The Black American United Memory & Aging Project (BA-UMAP): An examination of cognitive decline in midlife and older Black adults using remote cognitive assessments, risk factors & biomarkers

美国黑人联合记忆

• 批准号: 10686987
• 负责人: Travonia S Brown-Hughes
• 金额: $ 101.57万
• 依托单位: HAMPTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686987
• 关键词: Acceleration; Adult; Affect; Age; Age Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Assessment tool; Behavioral; Biological; Biological Factors; Biological Markers; Biomedical Research; Black American; Black Populations; Black race; Blood Vessels; Cellular Phone; Clinical; Clinical Research; Cognitive; Collection; Computers; Data; Data Collection; Dementia; Diagnosis; Diet; Discrimination; Disease; Disparity; Early Diagnosis; Education and Outreach; Enrollment; Environmental Risk Factor; Etiology; Exposure to; Family; Family history of; Fostering; Foundations; Fright; Genetic; Geography; Goals; Habits; Health; High Prevalence; Impaired cognition; Individual; Individual Differences; Inflammation; Inflammatory; Internet; Intervention; Length; Life Style; Low income; Measures; Memory; Mental Depression; Methods; Minority; Modality; Neighborhoods; Outcome; Participant; Patient Self-Report; Population; Prevalence; Privatization; Questionnaires; Recording of previous events; Religiosity; Reporting; Research; Risk; Risk Factors; Risk Reduction; Saliva; Salivary; Sampling; Self Efficacy; Specimen; Stigmatization; Stress; Testing; Time; Transportation; Trust; Uncertainty; Urine; Vascular Diseases; Work; aged; biopsychosocial factor; black men; black women; cardiometabolism; cognitive change; cognitive function; cognitive testing; cohesion; cohort; college; cost; deprivation; digital media; ethnic minority; executive function; follow-up; handheld mobile device; health determinants; health disparity; health equity; health literacy; improved; indexing; individual variation; innovation; middle age; minority health; mobile application; neighborhood disadvantage; novel; novel strategies; online community; perceived discrimination; physical inactivity; preference; prevent; processing speed; prospective; protective factors; racial minority; racism; recruit; remote administration; remote assessment; research study; resilience factor; sample collection; screening; social; social culture; social engagement; socioeconomics; stressor; telomere; tool

Project Summary More research on the multi-level factors impacting the higher prevalence of Alzheimer’s disease and related dementias among Black adults is critically needed. The overall goal of this project is to increase our understanding of the biopsychosocial factors that impact cognitive outcomes in a cohort of 600 longitudinally followed middle-aged and older Black adults (aged 55+). This cohort, referred to as the Black American United Memory and Aging Project (BA-UMAP), will be established and maintained remotely using an innovative online, faceless enrollment and data collection strategy, and will involve: (a) a comprehensive assessment of biopsychosocial factors through online questionnaires; (b) annual cognitive assessments, administered remotely via computer and mobile devices; (c) the remote collection of non-invasive saliva and urine samples at baseline and Year 4; and (d) the utilization and integration of digital media platforms for creating a virtual community that provides outreach and education, and fosters trust. The overall objectives of this study are to: (1) prospectively evaluate cognitive functioning and identify preferences for remote cognitive assessment modalities; (2) identify sociocultural, behavioral, and environmental factors associated with cross-sectional cognitive functioning and longitudinal cognitive decline, and (3) examine the association of acquired biological risk factors, inclusive of family and health history, and salivary and urine biomarkers, to cognitive functioning and cognitive decline. This research is a necessary step in understanding the etiology of cognitive decline in this growing population, for informing relevant intervention strategies, reducing dementia rates and disparities, and ultimately advancing health equity.

项目摘要 影响阿尔茨海默病高患病率的多层次因素研究 和相关的痴呆症是非常需要的。该项目的总体目标是 增加我们对影响认知结果的生物心理社会因素的理解， 对600名中年和老年黑人成年人（55岁以上）进行纵向随访。这群人 美国黑人联合记忆和衰老项目（BA-UMAP） 使用创新的在线匿名注册和数据， （a）全面评估生物心理社会因素， （B）年度认知评估，通过远程管理， 计算机和移动的设备;（c）远程收集非侵入性唾液和尿液样本 （d）利用和整合数码媒体平台， 一个虚拟社区，提供外展和教育，并促进信任。总体目标 这项研究的目的是：（1）前瞻性地评估认知功能，并确定偏好， 远程认知评估模式;（2）识别社会文化，行为和环境 与横截面认知功能和纵向认知下降相关的因素， 以及（3）检查获得性生物危险因素的关联，包括家庭和健康 病史、唾液和尿液生物标志物与认知功能和认知能力下降的关系。这 研究是了解这种日益增长的认知能力下降的病因的必要步骤。 为相关干预战略提供信息，减少痴呆症发病率和差距， 最终促进健康公平。