Neurodevelopment of Emotional Interference Resistance in Adolescence to Adulthood: A Multimodal Neuroimaging Approach

项目摘要 儿童时期高度或增加的内化和外化症状的轨迹似乎相互重现 相互促进与青春期早期病理的发生和加重有关 以及成年早期。他们被认为与情绪基础神经网络的改变有关 抗干扰性--在抵抗干扰的同时保持对目标相关信息的注意的能力 从不相关的情感刺激中。尽管如此，这些神经网络在 青春期，他们的发展与情绪干预抵抗力的改善还有待于 很好的特点。检查工作记忆中对情绪分心的神经活动提供了丰富的 有关抵抗情绪干扰的时间序列的信息。情绪分心者招募一名 扩展情感视觉系统(AVS)包括枕叶-颞叶皮质、内侧颞叶 前额叶/杏仁核、腹外侧(VL)、腹内侧(Vm)和背内侧(Dm)前额叶皮质(PFC)； 调节AVS内的早期神经活动，事件相关电位的大小证明了这一点 (ERPS)(即N1、P1和LPP)。VLPFC和vmPFC及其与杏仁核的联系，由 钩束(UF)白质束在抵抗情绪干扰中起中心作用。剩下的是什么 目前尚不清楚AVS地区的发展以及AVS内部的结构和功能连接 促进抵抗情绪干扰，并有助于共同的精神病理轨迹 内化和外化障碍。我们通过以下目标解决这些问题：1)表征 青春期至成年期情绪抵抗的神经发展；2)表征 情绪分心加工过程中神经活动时间动力学的神经发育 研究情绪干预抵抗力的神经发育偏差是如何造成生活脆弱性的 应激以预测内化/外化症状的增加轨迹；以及(4)表征 多模式神经影像指标发育性变化与运动轨迹的关系 内化/外化症状。我们将招募210名10-25岁的年轻人(78%是白人，13%是黑人， 4%的亚洲人，2%的拉丁裔，3%的多种族)在加速纵向设计中，有30名参与者(50%男性/女性，2/3 基于父母对内化和/或外化障碍和电流升高的诊断，处于高风险状态 内化和/或外化症状)在每个年龄段(10-11、12-13、14-15、16-17、18-19、20-22和23- 25)每9个月纵向跟踪一次，提供五项内化和/或外化评估 症状，并每18个月提供三次神经评估。我们将使用多模式神经成像来 利用情绪延迟工作记忆研究抵抗情绪干扰的神经发育 任务。研究结果将阐明情绪干预抵抗的神经发育，并及早告知目标 旨在最大限度地加强已确定的神经网络的干预策略。

Project Summary Childhood trajectories of high or increasing internalizing and externalizing symptoms appear to mutually re- enforce one each other and be associated with the emergence and exacerbation of pathology in early adolescence and early adulthood. They have been linked with alterations in neural networks underlying emotional interference resistance—the ability to sustain attention on goal-relevant information while resisting interference from irrelevant emotional stimuli. Although, these neural networks undergo maturational changes during adolescence, their development in relation to improvements in emotional interference resistance has yet to be well characterized. Examining neural activity to emotional distracters during working memory provides rich information about the temporal sequence of emotional interference resistance. Emotional distracters recruit an extended affective visual system (AVS) comprised of the occipital-temporal cortex, medial temporal lobe/amygdala, ventrolateral (vl), ventromedial (vm), and dorsomedial (dm) prefrontal cortex (PFC); and modulate early neural activity within the AVS, as evidenced by greater magnitude of event-related potentials (ERPs) (i.e., N1, P1, and LPP). The vlPFC and vmPFC and their connections to the amygdala, facilitated by the uncinate fasciculi (UF) white matter tracts, play a central role in emotional interference resistance. What remains unclear is how development of AVS regions as well as the structural and functional connectivity within the AVS promotes emotional interference resistance and contributes to trajectories of psychopathology common to internalizing and externalizing disorders. We address these questions through the following Aims: 1) characterize the neurodevelopment of emotional interference resistance in adolescence through adulthood; 2) characterize the neurodevelopment of the temporal dynamics of neural activity during processing of emotional distracters; 3) examine how deviations in neurodevelopment of emotional interference resistance create a vulnerability to life stress to predict increasing trajectories of internalizing/externalizing symptoms; and (4) characterize relationships among developmental changes in multimodal neuroimaging indices and trajectories of internalizing/externalizing symptoms. We will recruit a sample of 210 10-25 year-olds (78% White, 13% Black, 4% Asian, 2% Latinx, 3% Multiracial) in an accelerated longitudinal design, with 30 participants (50%M/F, 2/3 at high risk based on parental diagnosis of an internalizing and/or externalizing disorder and elevated current internalizing and/or externalizing symptoms) in each age range (10-11, 12-13, 14-15, 16-17, 18-19, 20-22, and 23- 25) followed longitudinally every 9 months to provide five assessments of internalizing and/or externalizing symptoms, and every 18 months to provide three neural assessments. We will use multimodal neuroimaging to investigate the neurodevelopment of resisting emotional interference using an emotional delay working memory task. Findings will clarify neurodevelopment of emotional interference resistance and inform targeted early intervention strategies designed to maximally strengthen the identified neural networks.