ANIMAL MODEL DEVELOPMENT AND BEHAVIORAL ASSESSMENT (AMD-BA) CORE

动物模型开发和行为评估 (AMD-BA) 核心

• 批准号: 10536647
• 负责人: Anna Csiszar
• 金额: $ 32.67万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536647
• 关键词: Address; Affect; Aging; Animal Experimentation; Animal Model; Animals; Applications Grants; Autopsy; Behavior assessment; Behavioral Assay; Biological Assay; Blood Pressure; Certification; Chronic; Chronic Disease; Cognition; Collaborations; Consultations; Core Facility; Data Analyses; Development; Disease; Equilibrium; Equipment; Exclusion Criteria; Experimental Designs; Funding; Gait; Geroscience; Goals; Growth; Imaging Techniques; Impaired cognition; Impairment; Infection; Inflammatory; Injections; Link; Maintenance; Manuscripts; Measurement; Mentors; Methods; Modeling; Modernization; Molecular; Oklahoma; Operative Surgical Procedures; Outcome; Pathologist; Phenotype; Pilot Projects; Procedures; Protocols documentation; Reproducibility; Research; Research Personnel; Resources; Rodent; Scientist; Services; Standardization; Statistical Data Interpretation; Supervision; Testing; Time; Tissue Banks; Tissues; Training; Veterinary Pathology; age related; aged; animal facility; animal model development; behavior test; cognitive function; cognitive testing; cost; design; gait examination; germ free condition; implantation; improved; innovation; investigator training; mouse model; muscle strength; novel strategies; prevent; programs; research facility; testing services; tumor

The Molecular and Cellular Geroscience CoBRE is designed to facilitate interdisciplinary Geroscience research on the OUHSC campus with the goal of developing a systematic understanding of the mechanistic links between aging and chronic disease. All the Projects in this CoBRE will use mouse models as their primary experimental platform to address the interaction between aging and the development of chronic age-related diseases. The primary objective of this Animal Model Development and Behavioral Assessment (AMD-BA) Core is to provide resources, assistance and training for 1) behavioral assessment and gait/mobility analyses, and 2) development, maintenance and phenotyping of animal models of aging and age-related chronic diseases, supporting the overall functions of the CoBRE, in a unified fashion that is not possible via other current resources. The core provides highly innovative resources for analysis of cognitive function and gait analysis. Additionally, these services will remove barriers to research that have prevented basic scientists studying age-related disease from expanding their research to Geroscience. The Core is composed of two basic components: Behavioral Assessment and Gait/Mobility Analysis and Animal Models. The specific aims are to: 1. Provide access to sophisticated state-of-the-art Specific Pathogen Free (SPF) behavioral testing facilities that allow investigators to characterize cognition and gait/mobility in animal models of aging and age-related chronic diseases. At the same time the goal is to improve current experimental paradigms and develop new procedures to enhance the efficiency and accuracy of behavioral assessments in mouse models of aging and develop novel approaches for data analysis. The AMD-BA Core will provide training for investigators and their staff in behavioral assay procedures and the use of behavior-al testing equipment as well. 2. Provide access to animal models of aging and coordinate the sharing of tissues derived from animal models of aging and manage the Geroscience animal model tissue bank. The AMD-BA Core is a unique research facility in Oklahoma. It will provide support for the PJIs in this application and pilot projects funded by the CoBRE. This Core service will greatly enhance Geroscience research in Oklahoma and contribute to further growth of the Geroscience Program.

分子和细胞老年科学 CoBRE 旨在促进跨学科老年科学 在 OUHSC 校园进行的研究，旨在系统地了解机械 衰老与慢性疾病之间的联系。本次 CoBRE 中的所有项目都将使用小鼠模型作为其 解决衰老与慢性病发展之间相互作用的主要实验平台 与年龄有关的疾病。该动物模型开发和行为的主要目标 评估（AMD-BA）核心是为1）行为评估提供资源、帮助和培训 和步态/活动性分析，2) 衰老动物模型的开发、维护和表型分析 和与年龄相关的慢性疾病，以统一的方式支持 CoBRE 的整体功能， 通过其他当前资源是不可能的。该核心为分析提供了高度创新的资源 认知功能和步态分析。此外，这些服务将消除研究障碍 阻止了研究年龄相关疾病的基础科学家将他们的研究扩展到老年科学。 核心由两个基本部分组成：行为评估和步态/移动性分析 动物模型。具体目标是： 1. 提供对复杂、最先进的特定技术的访问 无病原体 (SPF) 行为测试设施，使研究人员能够表征认知和 衰老和与年龄相关的慢性疾病动物模型的步态/活动能力。同时目标是 改进当前的实验范式并开发新的程序以提高效率和 小鼠衰老模型行为评估的准确性并开发新的数据方法 分析。 AMD-BA 核心将为研究人员及其工作人员提供行为分析方面的培训 程序以及行为测试设备的使用。 2. 提供动物模型 衰老并协调来自衰老动物模型的组织的共享并管理 老年科学动物模型组织库。 AMD-BA 核心是俄克拉荷马州的一个独特的研究机构。它将 为 PJI 在此应用程序和 CoBRE 资助的试点项目中提供支持。此核心服务 将极大地加强俄克拉荷马州的老年科学研究，并为老年科学研究的进一步发展做出贡献 程序。