ANIMAL MODEL DEVELOPMENT AND BEHAVIORAL ASSESSMENT (AMD-BA) CORE

动物模型开发和行为评估 (AMD-BA) 核心

• 批准号: 10536647
• 负责人: Anna Csiszar
• 金额: $ 32.67万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536647
• 关键词: Address; Affect; Aging; Animal Experimentation; Animal Model; Animals; Applications Grants; Autopsy; Behavior assessment; Behavioral Assay; Biological Assay; Blood Pressure; Certification; Chronic; Chronic Disease; Cognition; Collaborations; Consultations; Core Facility; Data Analyses; Development; Disease; Equilibrium; Equipment; Exclusion Criteria; Experimental Designs; Funding; Gait; Geroscience; Goals; Growth; Imaging Techniques; Impaired cognition; Impairment; Infection; Inflammatory; Injections; Link; Maintenance; Manuscripts; Measurement; Mentors; Methods; Modeling; Modernization; Molecular; Oklahoma; Operative Surgical Procedures; Outcome; Pathologist; Phenotype; Pilot Projects; Procedures; Protocols documentation; Reproducibility; Research; Research Personnel; Resources; Rodent; Scientist; Services; Standardization; Statistical Data Interpretation; Supervision; Testing; Time; Tissue Banks; Tissues; Training; Veterinary Pathology; age related; aged; animal facility; animal model development; behavior test; cognitive function; cognitive testing; cost; design; gait examination; germ free condition; implantation; improved; innovation; investigator training; mouse model; muscle strength; novel strategies; prevent; programs; research facility; testing services; tumor

The Molecular and Cellular Geroscience CoBRE is designed to facilitate interdisciplinary Geroscience research on the OUHSC campus with the goal of developing a systematic understanding of the mechanistic links between aging and chronic disease. All the Projects in this CoBRE will use mouse models as their primary experimental platform to address the interaction between aging and the development of chronic age-related diseases. The primary objective of this Animal Model Development and Behavioral Assessment (AMD-BA) Core is to provide resources, assistance and training for 1) behavioral assessment and gait/mobility analyses, and 2) development, maintenance and phenotyping of animal models of aging and age-related chronic diseases, supporting the overall functions of the CoBRE, in a unified fashion that is not possible via other current resources. The core provides highly innovative resources for analysis of cognitive function and gait analysis. Additionally, these services will remove barriers to research that have prevented basic scientists studying age-related disease from expanding their research to Geroscience. The Core is composed of two basic components: Behavioral Assessment and Gait/Mobility Analysis and Animal Models. The specific aims are to: 1. Provide access to sophisticated state-of-the-art Specific Pathogen Free (SPF) behavioral testing facilities that allow investigators to characterize cognition and gait/mobility in animal models of aging and age-related chronic diseases. At the same time the goal is to improve current experimental paradigms and develop new procedures to enhance the efficiency and accuracy of behavioral assessments in mouse models of aging and develop novel approaches for data analysis. The AMD-BA Core will provide training for investigators and their staff in behavioral assay procedures and the use of behavior-al testing equipment as well. 2. Provide access to animal models of aging and coordinate the sharing of tissues derived from animal models of aging and manage the Geroscience animal model tissue bank. The AMD-BA Core is a unique research facility in Oklahoma. It will provide support for the PJIs in this application and pilot projects funded by the CoBRE. This Core service will greatly enhance Geroscience research in Oklahoma and contribute to further growth of the Geroscience Program.

分子和细胞老年科学中心旨在促进跨学科老年科学的发展 关于OUHSC校园的研究，目的是发展对机械的系统理解 衰老和慢性病之间的联系。这个Cobre中的所有项目都将使用鼠标模型作为他们的 解决衰老与慢性疾病发展相互作用的初步实验平台 与年龄有关的疾病。该动物模型开发和行为学研究的主要目标 评估(AMD-BA)的核心是为1)行为评估提供资源、帮助和培训 和步态/活动度分析，以及2)衰老动物模型的发展、维护和表型 和与年龄有关的慢性疾病，以统一的方式支持科布雷的整体职能， 通过其他现有资源是不可能的。核心提供了高度创新的资源来分析 认知功能和步态分析。此外，这些服务将消除研究的障碍， 阻止了研究年龄相关疾病的基础科学家将他们的研究扩展到老年科学。 核心由两个基本组成部分组成：行为评估和步态/机动性分析以及 动物模型。具体目标是：1.提供访问复杂的最先进的特定 无病原体(SPF)行为测试设施，允许调查人员表征认知和 衰老和老年相关慢性病动物模型中的步态/活动能力。同时我们的目标是 改进目前的实验范例，开发新的程序，以提高效率和 小鼠衰老模型中行为评估的准确性并开发新的数据处理方法 分析。AMD-BA核心将为调查人员及其工作人员提供行为分析方面的培训 程序和行为测试设备的使用。2.提供访问动物模型的途径 衰老和协调来自衰老动物模型的组织共享，并管理 老年科学动物模型组织库。AMD-BA Core是俄克拉荷马州独一无二的研究机构。会的 在这项申请和由科布雷资助的试点项目中为PJI提供支持。此核心服务 将极大地促进俄克拉荷马州老年科学研究，为老年科学的进一步发展做出贡献 程序。