2nd Biennial ASBMB - BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity

摘要 在过去的几年里，理解表观遗传学和染色质是如何 国家影响DNA复制和DNA修复，这是维持基因组完整性的两个关键过程。 然而，大多数关于表观遗传学和染色质的会议都集中在转录上，而大多数关于DNA的会议 修复或DNA复制不包括对表观遗传学和染色质的关注。这次会议的主要焦点是 将是染色质之间的动态相互作用，包括组蛋白修饰和高阶染色质 结构和与基因组完整性有关的过程，包括DNA复制、DNA修复和损伤 这是唯一一次专门讨论这一问题的会议。此外，会议还强调了 在癌症和衰老细胞中，表观遗传学和基因组稳定性之间的相互作用出现了问题。因此，这 会议将弥合这一差距，将对表观遗传调控和染色质感兴趣的研究人员联系起来 那些对基因组完整性感兴趣的人。这次会议的目标是把科学家聚集在一起。 他们对表观遗传调控和基因组完整性感兴趣，一起讨论和互动。一个 主要目标是传递知识和促进基础学术研究人员之间的合作， 临床科学家和工业研究人员了解表观遗传状态如何调节基因组稳定性和 反之亦然，以及这在一系列不同的癌症和与年龄相关的疾病中是如何出错的。除 科学聚焦，我们将促进两个社会之间的互动，美国生物化学学会和 分子生物学与中国生物物理学会。第二个目标是培养 促进年轻调查人员的发展和兴趣，以帮助支持他们的职业发展。参赛者 留在会场用餐，这样他们就有充足的时间进行非正式的头脑风暴和网络交流。而当 我们有两位杰出的主旨演讲者和其他领域的领导者已经承诺发言，大多数 演讲将从提交的摘要中挑选出来，使初级科学家能够在演讲中得到强调。 此外，会议将为海报获奖者提供一个简短介绍的机会，即 对他们的职业发展很重要。我们亦会举行小组讨论，讨论专业发展和 职业选择，旨在为年轻的调查员提供进一步的支持。此外，将会有一个多样性 网络会议，以及将在会议上重点介绍的多个演讲者会议。这 会议特别及时，因为表观遗传学疗法、基因组稳定性和 癌症。2019年首届两会联席会议在苏州举行中国 来自世界各地的275名科学家参加了非常成功的会议，我们期待着举行 会议将于2022年9月28日至10月2日在美国西雅图举行。

Abstract Over the past few years, it has become increasingly important to understand how epigenetics and chromatin states impact DNA replication and DNA repair, two key processes critical for maintaining genome integrity. However, most meetings on epigenetics and chromatin focus on transcription, while most meetings on DNA repair or DNA replication include little attention to epigenetics and chromatin. The major focus of this meeting will be the dynamic interplay among chromatin, including histone modifications and high-order chromatin structure, and processes related to genome integrity, including DNA replication, DNA repair and the damage response and is the only meeting dedicated to this subject. Moreover, the meeting also highlights how the interplay between epigenetics and genome stability goes awry in cancer and aging cells. Therefore, this conference will bridge this gap to link researchers who are interested in epigenetic regulations and chromatin with those who are interested in genome integrity. The goal of this conference is to bring together scientists who are interested in epigenetic regulation and genome integrity together for discussion and interactions. A primary objective is to transfer knowledge and foster collaboration between basic academic researchers, clinical scientists, and industrial researchers to understand how epigenetic states regulate genome stability and vice versa, and how this goes awry in a diverse set of cancers and age-related diseases. In addition to the scientific focus, we will promote interactions between two societies, the American Society for Biochemistry and Molecular Biology (ASBMB) and the Biophysical Society of China (BSC). A second objective is to foster the development and interests of younger investigators to help support their career development. The participants stay and eat at the meeting venue, so they have ample time for informal brainstorming and networking. While we have two outstanding keynote speakers and other field leaders that have already committed to speak, most of the talks will be chosen from the submitted abstracts, enabling junior scientists to be highlighted in talks. Further, the meeting will provide an opportunity for poster prize winners to give a short presentation, which is important for their career development. We will also have a panel discussion on professional development and career options, aimed to provide further support for the young investigators. Moreover, there will be a diversity networking session, and multiple meet the speaker sessions that will be highlighted at the meeting. This meeting is particularly timely because of the linkage between epigenetics therapeutics, genome stability and cancer. The first joint conference of the two societies, ASBMB and BSC, was held in Suzhou, China in 2019 and was very successful attended by 275 scientists from all around the world, and we look forward to holding the conference in Seattle, WA, USA on Sept 28-Oct 2nd in 2022.