Regenerative Micro-Electrode Peripheral Nerve Interface for Optimized Proprioceptive and Cutaneous specific interfacing

项目摘要 世界上每30多岁就有人截肢，约有210万人 在美国接受截肢生活。上肢截肢者传统上使用被动的，身体动力- 使用表面肌电(EMG)信号的ERED或电动假体 残肢的完整肌肉用于运动，依赖视觉和/或替代感觉 输入。高级外周神经(PN)系统接口已被提出为可行的 通过从截肢者提供自然感官反馈来改善截肢者控制的机制 感应式机器人假肢。不幸的是，目前的神经接口受到共同的CHALL- 长时间，如电极故障、信号随时间恶化以及不稳定或有问题的检测- Sory认为(“刺痛和刺痛”)仍然是一个挑战。我们的假设是我们可以 获得对躯体感觉丘脑和皮质(S1/VPL)的优越控制，这将导致 通过使用分子引导的再生周围神经来更好地控制感觉 引诱皮肤和本体感受性轴突沿着它们各自的分子线索臂 Y型再生式超薄多电极界面(Y-MG-RUMEI) 滇神经横断术。由于超薄MEI的电极表面积要小得多，所以 希望他们能提供更多的局部控制，减少大的、可能无关的轴突的兴奋 在周围神经中。此外，我们将通过以下方式利用优化微刺激(OpMiST) UMEI嵌入在Y的2个分支中，带有触摸和本体感觉的分子线索- TION，分别为。将从S1/VPL进行神经记录，以优化 外围的薄雾。 具体目标包括三个：SA1。用Y-MG-Remis实现选择性雾化 在大鼠模型中的本体感觉和皮肤管道。SA2.确定VPL/S1的可控性 通过雾化Y-MG-RUMEI感觉管建立大鼠前爪(手)截肢模型。SA3.阻止- 如果Y-MG-RUMEI允许更好的双向脑-神经-机器接口(BiBNMI)控制， 与对照相比，在没有分子指导的情况下，大鼠基于biBNMI的表现 截肢者模型。

Project Summary Every 30s, someone in the world has a limb amputated, with approximately 2.1 million people living with amputations in the U.S.A. Upper limb amputees traditionally use passive, body-pow- ered, or electrically powered prostheses that use surface Electromyographic (EMG) signals from intact muscles in the residual limb for movement and rely on visual and/or surrogate sensory input. Advanced peripheral nervous (PN) system interfaces have been proposed as a viable mechanism to improve the control by amputees by delivering naturalistic sensory feedback from sensorized robotic prosthetics. Unfortunately, current neural interfaces suffer from common chal- lenges such as electrode failure, signal deterioration over time, and unstable or problematic sen- sory percepts (“stinging and tingling”) that remain a challenge. Our Hypothesis is that we can obtain superior control over the somatosensory thalamus and cortex (S1/VPL), which will lead to more controlled sensory percepts by using molecularly guided regenerative peripheral nerve con- duits that entice cutaneous and proprioceptive axons down their respective molecularly cued arms of a Y-shaped Regenerative Ultra-thin Multi-Electrode Interface (Y-MG-RUMEI) implanted at me- dian nerve transections. As the Ultra-thin MEIs have much smaller electrode surface areas it is hoped they will offer more local control and decrease excitation of large, possible unrelated, axons in the peripheral nerve. Additionally, we will utilize optimized microstimulation (opMiSt) through UMEIs embedded in the 2 branches of the Y with their molecular cues for touch and propriocep- tion, respectively. Neural recordings will be made from the S1/VPL towards the optimization of the peripheral MiSt. Three specific aims are included: SA1. Achieve selective MiSt from Y-MG-REMEIs with Proprioceptive and Cutaneous conduits in a rat model. SA2. Determine controllability of VPL/S1 via MiSt in Y-MG-RUMEI sensory conduits in a rat forepaw (hand) amputee model. SA3. Deter- mine if Y-MG-RUMEIs allow better bidirectional Brain-Nerve-Machine Interface (biBNMI) control, as compared to control-RUMIs, without molecular guidance, based biBNMI performance in a rat amputee model.