Advancing Research on Mechanisms of Resilience (ARMOR): Prospective Longitudinal

背景：复原力被定义为通过多种过程成功适应的能力， 对不良事件的反应。虽然解释性模型仍处于起步阶段，但理论和经验 有证据表明，自我调节过程可能是弹性功能的基础。该提案将发展 （第一阶段，第一年），然后实施（第二阶段，第二年至第五年）一项研究的1,200名国民警卫队新兵在第一次 他们入伍两年，以确定适应（弹性）功能的模式和过程， 面对基本战斗训练（BCT）和其他不良事件。 目标：第一阶段的目标是重点规划和准备在以下领域进行的复原力纵向研究： 国民警卫队新兵包括： 1)使用先前的数据集开发统计算法， 飞行员基线数据收集程序， 确定纵向研究的入组和应答率目标的可行性，3）制定和完善 国民警卫队训练应激源暴露的情境化措施，以及4）评估可行性和 恢复力过程的神经行为标志物的可接受性。在第二阶段， 将采用一项为期四年的混合方法纵向研究来调查恢复力， 具有高和低弹性概率的参与者，2）P 1)表征潜在的 在BCT之前两年多开始的新兵适应轨迹，2）确定 促进和保护国民警卫队士兵的弹性功能的预测因素，和3）调查 自我调节的神经行为途径预测新兵的复原力轨迹。 程序和分析：在第1阶段，将使用数据集分析建立预测算法 在国民警卫队之前的研究中收集到的。BCT压力源的测量以及第2阶段的可行性 招募计划，将涉及100名国民警卫队新兵的在线调查之前，期间和立即 BCT之后通过影像学和实验室任务进行神经生物学测量的可行性和可接受性 将对10名新兵在BCT前后进行试验程序进行评估。 在第二阶段，在线自我报告症状（抑郁，焦虑，酒精或药物使用），适应性社交 将在BCT之前和之后的4个时间点收集功能，促进，保护和风险因素 1200名国民警卫队新兵增长混合模型将建立弹性和非弹性轨迹 适应性功能。Aim 2将使用轨迹的预测建模，使用在 基线和随后的时间点。在目标3中，120名新兵将完成实验室任务（农民的任务， 进行MRI时，在BCT之前和之后执行通过/不通过任务、点探针任务、性能监测任务），或 脑电图扫描分析将确定这些任务是否可以区分适应性强的新兵和非适应性强的新兵。 在目标1中建立的功能弹性轨迹。

Background: Resilience is defined as the capacity to adapt successfully through multiple processes in response to adverse events. While explanatory models are still in their infancy, theoretical and empirical evidence suggest that self-regulatory processes may underlie resilient functioning. This proposal will develop (Phase 1, Year 1) and then implement (Phase 2, Years 2-5) a study of 1,200 National Guard recruits in the first two years of their enlistment in order to identify patterns and processes of adaptive (resilient) functioning in the face of Basic Combat Training (BCT) and other adverse events. Aims: The aims for Phase 1 are focused on planning and preparing for a longitudinal study of resilience in National Guard recruits and include: 1) Use prior datasets to develop statistical algorithms for selecting ilot baseline data collection procedures to determine feasibility of enrollment and response rate targets for longitudinal study, 3) Develop and refine contextualized measures of National Guard training stressor exposure, and 4) Evaluate the feasibility and acceptability of neurobehavioral markers of resilience processes. During Phase 2, a comprehensive model of resilience will be investigated using a four-year, mixed-method, longitudinal study to participants with high and low probabilities of resilience, 2) P 1) Characterize latent trajectories of adjustment among new military recruits beginning prior to BCT over two years, 2) Identify promotive and protective predictors of resilient functioning in National Guard soldiers, and 3) Investigate neurobehavioral pathways of self-regulation predictive of resilience trajectories in new military recruits. Procedures and Analyses: In Phase 1, prediction algorithms will be established using analysis of datasets gathered in prior National Guard studies. The measurement of BCT stressors, and feasibility of Phase 2 recruitment plans, will involve online surveys of 100 National Guard recruits before, during and immediately after BCT. The feasibility and acceptability of neurobiological measures through imaging and laboratory tasks piloting procedures will be assessed with 10 recruits undergoing procedures before and after BCT. In Phase 2, on-line self-reports of symptoms (depression, anxiety, alcohol or drug use), adaptive social functioning, and promotive, protective, and risk factors will be collected before and at 4 time points after BCT with 1200 National Guard recruits. Growth mixture modeling will establish resilient and non-resilient trajectories of adaptive functioning. Aim 2 will use predictive modeling of trajectories using predictors collected during the baseline and subsequent time points. In Aim 3, 120 recruits will complete laboratory tasks (Farmer's task, go/no-go task, dot probe task, performance monitoring task) before and after BCT while undergoing MRI or EEG scans. Analyses will determine if these tasks can discriminate between recruits in the resilient vs. non- resilient trajectories of functioning established in Aim 1.