Kidney development: Cell fate and precursors of disease in the young and adult

肾脏发育：年轻人和成人的细胞命运和疾病前兆

• 批准号: 9380458
• 负责人: ROBERTO Ariel GOMEZ
• 金额: $ 85.01万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9380458
• 关键词: Address; Adult; Bioinformatics; Blood capillaries; Cell Fate Control; Cells; Child; Childhood; Collaborations; Cytometry; Databases; Development; Disease; Educational workshop; Electrolytes; Embryo; Epigenetic Process; Fostering; Genomics; Goals; Health; Homeostasis; Human Resources; Individual; Infant; Investigation; Kidney; Kidney Diseases; Knowledge; Laboratories; Life; Liquid substance; Longevity; Metanephric Diverticulum; Methodology; Morphogenesis; Nephrology; Nephrons; Participant; Pericytes; Phenotype; Procedures; Research; Research Support; Resources; Role; Signal Transduction; Stem cells; Students; Talents; Technical Expertise; Universities; Ureteral obstruction; Urologic Diseases; asporin; blood pressure regulation; capillary; clinically relevant; fetal; improved; injury and repair; inter-institutional; kidney medulla; nephrogenesis; postnatal; programs; regenerative; symposium; web site; young adult

The overall objective of this “Center of Excellence in Pediatric Nephrology” is to provide a coordinated, interdisciplinary, and inter-institutional approach to study the development of the kidney during embryonic, fetal and postnatal life. The main theme of this Research Center is “Kidney Development and Disease: Cell Fate and Precursors of Disease in the Young and Adult." Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of kidney morphogenesis and homeostasis in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs during kidney injury and repair. Project 1 will investigate the role of RBP-J in Cell fate of the Kidney Vasculature (Ariel Gomez, UVA). Project 2 will examine the epigenetic control of nephron progenitor cell lifespan (Samir El-Dahr, Tulane). Project 3 will explore the regenerative capacity of the kidney after ureteral obstruction and release (Maria Luisa Sequeira Lopez, UVA). Pilot and feasibility projects (PFP) within the general theme of the program will be solicited from the Universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. Examples of PFPs include: Pilot 1: Fate and function of peri-ureteric bud pericytes, and capillary development of the developing renal medulla (Jing Yu, UVA), Pilot 2 addresses the role of pannexins in the control of Blood pressure and fluid electrolyte homeostasis (Brant Isakson, UVA. Two cutting-edge Cores in Single Cell Genomics and Mass Cytometry, and Bioinformatics will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the procedures for soliciting and selecting candidates for the PFP, maintain a Center Website and an Enrichment/Educational program t o provide resources for support of research students, the development of repository data, workshops, seminars and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal and urological diseases.

该“儿科肾病卓越中心”的总体目标是提供一个协调的、 跨学科、跨机构的方法来研究胚胎、胎儿期间肾脏的发育 和产后生活。该研究中心的主题是“肾脏发育与疾病：细胞命运” 以及年轻人和成人疾病的前兆。”从广义上讲，拟议的研究涉及基础研究 儿科肾脏病学中的临床相关问题，例如对肾脏形态发生的理解 以及健康和疾病的稳态。实验方法包括表观遗传学检查 控制细胞命运、可塑性和身份的机制以及表型背后的细胞信号 肾损伤和修复过程中发生的转化。项目1将研究RBP-J在细胞中的作用 肾脏脉管系统的命运（Ariel Gomez，UVA）。项目2将检查肾单位的表观遗传控制 祖细胞寿命（Samir El-Dahr，杜兰大学）。项目3将探索肾脏的再生能力 输尿管梗阻和松解后（Maria Luisa Sequeira Lopez，UVA）。试点和可行性项目（PFP） 该计划的总体主题将向广大大学、ASPN、ASN 征集 和成人肾脏病学项目，旨在为肾脏疾病的研究增添新人才 在儿童中。 PFP 的示例包括： 试点 1：输尿管周围芽周细胞和毛细血管的命运和功能 发育中肾髓质的发育（Jing Yu，UVA），试点 2 探讨了 pannexins 在 控制血压和液体电解质稳态（Brant Isakson，UVA。两个尖端核心 单细胞基因组学、质谱细胞术和生物信息学将为 中心内外的各个实验室。该中心将得到行政核心的支持 它将向中心参与者分配和分配资源，实施征集和分配程序 选择 PFP 候选人，维护中心网站和丰富/教育计划，以 提供资源以支持研究生、存储库数据的开发、研讨会、 研讨会和座谈会，以加强肾脏发育和疾病的研究。这个儿科中心 卓越的肾脏病学拥有必要的专业知识、人力、重点、承诺和机构 支持实现拟议目标。预计卓越中心将导致 改善对患有肾脏和泌尿系统疾病的婴儿和儿童的管理。