Regulation of Cell Fate during Kidney Development and Disease
肾脏发育和疾病过程中细胞命运的调节
基本信息
- 批准号:10528346
- 负责人:
- 金额:$ 87.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-21 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAdvisory CommitteesAffectArchitectureAwardBioinformaticsBlood VesselsCardiovascular systemCell Differentiation processCell Fate ControlCellsChildChildhoodChronicChronic Kidney FailureClinical and Translational Science AwardsCollaborationsCommunitiesCountryCultural DiversityDevelopmentDiseaseEconomicsEducationEducational workshopEmbryoEndowmentEnsureEnvironmentEpigenetic ProcessFGF2 geneFacultyFamilyFosteringFundingGoalsGuidelinesHealthHematologyHomeostasisHuman ResourcesIndividualInfantInjury to KidneyInstitutionInvadedInvestigationJointsKidneyKidney DiseasesKnowledgeLaboratoriesLettersLifeMaintenanceMethodologyMinorityMinority ParticipationMissionNational Center for Advancing Translational SciencesNephrologyNewsletterNorth CarolinaOutcomeParticipantPathologyPericytesPhenotypePostdoctoral FellowPreventionPrincipal InvestigatorProceduresProcessRegulationRenal HypertensionReninRequest for ProposalsResearchResearch InstituteResearch PersonnelResearch Project GrantsResearch SupportResearch TrainingResourcesRoleScientistServicesSignal TransductionSmooth MuscleSmooth Muscle MyocytesSocietiesStressStudentsStudy SectionTNFSF15 geneTalentsTechnical ExpertiseTestingTrainingUnderrepresented MinorityUnited States National Institutes of HealthUniversitiesUrologic DiseasesVascular Smooth MuscleVirginiaWomanWorkarterioleasporinbaseclinically relevantcollaborative environmentdata repositorydesignepigenomicsfetalgraduate studenthigh schoolhypoperfusionimprovedinfancyinterdisciplinary approachinterestmesangial cellmultidisciplinarynephrogenesisnovelpostnatalprogenitorprogramspsychologicsocialstem cellssuccesssymposiumtranscriptomicsundergraduate studenturologicweb site
项目摘要
SUMMARY
The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated,
interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and
postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development
and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric
Nephrology such as the understanding of the proper development, and the structural and functional maintenance
of the kidney vasculature in health and disease. The experimental approaches range from examination of
epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the
phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the
role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and
Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and
vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes
Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center
will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs
with the objective to add new talent to the investigation of renal diseases in children. This will be done in
coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting-
edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia
Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The
Center will be supported by an Administrative Core which will allocate and distribute resources to Center
participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for
Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide
resources for support of research students, the development of repository data, workshops, seminars, and
symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in
Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to
accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved
management of infants and children with renal diseases and hypertension.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERTO Ariel GOMEZ其他文献
ROBERTO Ariel GOMEZ的其他文献
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{{ truncateString('ROBERTO Ariel GOMEZ', 18)}}的其他基金
AHA Hypertension Scientific Sessions 2023
2023 年 AHA 高血压科学会议
- 批准号:
10754445 - 财政年份:2023
- 资助金额:
$ 87.87万 - 项目类别:
Plasticity of renin cells in the kidney vasculature
肾血管系统中肾素细胞的可塑性
- 批准号:
10113595 - 财政年份:2018
- 资助金额:
$ 87.87万 - 项目类别:
Plasticity of renin cells in the kidney vasculature
肾血管系统中肾素细胞的可塑性
- 批准号:
9897536 - 财政年份:2018
- 资助金额:
$ 87.87万 - 项目类别:
Plasticity of renin cells in the kidney vasculature
肾血管系统中肾素细胞的可塑性
- 批准号:
10373943 - 财政年份:2018
- 资助金额:
$ 87.87万 - 项目类别:
Plasticity of renin cells in the kidney vasculature
肾血管系统中肾素细胞的可塑性
- 批准号:
9494764 - 财政年份:2018
- 资助金额:
$ 87.87万 - 项目类别:
Kidney development: Cell fate and precursors of disease in the young and adult
肾脏发育:年轻人和成人的细胞命运和疾病前兆
- 批准号:
9983463 - 财政年份:2017
- 资助金额:
$ 87.87万 - 项目类别:
Kidney development: Cell fate and precursors of disease in the young and adult
肾脏发育:年轻人和成人的细胞命运和疾病前兆
- 批准号:
9380458 - 财政年份:2017
- 资助金额:
$ 87.87万 - 项目类别:
Kidney development: Cell fate and precursors of disease in the young and adult
肾脏发育:年轻人和成人的细胞命运和疾病前兆
- 批准号:
10241335 - 财政年份:2017
- 资助金额:
$ 87.87万 - 项目类别:
Kidney development: Cell fate and precursors of disease in the young and adult
肾脏发育:年轻人和成人的细胞命运和疾病前兆
- 批准号:
9763557 - 财政年份:2017
- 资助金额:
$ 87.87万 - 项目类别:
Kidney development Cell fate and precursors of disease in the young and adult
肾脏发育 年轻人和成人的细胞命运和疾病前兆
- 批准号:
8730885 - 财政年份:2012
- 资助金额:
$ 87.87万 - 项目类别:
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