Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)

项目摘要 “促进感染艾滋病毒妇女预防宫颈癌伙伴关系”的总体目标 改善感染艾滋病毒妇女的宫颈癌预防措施，包括增加 接受宫颈癌筛查服务，改善对筛查阳性妇女的管理， 癌前治疗结果，特别是在资源有限的环境中。研究基地成员有 建立了合作关系，有成功开展临床试验和影响临床护理的历史。作为 CASCADE研究基地，我们将为实用的临床试验提供有影响力的科学和统计方向 将在CASCADE临床研究中心进行。 我们将建立一个中央行政基础设施，以便利进行三项务实的试验。的 拟议的试验将包括一项调查的主要HPV筛查，以促进吸收宫颈癌 筛查，对筛查阳性的高危HPV女性的分流策略，以及预防性治疗， 改善宫颈癌前治疗的结果。我们还将为早期阶段提供机会 研究者在CASCADE中发展临床研究技能。 我们在实施国际临床试验和支持方面拥有管理专业知识和经验， 临床研究项目的及时实施。我们经验丰富的调查人员和我们的 拟议的试验将对CASCADE网络和消除宫颈癌的共同目标有实质性的好处。 癌症在WLWH

PROJECT ABSTRACT The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH) including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Research base members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a CASCADE Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the CASCADE Clinical Sites. We will establish a central administrative infrastructure to facilitate the conduct of three pragmatic trials. The proposed trials will include an investigation of primary HPV screening to facilitate uptake of cervical cancer screening, triage strategies for women who screen positive with high-risk HPV, and adjunctive treatment to improve outcomes to cervical pre-cancer treatments. We will also provide opportunities for early-stage investigators to develop clinical research skills within CASCADE. We have administrative expertise and experience in operationalizing international clinical trials and supporting clinical research sites in the timely implementation of projects. Our highly experienced investigators and our proposed trials will be of substantial benefit to the CASCADE network and the shared goal of eliminating cervical cancer in WLWH.