Regulation of Cell Fate during Kidney Development and Disease

肾脏发育和疾病过程中细胞命运的调节

• 批准号: 10528346
• 负责人: ROBERTO Ariel GOMEZ
• 金额: $ 87.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528346
• 关键词: Adult; Advisory Committees; Affect; Architecture; Award; Bioinformatics; Blood Vessels; Cardiovascular system; Cell Differentiation process; Cell Fate Control; Cells; Child; Childhood; Chronic; Chronic Kidney Failure; Clinical and Translational Science Awards; Collaborations; Communities; Country; Cultural Diversity; Development; Disease; Economics; Education; Educational workshop; Embryo; Endowment; Ensure; Environment; Epigenetic Process; FGF2 gene; Faculty; Family; Fostering; Funding; Goals; Guidelines; Health; Hematology; Homeostasis; Human Resources; Individual; Infant; Injury to Kidney; Institution; Invaded; Investigation; Joints; Kidney; Kidney Diseases; Knowledge; Laboratories; Letters; Life; Maintenance; Methodology; Minority; Minority Participation; Mission; National Center for Advancing Translational Sciences; Nephrology; Newsletter; North Carolina; Outcome; Participant; Pathology; Pericytes; Phenotype; Postdoctoral Fellow; Prevention; Principal Investigator; Procedures; Process; Regulation; Renal Hypertension; Renin; Request for Proposals; Research; Research Institute; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Scientist; Services; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Societies; Stress; Students; Study Section; TNFSF15 gene; Talents; Technical Expertise; Testing; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Urologic Diseases; Vascular Smooth Muscle; Virginia; Woman; Work; arteriole; asporin; base; clinically relevant; collaborative environment; data repository; design; epigenomics; fetal; graduate student; high school; hypoperfusion; improved; infancy; interdisciplinary approach; interest; mesangial cell; multidisciplinary; nephrogenesis; novel; postnatal; progenitor; programs; psychologic; social; stem cells; success; symposium; transcriptomics; undergraduate student; urologic; web site

SUMMARY The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. This will be done in coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting- edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide resources for support of research students, the development of repository data, workshops, seminars, and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal diseases and hypertension.

概括 该“肾病学卓越儿科中心”的总体目标是提供协调一致的、 跨学科方法研究胚胎、胎儿和胎儿时期肾脏脉管系统的发育 产后生活。该研究中心的主题是“肾脏发育过程中细胞命运的调控” 和疾病。”广泛而言，拟议的研究涉及儿科临床相关的基本问题 肾病学，例如对适当发育、结构和功能维护的理解 健康和疾病中肾脏脉管系统的变化。实验方法范围从检查 控制细胞命运、可塑性和身份的表观遗传机制以及细胞信号 当生命早期体内平衡受到威胁时发生的表型转变。项目1将调查 肾素细胞祖细胞在肾小动脉的发育和病理学中的作用（R. Ariel Gomez 和 玛丽亚·路易莎·塞奎拉·洛佩兹）。项目 2 将定义 TGFb/FGF2 轴如何控制肾素和肾素的命运 血管平滑肌细胞在威胁婴儿期稳态的条件下（Patricio Ray，Agnes 斯瓦特卡-乌尔班和詹妮弗·查尔顿）。中心总体主题内的试点和可行性项目 将在全国范围内向广大大学、ASPN、ASN 和成人肾病学项目征集 目的是为儿童肾脏疾病的研究增添新的人才。这将在 与其他 2 个 PCEN 进行协调，以避免重叠并保证每个项目的最佳结果。一个切割—— 单细胞表观基因组学、转录组学和生物信息学的边缘核心（Nathan Sheffield、Silvia Medrano）将为中心内外的各个实验室增加科学和技术专业知识。这 中心将得到行政核心的支持，该核心将向中心分配和分配资源 参与者，实施机会库计划，其中包括征集和选择候选人的程序 试点和可行性奖，维护中心网站和丰富/教育计划，以提供 支持研究生的资源、存储库数据的开发、讲习班、研讨会和 研讨会旨在加强肾脏发育和疾病的研究。这个卓越的儿科中心 肾脏病学拥有必要的专业知识、多样化的人力、重点、承诺和机构支持， 完成拟议的目标。预计卓越中心将改善 患有肾脏疾病和高血压的婴儿和儿童的管理。