Regulation of Cell Fate during Kidney Development and Disease

肾脏发育和疾病过程中细胞命运的调节

• 批准号: 10528346
• 负责人: ROBERTO Ariel GOMEZ
• 金额: $ 87.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528346
• 关键词: Adult; Advisory Committees; Affect; Architecture; Award; Bioinformatics; Blood Vessels; Cardiovascular system; Cell Differentiation process; Cell Fate Control; Cells; Child; Childhood; Chronic; Chronic Kidney Failure; Clinical and Translational Science Awards; Collaborations; Communities; Country; Cultural Diversity; Development; Disease; Economics; Education; Educational workshop; Embryo; Endowment; Ensure; Environment; Epigenetic Process; FGF2 gene; Faculty; Family; Fostering; Funding; Goals; Guidelines; Health; Hematology; Homeostasis; Human Resources; Individual; Infant; Injury to Kidney; Institution; Invaded; Investigation; Joints; Kidney; Kidney Diseases; Knowledge; Laboratories; Letters; Life; Maintenance; Methodology; Minority; Minority Participation; Mission; National Center for Advancing Translational Sciences; Nephrology; Newsletter; North Carolina; Outcome; Participant; Pathology; Pericytes; Phenotype; Postdoctoral Fellow; Prevention; Principal Investigator; Procedures; Process; Regulation; Renal Hypertension; Renin; Request for Proposals; Research; Research Institute; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Scientist; Services; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Societies; Stress; Students; Study Section; TNFSF15 gene; Talents; Technical Expertise; Testing; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Urologic Diseases; Vascular Smooth Muscle; Virginia; Woman; Work; arteriole; asporin; base; clinically relevant; collaborative environment; data repository; design; epigenomics; fetal; graduate student; high school; hypoperfusion; improved; infancy; interdisciplinary approach; interest; mesangial cell; multidisciplinary; nephrogenesis; novel; postnatal; progenitor; programs; psychologic; social; stem cells; success; symposium; transcriptomics; undergraduate student; urologic; web site

SUMMARY The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. This will be done in coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting- edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide resources for support of research students, the development of repository data, workshops, seminars, and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal diseases and hypertension.

总结 这个“小儿肾脏病学卓越中心”的总体目标是提供一个协调， 跨学科的方法来研究胚胎，胎儿和 产后生活该研究中心的主题是“肾脏发育过程中细胞命运的调节 疾病”。概括地说，拟议的研究涉及儿科临床相关的基本问题。 肾脏学，如了解正常发育，以及结构和功能的维护 在健康和疾病中的肾脏血管系统。实验方法包括检查 表观遗传机制控制细胞的命运，可塑性，身份和细胞信号的基础， 在生命早期当体内平衡受到威胁时发生的表型转变。项目1将调查 肾素细胞祖细胞在肾小动脉的发育和病理中的作用（R.阿里尔·戈麦斯和 Maria Luisa塞凯拉洛佩斯）。项目2将定义TGF β/FGF 2轴如何控制肾素和血管紧张素Ⅱ的命运。 血管平滑肌细胞在威胁婴儿体内平衡的条件下（Patricio Ray，Agnes Swiatecka-Urban和Jennifer查尔顿）。中心总主题范围内的试点项目和可行性项目 将在全国范围内向大学、ASPN、成人肾脏病项目和成人肾脏病项目征集 目的是为儿童肾脏疾病的研究增添新的人才。这将在 与其他2个PCEN协调，以避免重叠，并保证每个项目的最佳结果。一个切割- 单细胞表观基因组学、转录组学和生物信息学的核心（Nathan谢菲尔德，Silvia Medrano）将为中心内外的各个实验室增加科学和技术专业知识。的 中心将得到管理核心的支持，该管理核心将向中心分配资源 参与者，实施机会池计划，并制定征求和选择候选人的程序， 试点和可行性奖，维护中心网站和丰富/教育计划，以提供 支持研究生的资源，存储库数据的开发，讲习班，研讨会， 研讨会，以加强研究肾脏发育和疾病。儿科卓越中心， 肾脏病学拥有必要的专业知识、多样化的人力资源、重点、承诺和机构支持， 实现提出的目标。预计卓越中心将改善 患有肾病和高血压的婴儿和儿童的管理。