The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease
运动对帕金森病丘脑底核神经活动的影响
基本信息
- 批准号:10538708
- 负责人:
- 金额:$ 20.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:Aerobic ExerciseAffectAlzheimer&aposs DiseaseAnimal ModelAnimalsAntiparkinson AgentsBasal GangliaBilateralBlindedBradykinesiaBrainClinicalDeep Brain StimulationDevelopmentDiseaseDisease ManagementDisease ProgressionDopamineElderlyElectrodesExerciseExercise PhysiologyExhibitsFrequenciesHumanImplantIndividualInterventionLong-Term EffectsModificationMotorMotor CortexMovement Disorder Society Unified Parkinson&aposs Disease Rating ScaleMulti-Institutional Clinical TrialNeuronsNeurosciencesOperative Surgical ProceduresParkinson DiseasePathway interactionsPatientsPatternPerformancePersonsPharmaceutical PreparationsRecommendationRecordsReportingRestSeminalStreamStructureStructure of subthalamic nucleusSymptomsSystemTechnologyTimeTremorUpper ExtremityWorkattenuationclinical outcome measuresdeep brain stimulatorexercise intensityexperiencegraspinsightmode of exercisemotor function improvementmotor symptomnervous system disorderneural patterningrelating to nervous systemresponsesimulation
项目摘要
PROJECT SUMMARY/ABSTRACT
Parkinson’s disease (PD) is the fastest growing neurological disease, outpacing even Alzheimer’s disease.
Aerobic exercise is universally accepted as an integral part of PD treatment, and stationary cycling in particular
has been suggested to be an ideal exercise modality for people with PD. Our seminal tandem cycling study
was the first to utilize forced exercise (FE) in human PD patients and demonstrate a 30% improvement in
clinical ratings compared to voluntary exercise (VE) at a self-selected rate. FE is a mode of high intensity
aerobic exercise originating in animal models of PD in which the voluntary pedaling rate (cadence) of exercise
is augmented, but not replaced. Aerobic exercise, including FE, has demonstrated potential as a disease-
modifying intervention; however, in order to truly examine disease-modification, the mechanism of action must
be evaluated. Hypersynchrony of motor circuits within the basal ganglia is associated with cardinal motor signs
such as bradykinesia, tremor, and rigidity in individuals with PD. Recent animal studies using FE evaluated
local field potentials (LFP) from the primary motor cortex (M1) and reported an attenuation of neural
hypersynchrony in the beta (13-35Hz) frequency band associated with improved motor function. Until now,
neural activity from the basal ganglia has been isolated to animal models or highly invasive human studies
where the deep brain stimulator (DBS) wires have been externalized. Recently, advances in DBS technology in
humans allows, for the first time, direct neural activity recording from the subthalamic nucleus (STN) of the
basal ganglia in individuals implanted with the Medtronic Percept DBS system. This project aims to record
neural activity from the STN during two modes, FE and VE, in individuals with PD. Our underlying
hypothesis is that high intensity exercise reduces STN hypersynchrony which facilitates cortico-basal
ganglia thalamocortical circuit functionality thereby improving motor function following exercise.
Fifteen PwPD who have previously undergone DBS surgery utilizing the Percept system will complete a single
FE and VE exercise session on a stationary cycle while off antiparkinsonian medication. Bilateral neural activity
of the STN will be continuously recorded for approximately 130 minutes total (pre-exercise, during FE or VE
and post-exercise) on two separate days. The MDS-UPDRS III Motor Exam and an upper extremity grip force
tracking paradigm will be used to determine motor response to exercise. While we expect improvements in
performance and attenuation in beta band activity following a single bout of FE and VE, it is hypothesized that
FE will experience superior results due to the higher cycling cadence resulting in greater beta attenuation.
