Dendritic patterning by interacting extrinsic cues

通过相互作用的外部线索形成树突图案

• 批准号: 10527168
• 负责人: Wesley B Grueber
• 金额: $ 2.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527168
• 关键词: Adhesions; Automobile Driving; Axon; Behavior; Cell Communication; Cells; Cues; Dendrites; Development; Developmental Process; Drosophila genus; Ensure; Lead; Modality; Modeling; Molecular; Motor output; Nervous system structure; Neuraxis; Pattern; Positioning Attribute; Process; Resolution; Sensory; Specificity; Stimulus; System; Testing; Touch sensation; behavioral response; cohesion; developmental disease; insight; nervous system development; nervous system disorder; neural circuit; relating to nervous system; response; segregation; sensory input; somatosensory

Project Summary The targeting of axons and dendrites is essential for proper wiring of the nervous system and the expression of behavior. To understand how the nervous system is wired during development we focus on cell-cell interactions that underlie specificity in wiring the somatosensory system. Somatosensation is important for sensing touch and noxious stimuli, and for driving distinct and appropriate behavioral responses. We focus on the influence of local axon-axon interactions in circuit organization, function, and behavior. The somatosensory system of Drosophila is an excellent model to probe the cellular and molecular basis for neural circuit wiring and function. Here we focus on the developmental mechanisms that ensure robust axon segregation to different parts of the nervous system and how these patterns ensure appropriate neural circuit functioning. Many of the developmental processes under study, including axon-axon adhesion, repulsion, refinement, axon target selection, and the control of these processes by molecular cues and neural activity, are central to nervous system development in other species. We find that the positioning of somatosensory axons is highly ordered in the Drosophila central nervous system. This precise ordering appears to ensure that different qualities of sensory information are passed to correct downstream circuits and lead to appropriate behavioral responses. We propose that developing axons that are responsible for sensing different modalities engage in interactions that ensure separation of connections and distinct behaviors in response to sensory stimulation. By contrast we propose that axons of the same modality may engage in positive attractive interactions that ensure cohesion during wiring. We aim to test the developmental mechanisms that enforce the normally robust and distinct relationships between sensory input and motor output. We propose that at least part of the mechanism lies in a hierarchy of developmental axon-axon interactions between different sensory modalities and that understanding how this orderly wiring emerges will provide insights into the mechanisms by which nervous systems are patterned more generally, and how patterning might be disrupted in developmental disorders of the nervous system.

项目总结