The Black American United Memory & Aging Project (BA-UMAP): An examination of cognitive decline in midlife and older Black adults using remote cognitive assessments, risk factors & biomarkers

美国黑人联合记忆

• 批准号: 10526152
• 负责人: Travonia S Brown-Hughes
• 金额: $ 112.94万
• 依托单位: HAMPTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526152
• 关键词: Adult; Affect; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Assessment tool; Behavioral; Biological; Biological Factors; Biological Markers; Biomedical Research; Black American; Black Populations; Black race; Blood Vessels; Cellular Phone; Clinical; Clinical Research; Cognitive; Collection; Computers; Data; Data Collection; Dementia; Diagnosis; Diet; Discrimination; Disease; Early Diagnosis; Education and Outreach; Enrollment; Environmental Risk Factor; Etiology; Exposure to; Family; Family health status; Family history of; Fostering; Foundations; Fright; Genetic; Geography; Goals; Habits; Health; High Prevalence; Impaired cognition; Individual; Individual Differences; Inflammation; Inflammatory; Internet; Intervention; Length; Life Style; Low income; Measures; Memory; Mental Depression; Methods; Minority; Modality; Neighborhoods; Outcome; Participant; Patient Self-Report; Population; Prevalence; Privatization; Questionnaires; Recording of previous events; Reporting; Research; Risk; Risk Factors; Risk Reduction; Saliva; Salivary; Sampling; Self Efficacy; Specimen; Stigmatization; Stress; Testing; Time; Transportation; Trust; Uncertainty; Urine; Vascular Diseases; Work; aged; base; biopsychosocial factor; black men; black women; cardiometabolism; cognitive change; cognitive function; cognitive testing; cohesion; cohort; college; cost; deprivation; digital media; ethnic minority; executive function; follow-up; handheld mobile device; health disparity; health equity; health literacy; improved; indexing; individual variation; innovation; memory process; middle age; minority health; mobile application; neighborhood disadvantage; novel; novel strategies; online community; perceived discrimination; physical inactivity; preference; prevent; processing speed; prospective; protective factors; racial minority; racism; recruit; research study; resilience; sample collection; screening; social; social culture; social engagement; socioeconomics; stressor; telomere; tool

Project Summary More research on the multi-level factors impacting the higher prevalence of Alzheimer’s disease and related dementias among Black adults is critically needed. The overall goal of this project is to increase our understanding of the biopsychosocial factors that impact cognitive outcomes in a cohort of 600 longitudinally followed middle-aged and older Black adults (aged 55+). This cohort, referred to as the Black American United Memory and Aging Project (BA-UMAP), will be established and maintained remotely using an innovative online, faceless enrollment and data collection strategy, and will involve: (a) a comprehensive assessment of biopsychosocial factors through online questionnaires; (b) annual cognitive assessments, administered remotely via computer and mobile devices; (c) the remote collection of non-invasive saliva and urine samples at baseline and Year 4; and (d) the utilization and integration of digital media platforms for creating a virtual community that provides outreach and education, and fosters trust. The overall objectives of this study are to: (1) prospectively evaluate cognitive functioning and identify preferences for remote cognitive assessment modalities; (2) identify sociocultural, behavioral, and environmental factors associated with cross-sectional cognitive functioning and longitudinal cognitive decline, and (3) examine the association of acquired biological risk factors, inclusive of family and health history, and salivary and urine biomarkers, to cognitive functioning and cognitive decline. This research is a necessary step in understanding the etiology of cognitive decline in this growing population, for informing relevant intervention strategies, reducing dementia rates and disparities, and ultimately advancing health equity.

项目摘要 关于影响阿尔茨海默氏病较高患病率的多层因素的更多研究 迫切需要黑人成年人中的相关痴呆症。这个项目的总体目标是 为了增加我们对影响认知结果的生物心理社会因素的理解 在中年和年长的黑人成年人（55岁以上）的纵向纵向的队列中。这个队列， 被称为美国黑人联合记忆和衰老项目（BA-UMAP）将是 使用创新的在线，无面的注册和数据建立和维护 收集策略，并将涉及：（a）对生物心理因素的全面评估 通过在线问卷； （b）年度认知评估，通过 计算机和移动设备； （c）无创唾液和尿液样品的遥控集合 在基线和第4年； （d）数字媒体平台创建的利用率和集成 一个提供外展和教育的虚拟社区，并培养信任。总体目标 这项研究的是：（1）前瞻性评估认知功能并确定对 远程认知评估方式； （2）确定社会文化，行为和环境 与横截面认知功能和纵向认知下降相关的因素， （3）检查所获得的生物危险因素的关联，包括家庭和健康 历史，唾液和尿液生物标志物，以认知功能和认知能力下降。这 研究是理解这种不断增长的认知能力下降的病因的必要步骤 人口，以告知相关干预策略，降低痴呆率和差异， 并最终提高健康公平。