项目总结/摘要
帕金森病(PD)是增长最快的神经系统疾病,甚至超过了阿尔茨海默病。
有氧运动被普遍认为是PD治疗的一个组成部分,特别是固定自行车
被认为是PD患者的理想运动方式。我们开创性的双人自行车研究
是第一个在人类PD患者中使用强迫运动(FE)的人,并证明了30%的改善,
临床评级相比,自愿运动(VE)在一个自我选择的速度。FE是一种高强度模式
有氧运动起源于PD动物模型,其中运动的自主踩踏率(节奏)
它是增强的,但不是替代的。有氧运动,包括FE,已被证明是一种潜在的疾病-
修改干预;然而,为了真正检查疾病修改,作用机制必须
被评价。基底神经节内运动回路的超同步性与主要运动体征相关
如PD患者的运动迟缓、震颤和僵硬。最近使用FE进行的动物研究评价了
局部场电位(LFP)从初级运动皮层(M1),并报告了衰减的神经
与改善的运动功能相关的β(13- 35 Hz)频带中的超同步。到现在为止,
来自基底神经节的神经活动已被分离用于动物模型或高度侵入性的人类研究
其中深部脑刺激器(DBS)导线已经被外部化。近年来,DBS技术的进步,
人类首次允许直接记录来自丘脑底核(subthalamic nucleus,缩写为丘脑底核)的神经活动。
植入Medtronic Percept DBS系统的个体的基底神经节。该项目旨在记录
PD患者在FE和VE两种模式下的脑电活动。我们的基本
假设是高强度运动减少了大脑皮层超同步性,
神经节丘脑皮质回路功能,从而改善运动后的运动功能。
15名之前使用Percept系统接受过DBS手术的PwPD将完成一次
FE和VE在停止服用抗帕金森病药物的情况下进行固定周期的运动。双侧神经活动
将连续记录大约130分钟(运动前、FE或VE期间
和运动后)在两个不同的日子。MDS-GRESS III运动检查和上肢握力
跟踪范例将用于确定运动对运动的反应。虽然我们期望在
在FE和VE的单次发作之后,β带活动的性能和衰减,假设
由于较高的循环节奏导致更大的β衰减,FE将获得更好的上级结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAY L. ALBERTS的其他文献
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{{ truncateString('JAY L. ALBERTS', 18)}}的其他基金
The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease
运动对帕金森病丘脑底核神经活动的影响
- 批准号:
10677893 - 财政年份:2022
- 资助金额:
$ 20.13万 - 项目类别:
Comprehensive Augmented Reality Testing (CART) Platform for Parkinson’s disease
帕金森病综合增强现实测试 (CART) 平台
- 批准号:
10688198 - 财政年份:2022
- 资助金额:
$ 20.13万 - 项目类别:
Comprehensive Augmented Reality Testing (CART) Platform for Parkinson’s disease
帕金森病综合增强现实测试 (CART) 平台
- 批准号:
10537035 - 财政年份:2022
- 资助金额:
$ 20.13万 - 项目类别:
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
CYCLE-AD:评估室内骑行对有阿尔茨海默病遗传风险的健康老年人延缓疾病进展的功效的随机对照试验
- 批准号:
10328952 - 财政年份:2021
- 资助金额:
$ 20.13万 - 项目类别:
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
CYCLE-AD:评估室内骑行对有阿尔茨海默病遗传风险的健康老年人延缓疾病进展的功效的随机对照试验
- 批准号:
10542444 - 财政年份:2021
- 资助金额:
$ 20.13万 - 项目类别:
Heart-Brain Retraining: Forced Aerobic exercise for Stroke Rehabilitation
心脑再训练:中风康复的强制有氧运动
- 批准号:
8525424 - 财政年份:2012
- 资助金额:
$ 20.13万 - 项目类别:
Heart-Brain Retraining: Forced Aerobic exercise for Stroke Rehabilitation
心脑再训练:中风康复的强制有氧运动
- 批准号:
8359195 - 财政年份:2012
- 资助金额:
$ 20.13万 - 项目类别:
CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)
帕金森试验的循环下肢运动(CYCLE Trial)
- 批准号:
10624440 - 财政年份:2011
- 资助金额:
$ 20.13万 - 项目类别:
The Cyclical Lower-extremity Exercise for Parkinson's Trial
帕金森氏症试验的周期性下肢运动
- 批准号:
8733774 - 财政年份:2011
- 资助金额:
$ 20.13万 - 项目类别:
The Cyclical Lower-extremity Exercise for Parkinson's Trial
帕金森氏症试验的周期性下肢运动
- 批准号:
8536966 - 财政年份:2011
- 资助金额:
$ 20.13万 - 项目类别:
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