ANIMAL MODEL DEVELOPMENT AND BEHAVIORAL ASSESSMENT (AMD-BA) CORE

动物模型开发和行为评估 (AMD-BA) 核心

• 批准号: 10536647
• 负责人: Anna Csiszar
• 金额: $ 32.67万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536647
• 关键词: Address; Affect; Aging; Animal Experimentation; Animal Model; Animals; Applications Grants; Autopsy; Behavior assessment; Behavioral Assay; Biological Assay; Blood Pressure; Certification; Chronic; Chronic Disease; Cognition; Collaborations; Consultations; Core Facility; Data Analyses; Development; Disease; Equilibrium; Equipment; Exclusion Criteria; Experimental Designs; Funding; Gait; Geroscience; Goals; Growth; Imaging Techniques; Impaired cognition; Impairment; Infection; Inflammatory; Injections; Link; Maintenance; Manuscripts; Measurement; Mentors; Methods; Modeling; Modernization; Molecular; Oklahoma; Operative Surgical Procedures; Outcome; Pathologist; Phenotype; Pilot Projects; Procedures; Protocols documentation; Reproducibility; Research; Research Personnel; Resources; Rodent; Scientist; Services; Standardization; Statistical Data Interpretation; Supervision; Testing; Time; Tissue Banks; Tissues; Training; Veterinary Pathology; age related; aged; animal facility; animal model development; behavior test; cognitive function; cognitive testing; cost; design; gait examination; germ free condition; implantation; improved; innovation; investigator training; mouse model; muscle strength; novel strategies; prevent; programs; research facility; testing services; tumor

The Molecular and Cellular Geroscience CoBRE is designed to facilitate interdisciplinary Geroscience research on the OUHSC campus with the goal of developing a systematic understanding of the mechanistic links between aging and chronic disease. All the Projects in this CoBRE will use mouse models as their primary experimental platform to address the interaction between aging and the development of chronic age-related diseases. The primary objective of this Animal Model Development and Behavioral Assessment (AMD-BA) Core is to provide resources, assistance and training for 1) behavioral assessment and gait/mobility analyses, and 2) development, maintenance and phenotyping of animal models of aging and age-related chronic diseases, supporting the overall functions of the CoBRE, in a unified fashion that is not possible via other current resources. The core provides highly innovative resources for analysis of cognitive function and gait analysis. Additionally, these services will remove barriers to research that have prevented basic scientists studying age-related disease from expanding their research to Geroscience. The Core is composed of two basic components: Behavioral Assessment and Gait/Mobility Analysis and Animal Models. The specific aims are to: 1. Provide access to sophisticated state-of-the-art Specific Pathogen Free (SPF) behavioral testing facilities that allow investigators to characterize cognition and gait/mobility in animal models of aging and age-related chronic diseases. At the same time the goal is to improve current experimental paradigms and develop new procedures to enhance the efficiency and accuracy of behavioral assessments in mouse models of aging and develop novel approaches for data analysis. The AMD-BA Core will provide training for investigators and their staff in behavioral assay procedures and the use of behavior-al testing equipment as well. 2. Provide access to animal models of aging and coordinate the sharing of tissues derived from animal models of aging and manage the Geroscience animal model tissue bank. The AMD-BA Core is a unique research facility in Oklahoma. It will provide support for the PJIs in this application and pilot projects funded by the CoBRE. This Core service will greatly enhance Geroscience research in Oklahoma and contribute to further growth of the Geroscience Program.

分子和细胞老年科学COBRE旨在促进跨学科的老年科学 对OUHSC校园的研究，旨在系统地了解 衰老和慢性病之间的联系。这个CobRE中的所有项目都将使用小鼠模型作为其 解决衰老与慢性病发展之间相互作用的主要实验平台 与年龄有关的疾病。本动物模型开发和行为学研究的主要目的是 评估（AMD-BA）核心是为1）行为评估提供资源，援助和培训 和步态/移动性分析，以及2）衰老动物模型的开发、维持和表型分析 和与年龄相关的慢性疾病，以统一的方式支持CoBRE的整体功能， 这是其他现有资源无法实现的。核心提供了高度创新的资源，用于分析 认知功能和步态分析。此外，这些服务将消除研究的障碍， 阻止了研究与年龄有关的疾病的基础科学家将他们的研究扩展到老年科学。 核心由两个基本组成部分组成：行为评估和步态/移动性分析， 动物模型。具体目标是：1.提供先进的专用 无病原体（SPF）行为测试设施，使研究人员能够表征认知和 在衰老和与年龄相关的慢性疾病的动物模型中的步态/移动性。与此同时，目标是 改进现有的实验范式，开发新的程序，以提高效率， 在小鼠衰老模型中进行行为评估的准确性，并开发新的数据处理方法 分析. AMD-BA核心将为研究者及其工作人员提供行为分析方面的培训 程序和行为测试设备的使用。2.提供获得动物模型的机会， 协调来自衰老动物模型的组织的共享，并管理 老年科学动物模型组织库。AMD-BA核心是俄克拉荷马州的一个独特的研究机构。它将 为PJIs在此应用程序和由CoBRE资助的试点项目中提供支持。核心服务 将大大加强俄克拉荷马州的老年科学研究，并有助于老年科学的进一步发展 程序.