FASEB Summer Conference on Transcriptional Regulation During Cell Growth

描述(由申请者提供)：申请部分资金用于2008年6月在科罗拉多州斯诺马斯村举行的为期五天的FASEB会议“细胞生长、分化和发育过程中的转录调控”。全球分析转录因子途径和染色质修饰的能力已经彻底改变了信号转导、发育生物学和肿瘤学领域。一个新出现的主题是，染色质和DNA的表观遗传修饰伴随着基因调控的所有方面。在导致包括癌症在内的人类疾病的基因错误调控期间也是如此。然而，关于染色质的共价修饰如何影响转录机制在不同背景下的组装和拆卸，仍然存在许多基本问题。例如，对特定机制的理解对于确定肿瘤抑制基因在某些癌症中如何表观遗传失活，以及成纤维细胞如何重新编程以产生多能干细胞是至关重要的。这次会议的目的是培养新的转录方法来解决这样的问题。我们聚集了一批杰出的老牌、中级和新晋科学家，他们处于前沿，研究从基本转录机制到破译发育过程中相互作用的基因和转录因子的全球网络等各种不同的问题。这次FASE B会议在这些领域是独一无二的，因为它聚集了使用截然不同的方法来研究转录调控的科学家。会议的主要目标将是利用方法和系统的多样性来产生一个研究复杂生物系统转录的新范式。我们的哲学是，基本机制的知识为理解基因网络在发育、分化和疾病(包括癌症)过程中如何被激活和沉默提供了重要的视角。由于转录是许多调控过程的最终终点，对其机制的了解将对人类健康产生深远的影响。

DESCRIPTION (provided by applicant): Partial funding is requested for a five day FASEB conference on "Transcriptional Regulation During Cell Growth, Differentiation, and Development" to be held at Snowmass Village, Colorado in June 2008. The ability to globally analyze transcription factor pathways and chromatin modification has revolutionized the fields of signal transduction, developmental biology and oncology. An emerging theme is that epigenetic modifications of chromatin and DNA accompany all aspects of gene regulation. This is also the case during the gene misregulation that leads to human diseases including cancer. Yet many fundamental questions remain as to how covalent modifications of chromatin impact the assembly and disassembly of the transcriptional machinery in different contexts. An understanding of the specific mechanisms is central to determining, for example, how tumor suppressor genes are epigenetically inactivated in some cancers and how can a fibroblast be reprogrammed to generate a pluripotent stem cell? The purpose of this conference is to foster new transcriptional approaches to solving problems like these. We have assembled an outstanding group of established, midlevel and newly minted scientists that are at the cutting-edge, examining disparate issues ranging from fundamental mechanisms of transcription to deciphering global networks of interacting genes and transcription factors during development. This FASEB meeting is unique within these fields because it brings together scientists who employ vastly different approaches to study transcriptional regulation. The key objective of the conference will be to leverage the diversity of approaches and systems to generate a new paradigm for studying transcription in complex biological systems. Our philosophy is that knowledge of basic mechanisms provides an important perspective for understanding how networks of genes are activated and silenced during development, differentiation and disease, including cancer. As transcription is the ultimate endpoint for many regulatory processes an understanding of its mechanism will have profound implications for human health.