Regulation of Cell Fate during Kidney Development and Disease

肾脏发育和疾病过程中细胞命运的调节

• 批准号: 10528346
• 负责人: ROBERTO Ariel GOMEZ
• 金额: $ 87.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528346
• 关键词: Adult; Advisory Committees; Affect; Architecture; Award; Bioinformatics; Blood Vessels; Cardiovascular system; Cell Differentiation process; Cell Fate Control; Cells; Child; Childhood; Chronic; Chronic Kidney Failure; Clinical and Translational Science Awards; Collaborations; Communities; Country; Cultural Diversity; Development; Disease; Economics; Education; Educational workshop; Embryo; Endowment; Ensure; Environment; Epigenetic Process; FGF2 gene; Faculty; Family; Fostering; Funding; Goals; Guidelines; Health; Hematology; Homeostasis; Human Resources; Individual; Infant; Injury to Kidney; Institution; Invaded; Investigation; Joints; Kidney; Kidney Diseases; Knowledge; Laboratories; Letters; Life; Maintenance; Methodology; Minority; Minority Participation; Mission; National Center for Advancing Translational Sciences; Nephrology; Newsletter; North Carolina; Outcome; Participant; Pathology; Pericytes; Phenotype; Postdoctoral Fellow; Prevention; Principal Investigator; Procedures; Process; Regulation; Renal Hypertension; Renin; Request for Proposals; Research; Research Institute; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Scientist; Services; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Societies; Stress; Students; Study Section; TNFSF15 gene; Talents; Technical Expertise; Testing; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Urologic Diseases; Vascular Smooth Muscle; Virginia; Woman; Work; arteriole; asporin; base; clinically relevant; collaborative environment; data repository; design; epigenomics; fetal; graduate student; high school; hypoperfusion; improved; infancy; interdisciplinary approach; interest; mesangial cell; multidisciplinary; nephrogenesis; novel; postnatal; progenitor; programs; psychologic; social; stem cells; success; symposium; transcriptomics; undergraduate student; urologic; web site

SUMMARY The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. This will be done in coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting- edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide resources for support of research students, the development of repository data, workshops, seminars, and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal diseases and hypertension.

摘要 这个“儿科肾脏病卓越中心”的总体目标是提供一个协调的， 跨学科方法研究胚胎、胎儿和肾脏血管的发育 出生后的生活。本研究中心的主题是《肾脏发育过程中细胞命运的调控》 和疾病。“总的来说，拟议的研究涉及儿科临床相关的基本问题。 如了解肾脏病的正确发展，以及结构和功能的维护 肾脏血管系统的健康和疾病。实验方法的范围从检查 控制细胞命运、可塑性和特性的表观遗传机制，以及潜在的细胞信号 早期生命中动态平衡受到威胁时发生的表型转变。项目1将调查 肾素细胞前体在肾小动脉发育和病理中的作用(R.Ariel Gomez和 玛丽亚·路易莎·塞奎拉·洛佩兹)。项目2将定义TGFb/FGF2轴如何控制肾素和 威胁婴儿期动态平衡的条件下的血管平滑肌细胞(Patricio Ray，Agnes Swiatecka-Urban和Jennifer Charlton)。中心总主题范围内的试点项目和可行性项目 将在全国范围内向大学、ASPN、ASN和成人肾脏病项目征集 目的是为儿童肾脏疾病的研究增添新的人才。这将在#年完成。 与其他两个PCEN协调，以避免重叠，并确保每个项目的最佳结果。一次切割- 单细胞表观基因组学、转录组学和生物信息学的边缘核心(内森·谢菲尔德，西尔维娅 Medrano)将为中心内外的各个实验室增加科学和技术专业知识。这个 中心将由一个管理核心提供支持，该核心将向中心分配和分配资源 参与者，实施机会库计划，包括征集和选择候选人的程序 试点和可行性奖，维护中心网站和丰富/教育计划，以提供 用于支持研究型学生、开发存储库数据、研讨会、研讨会和 举办研讨会，加强对肾脏发育和疾病的研究。这家儿科卓越中心位于 肾脏病具有必要的专业知识、不同的人力、重点、承诺和机构支持 完成建议的目标。预计英才中心将带来改进 患有肾脏疾病和高血压的婴儿和儿童的管理。