FASEB Summer Conference on Transcriptional Regulation During Cell Growth

描述（由申请人提供）：部分资金是要求为期五天的FASEB会议“在细胞生长，分化和发展过程中的转录调控”将于2008年6月在斯诺马斯村，科罗拉多举行。全球分析转录因子通路和染色质修饰的能力已经彻底改变了信号转导，发育生物学和肿瘤学领域。一个新兴的主题是染色质和DNA的表观遗传修饰伴随着基因调控的各个方面。这也是在基因失调导致人类疾病，包括癌症的情况。然而，许多基本的问题仍然是如何共价修饰的染色质影响组装和拆卸的转录机制在不同的情况下。理解特定的机制是确定的核心，例如，肿瘤抑制基因在某些癌症中是如何表观遗传失活的，以及成纤维细胞如何重新编程以产生多能干细胞？这次会议的目的是促进新的转录方法来解决这些问题。我们已经聚集了一群杰出的，中层和新崛起的科学家，他们处于前沿，研究不同的问题，从转录的基本机制到破译发展过程中相互作用的基因和转录因子的全球网络。这次FASEB会议在这些领域是独一无二的，因为它汇集了采用截然不同方法研究转录调控的科学家。会议的主要目标将是利用方法和系统的多样性，为复杂生物系统中的转录研究产生新的范式。我们的理念是，基本机制的知识为理解基因网络在发育，分化和疾病（包括癌症）过程中如何被激活和沉默提供了一个重要的视角。由于转录是许多调控过程的最终终点，因此对其机制的理解将对人类健康产生深远的影响。

DESCRIPTION (provided by applicant): Partial funding is requested for a five day FASEB conference on "Transcriptional Regulation During Cell Growth, Differentiation, and Development" to be held at Snowmass Village, Colorado in June 2008. The ability to globally analyze transcription factor pathways and chromatin modification has revolutionized the fields of signal transduction, developmental biology and oncology. An emerging theme is that epigenetic modifications of chromatin and DNA accompany all aspects of gene regulation. This is also the case during the gene misregulation that leads to human diseases including cancer. Yet many fundamental questions remain as to how covalent modifications of chromatin impact the assembly and disassembly of the transcriptional machinery in different contexts. An understanding of the specific mechanisms is central to determining, for example, how tumor suppressor genes are epigenetically inactivated in some cancers and how can a fibroblast be reprogrammed to generate a pluripotent stem cell? The purpose of this conference is to foster new transcriptional approaches to solving problems like these. We have assembled an outstanding group of established, midlevel and newly minted scientists that are at the cutting-edge, examining disparate issues ranging from fundamental mechanisms of transcription to deciphering global networks of interacting genes and transcription factors during development. This FASEB meeting is unique within these fields because it brings together scientists who employ vastly different approaches to study transcriptional regulation. The key objective of the conference will be to leverage the diversity of approaches and systems to generate a new paradigm for studying transcription in complex biological systems. Our philosophy is that knowledge of basic mechanisms provides an important perspective for understanding how networks of genes are activated and silenced during development, differentiation and disease, including cancer. As transcription is the ultimate endpoint for many regulatory processes an understanding of its mechanism will have profound implications for human health.