ANIMAL MODEL DEVELOPMENT AND BEHAVIORAL ASSESSMENT (AMD-BA) CORE
动物模型开发和行为评估 (AMD-BA) 核心
基本信息
- 批准号:10536647
- 负责人:
- 金额:$ 32.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgingAnimal ExperimentationAnimal ModelAnimalsApplications GrantsAutopsyBehavior assessmentBehavioral AssayBiological AssayBlood PressureCertificationChronicChronic DiseaseCognitionCollaborationsConsultationsCore FacilityData AnalysesDevelopmentDiseaseEquilibriumEquipmentExclusion CriteriaExperimental DesignsFundingGaitGeroscienceGoalsGrowthImaging TechniquesImpaired cognitionImpairmentInfectionInflammatoryInjectionsLinkMaintenanceManuscriptsMeasurementMentorsMethodsModelingModernizationMolecularOklahomaOperative Surgical ProceduresOutcomePathologistPhenotypePilot ProjectsProceduresProtocols documentationReproducibilityResearchResearch PersonnelResourcesRodentScientistServicesStandardizationStatistical Data InterpretationSupervisionTestingTimeTissue BanksTissuesTrainingVeterinary Pathologyage relatedagedanimal facilityanimal model developmentbehavior testcognitive functioncognitive testingcostdesigngait examinationgerm free conditionimplantationimprovedinnovationinvestigator trainingmouse modelmuscle strengthnovel strategiespreventprogramsresearch facilitytesting servicestumor
项目摘要
The Molecular and Cellular Geroscience CoBRE is designed to facilitate interdisciplinary Geroscience
research on the OUHSC campus with the goal of developing a systematic understanding of the mechanistic
links between aging and chronic disease. All the Projects in this CoBRE will use mouse models as their
primary experimental platform to address the interaction between aging and the development of chronic
age-related diseases. The primary objective of this Animal Model Development and Behavioral
Assessment (AMD-BA) Core is to provide resources, assistance and training for 1) behavioral assessment
and gait/mobility analyses, and 2) development, maintenance and phenotyping of animal models of aging
and age-related chronic diseases, supporting the overall functions of the CoBRE, in a unified fashion that
is not possible via other current resources. The core provides highly innovative resources for analysis of
cognitive function and gait analysis. Additionally, these services will remove barriers to research that have
prevented basic scientists studying age-related disease from expanding their research to Geroscience.
The Core is composed of two basic components: Behavioral Assessment and Gait/Mobility Analysis and
Animal Models. The specific aims are to: 1. Provide access to sophisticated state-of-the-art Specific
Pathogen Free (SPF) behavioral testing facilities that allow investigators to characterize cognition and
gait/mobility in animal models of aging and age-related chronic diseases. At the same time the goal is to
improve current experimental paradigms and develop new procedures to enhance the efficiency and
accuracy of behavioral assessments in mouse models of aging and develop novel approaches for data
analysis. The AMD-BA Core will provide training for investigators and their staff in behavioral assay
procedures and the use of behavior-al testing equipment as well. 2. Provide access to animal models of
aging and coordinate the sharing of tissues derived from animal models of aging and manage the
Geroscience animal model tissue bank. The AMD-BA Core is a unique research facility in Oklahoma. It will
provide support for the PJIs in this application and pilot projects funded by the CoBRE. This Core service
will greatly enhance Geroscience research in Oklahoma and contribute to further growth of the Geroscience
Program.
分子和细胞地球科学CoBRE旨在促进跨学科的地球科学
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anna Csiszar其他文献
Anna Csiszar的其他文献
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{{ truncateString('Anna Csiszar', 18)}}的其他基金
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
化疗引起的血管性认知障碍:内皮衰老的作用
- 批准号:
10323272 - 财政年份:2021
- 资助金额:
$ 32.67万 - 项目类别:
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
化疗引起的血管性认知障碍:内皮衰老的作用
- 批准号:
10539312 - 财政年份:2021
- 资助金额:
$ 32.67万 - 项目类别:
Age-related vascular cognitive impairment: role of endothelial senescence
年龄相关的血管认知障碍:内皮衰老的作用
- 批准号:
10671650 - 财政年份:2020
- 资助金额:
$ 32.67万 - 项目类别:
Age-related vascular cognitive impairment: role of endothelial senescence
年龄相关的血管认知障碍:内皮衰老的作用
- 批准号:
10044293 - 财政年份:2020
- 资助金额:
$ 32.67万 - 项目类别:
Age-related vascular cognitive impairment: role of endothelial senescence
年龄相关的血管认知障碍:内皮衰老的作用
- 批准号:
10453694 - 财政年份:2020
- 资助金额:
$ 32.67万 - 项目类别:
Age-related vascular cognitive impairment: role of endothelial senescence
年龄相关的血管认知障碍:内皮衰老的作用
- 批准号:
10222565 - 财政年份:2020
- 资助金额:
$ 32.67万 - 项目类别:
ANIMAL MODEL DEVELOPMENT AND BEHAVIORAL ASSESSMENT (AMD-BA) CORE
动物模型开发和行为评估 (AMD-BA) 核心
- 批准号:
10077913 - 财政年份:2019
- 资助金额:
$ 32.67万 - 项目类别:
Microvascular mechanisms of neuroinflammation: role of Nrf2
神经炎症的微血管机制:Nrf2 的作用
- 批准号:
8748331 - 财政年份:2014
- 资助金额:
$ 32.67万 - 项目类别:
Vasoprotection by Caloric Restriction Mimetics in Aging
衰老过程中热量限制模拟物的血管保护作用
- 批准号:
8146105 - 财政年份:2010
- 资助金额:
$ 32.67万 - 项目类别:
Vasoprotection by Caloric Restriction Mimetics in Aging
衰老过程中热量限制模拟物的血管保护作用
- 批准号:
8320900 - 财政年份:2010
- 资助金额:
$ 32.67万 - 项目类别:
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