Regulation of Cell Fate during Kidney Development and Disease

肾脏发育和疾病过程中细胞命运的调节

基本信息

批准号：
10528346
负责人：
ROBERTO Ariel GOMEZ
金额：
$ 87.87万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-21 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10528346
关键词：
Adult Advisory Committees Affect Architecture Award Bioinformatics Blood Vessels Cardiovascular system Cell Differentiation process Cell Fate Control Cells Child Childhood Chronic Chronic Kidney Failure Clinical and Translational Science Awards Collaborations Communities Country Cultural Diversity Development Disease Economics Education Educational workshop Embryo Endowment Ensure Environment Epigenetic Process FGF2 gene Faculty Family Fostering Funding Goals Guidelines Health Hematology Homeostasis Human Resources Individual Infant Injury to Kidney Institution Invaded Investigation Joints Kidney Kidney Diseases Knowledge Laboratories Letters Life Maintenance Methodology Minority Minority Participation Mission National Center for Advancing Translational Sciences Nephrology Newsletter North Carolina Outcome Participant Pathology Pericytes Phenotype Postdoctoral Fellow Prevention Principal Investigator Procedures Process Regulation Renal Hypertension Renin Request for Proposals Research Research Institute Research Personnel Research Project Grants Research Support Research Training Resources Role Scientist Services Signal Transduction Smooth Muscle Smooth Muscle Myocytes Societies Stress Students Study Section TNFSF15 gene Talents Technical Expertise Testing Training Underrepresented Minority United States National Institutes of Health Universities Urologic Diseases Vascular Smooth Muscle Virginia Woman Work arteriole asporin base clinically relevant collaborative environment data repository design epigenomics fetal graduate student high school hypoperfusion improved infancy interdisciplinary approach interest mesangial cell multidisciplinary nephrogenesis novel postnatal progenitor programs psychologic social stem cells success symposium transcriptomics undergraduate student urologic web site

项目摘要

SUMMARY The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. This will be done in coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting- edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide resources for support of research students, the development of repository data, workshops, seminars, and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal diseases and hypertension.

概括这个“儿科肾脏学卓越中心”的总体目标是提供协调的，研究胚胎，胎儿和肾脏脉管系统发展的跨学科方法产后生活。该研究中心的主题是“调节肾脏发育过程中的细胞命运从广义上讲，拟议的研究涉及小儿临床相关性的基本问题肾脏学，例如对适当发展的理解以及结构和功能维护健康和疾病中的肾脏脉管系统。实验方法范围从检查控制细胞命运，可塑性和身份的表观遗传机制以及依据的细胞信号当体内平衡受到威胁时，会发生表型转变。项目1将调查肾素细胞祖细胞在肾动脉发育和病理学中的作用（R。ArielGomez和玛丽亚·路易莎·塞奎拉·洛佩兹（Maria Luisa Sequeira Lopez））。项目2将定义TGFB/FGF2轴如何控制肾素和血管平滑肌细胞在威胁婴儿期稳态的条件下（Patricio Ray，Agnes Swiatecka-Urban和Jennifer Charlton）。中心一般主题的飞行员和可行性项目将在整个大学，ASPN，ASN和成人肾脏病计划的全国层面上征集目的是为调查儿童肾脏疾病的调查增加新的人才。这将在与其他2个PCEN的协调以避免重叠并确保每个项目的最佳结果。一个加油单细胞表观基因组学，转录组学和生物信息学的边缘核心（Nathan Sheffield，Silvia Medrano）将为中心内外的个别实验室增加科学和技术专业知识。中心将由行政核心支持，该核心将分配和分配资源到中心参与者，通过征求和选择候选人的程序实施机会池计划飞行员和可行性奖励，维护中心网站和一个丰富 /教育计划，以提供支持研究生的资源，存储库数据，研讨会，半手和研讨会加强肾脏发育和疾病的研究。这个儿科卓越中心肾脏学具有必要的专业知识，潜水员的人力，重点，承诺和机构支持实现拟议的目标。预计卓越中心将导致改善婴儿和儿童肾脏疾病和高血压的管理。