Biostatistics and Data Management Core (BDM-Core)

生物统计和数据管理核心（BDM-Core）

• 批准号: 10532295
• 负责人: Salma Musaad
• 金额: $ 20.05万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-09 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10532295
• 关键词: Accelerometer; Area; Behavior; Biometry; Biostatistics Core; Child; Child Health; Child Nutrition; Childhood; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Cognitive; Collaborations; Collection; Communication; Consult; Data; Data Analyses; Data Element; Data Set; Data Storage and Retrieval; Databases; Development; Doctor of Philosophy; Documentation; Ensure; Epidemiology; Equation; Evaluation; Experimental Designs; Floor; Fostering; Gastroparesis; Genetic; Goals; Health; Health Sciences; Housing; Human Resources; Illinois; Individual; Information Dissemination; Institutes; Intervention; Kidney Diseases; Lead; Longitudinal cohort study; Measures; Medicine; Meta-Analysis; Methodology; Methods; Mission; Modeling; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; Nutritional Study; Obesity; Observational Study; Outcome; Outcome Measure; Phenols; Physical activity; Preparation; Procedures; Process; Program Sustainability; Protocols documentation; Psychometrics; Quality Control; Randomized Controlled Trials; Research; Research Design; Research Personnel; Resources; Role; Sample Size; Services; Sleep; Specimen; Statistical Data Interpretation; Statistical Study; Structure; System; Universities; Weight; Wood material; Youth; arm; cohort; college; cost effectiveness; data de-identification; data exchange; data harmonization; data management; data quality; demographics; design; digital; executive function; experience; improved; knowledge of results; member; obesity risk; outreach; pediatric department; preservation; programs; quality assurance; relational database; sound; sustainability framework; synergism; vaccine efficacy

The Biostatistics and Data Management Core (BDM-Core) will provide data management and analysis support to the program projects. Its services will include statistical and study design guidance, protocol preparation assistance and evaluation, statistical analysis and interpretation of results, data management and quality assurance. Housed in the Children’s Nutrition Research Center, the BDM-Core is easily accessible to all Project leads. BDM-Core personnel will consist of PhD- and MS-level biostatisticians and a database manager. The Core will handle requests for secondary data analysis within the program, and submit de-identified data to the NICHD Data and Specimen Hub. To promote synergy and cost-effectiveness within the program, the BDM-Core will collaborate with the Digital Assessment Core to facilitate the structure and variable formats in TDM and accelerometer-derived data sets for use by all projects. Collaboration with the Administrative Core will occur by contributing to its educational outreach activities, DSMB support, and sharing of pertinent information in its Electronic Management System. Cost-effectiveness will be promoted by housing a database manager to build and maintain a central REDCap database for all projects, support for scientific programming, data harmonization, dissemination of scientific and technical knowledge, results discussion and interpretation across all projects, and activities to promote long-term sustainability. BDM-Core members have expertise in assessing obesity risk and executive functioning outcomes, with years of experience in several advanced areas, such as clinical trials, non- randomized observational studies, study design and sample size estimation, longitudinal data analysis, generalized linear mixed models, multilevel structural equation modeling, causal inference, missing data.

生物统计和数据管理核心（BDM-Core）将提供数据管理和分析支持 到计划项目。其服务将包括统计和研究设计指导、方案准备 协助和评估、统计分析和结果解释、数据管理和质量 保证。 BDM-Core 位于儿童营养研究中心，所有人都可以轻松访问 项目领导。 BDM-Core 人员将由博士级和硕士级生物统计学家以及数据库管理员组成。 核心将处理程序内二次数据分析的请求，并将去识别化的数据提交给 NICHD 数据和样本中心。 为了促进该计划内的协同作用和成本效益，BDM-Core 将与 Digital 评估核心，以促进 TDM 和加速度计派生数据集中的结构和变量格式 供所有项目使用。与行政核心的合作将通过为其教育做出贡献来实现 外展活动、DSMB 支持以及在其电子管理系统中共享相关信息。 通过配备数据库管理器来构建和维护中央 REDCap，将提高成本效益 所有项目的数据库、科学规划支持、数据统一、科学传播 和技术知识、所有项目的结果讨论和解释以及促进 长期可持续性。 BDM 核心成员拥有评估肥胖风险和执行力方面的专业知识 功能成果，在多个先进领域拥有多年经验，例如临床试验、非 随机观察研究、研究设计和样本量估计、纵向数据分析、 广义线性混合模型、多级结构方程建模、因果推理、缺失数据。