. The frequent comorbidities shared by these pain conditions have been attributed to the complex interplay of somatic (cutaneous and musculoskeletal), visceral, and viscero-visceral crosstalk that shapes peripheral pain transmission within the pelvic girdle. Unfortunately, many previous attempts to understand normal and pathological variants of pelvic pain have primarily focused on these types of pain in isolation rather than considering system interactions. Our long term goal is to delineate the differences between pelvic pain mechanisms critical to the understanding, classification, and treatment of these myriad pain conditions. An examination of subtypes that are predominated by prototypical somatic features compared to visceral features will be undertaken. The short term goal of this application is to examine the sensory and functional characteristics of women with postpartum pelvic pain (somatic-musculoskeletal pain) and interstitial cystitis/IC/CPP (visceral pain), compared with women without CPP. Additionally, we will initiate preliminary investigation in the central brain imaging of these CPP subtypes. Our central hypothesis is that women with varying types of CPP will demonstrate unique peripheral (sensory and functional) and central characteristics specific to their diagnoses and their underlying mechanisms. The expected outcome of this study is the delineation of the clinical and scientific assessment methods that most accurately reflect the underlying peripheral and possible central mechanisms driving CPP subtypes. The public health impact of this proposed work will be to enable clinicians to provide more timely and targeted interventions to improve the quality of life of women with CPP.

描述（由申请人提供）：慢性疼痛是一种严重且高度普遍的健康状况，女性占所有慢性疼痛种群的大多数，尤其是持续的骨盆疼痛。女性慢性骨盆疼痛（CPP）是一个快速增长且昂贵的健康问题，可能反映了许多潜在的疼痛诊断，包括子宫内膜异位症，间质性膀胱炎，外阴痛和与妊娠相关的骨盆疼痛。这些疼痛条件共享的频繁合并症已归因于体细胞（皮肤和肌肉骨骼），内脏和内脏 - 野子串扰的复杂相互作用，从而塑造了骨盆束内的外围疼痛。不幸的是，许多以前了解骨盆疼痛的正常和病理变异的尝试主要集中在孤立的这些类型的疼痛上，而不是考虑系统相互作用。我们的长期目标是描述盆腔疼痛机制之间对这些众多疼痛状况的理解，分类和治疗至关重要的差异。与内脏特征相比，对以典型的体细胞为主的亚型进行检查。与没有CPP的女性相比，该应用的短期目标是检查产后骨盆疼痛（体细胞肌肉骨骼疼痛）和间质性膀胱炎/IC/CPP（内脏疼痛）的女性的感觉和功能特征。此外，我们将在这些CPP亚型的中央大脑成像中启动初步研究。我们的中心假设是，具有不同类型CPP的妇女将表现出独特的外围（感觉和功能）和其诊断及其潜在机制的独特外围（感觉和功能）和中心特征。这项研究的预期结果是描述了临床和科学评估方法，这些方法最准确地反映了驱动CPP亚型的潜在外围和可能的中心机制。这项拟议工作的公共卫生影响将是使临床医生能够提供更及时，有针对性的干预措施，以改善CPP女性的生活质量。