Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)

项目摘要 “推进艾滋病毒感染妇女宫颈癌预防伙伴关系”的总体目标 是改善艾滋病毒携带者(WLWH)妇女宫颈癌预防的级联，包括增加 接受宫颈癌筛查服务，改善筛查阳性妇女的管理，优化 癌症前治疗结果，特别是在资源有限的情况下。研究基地成员拥有 有成功进行临床试验和影响临床护理的历史，建立了合作关系。作为一名 梯级研究基地，我们将为务实的临床试验提供有效的科学和统计指导 将在CASCADE临床站点进行。 我们将建立中央行政基础设施，为开展三项务实试验提供便利。这个 拟议的试验将包括一项初步HPV筛查调查，以促进宫颈癌的发生。 对筛查高危HPV阳性的妇女的筛查、分流策略和辅助治疗 改善宫颈癌前治疗的结果。我们还将为早期阶段提供机会 研究人员在CASCADE中发展临床研究技能。 我们在运作国际临床试验和支持方面拥有管理专业知识和经验 在临床研究现场及时实施项目。我们经验丰富的调查人员和我们的 拟议的试验将对CASCADE网络和消除宫颈病变的共同目标有实质性好处 WLWH的癌症。

PROJECT ABSTRACT The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH) including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Research base members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a CASCADE Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the CASCADE Clinical Sites. We will establish a central administrative infrastructure to facilitate the conduct of three pragmatic trials. The proposed trials will include an investigation of primary HPV screening to facilitate uptake of cervical cancer screening, triage strategies for women who screen positive with high-risk HPV, and adjunctive treatment to improve outcomes to cervical pre-cancer treatments. We will also provide opportunities for early-stage investigators to develop clinical research skills within CASCADE. We have administrative expertise and experience in operationalizing international clinical trials and supporting clinical research sites in the timely implementation of projects. Our highly experienced investigators and our proposed trials will be of substantial benefit to the CASCADE network and the shared goal of eliminating cervical cancer in WLWH.