Relationship of autonomic nervous system function on functional brain networks during normal drinking and abstinence in daily drinkers

项目摘要 戒酒是饮酒经历的一个关键特征，而复发--根据定义--正在从 对消费的戒酒状态。关于生理学的许多问题在文献中仍然没有得到回答。 禁欲的机制和神经信号，以及了解这些底物对于开发 酒精使用障碍(AUD)的预防和治疗研究F99/K00提案的重点是调查 与戒酒有关的中枢和自主神经系统的影响--本质上，大脑是如何 对一段时间的强制禁欲做出反应，以及自主功能如何影响这些反应。在我们可以 了解与禁欲相关的神经过程如何有助于AUD患者的复发，我们需要 了解什么是典型的反应，以及其他健康饮酒者的潜在反应范围。 通常，检查饮酒者的生理学研究只关注大脑功能，而不考虑 中枢神经系统和外周神经系统指标之间的相互作用。这项检查自主神经系统的研究 功能，通过外周指标心率变异性(HRV)，除了检查功能的差异 日常饮酒者在一段典型饮酒期和一段时间内的脑网络组织 禁欲。通过考察这些中央和外围措施之间的关系，本研究旨在捕捉到 对戒酒相关的神经生物学有更全面的了解。 在提交本意见书时，申请人在发起人的指导下已完成所有研究 与研究相关的设计和数据收集。目前仍在对心率变异性之间的关系进行分析。 以及戒酒后酒精线索暴露期间的脑功能网络连接(F99阶段)，这将 需要分析HRV和脑网络数据的实际操作和教学培训。在F99完成后 作为这一拟议项目的一部分，这项研究将在博士后后续研究期间扩大，以纳入更高级的 脑电网络与心率变异性动态分析(K00相)。

Project Summary Alcohol abstinence is a key feature of the drinking experience, and relapse – by definition – is shifting from an abstained state to consumption. Many questions remain unanswered in the literature regarding the physiological mechanisms and neural signatures of abstinence, and understanding these substrates will be essential for developing prevention and treatment studies for Alcohol Use Disorders (AUD). The focus of the F99/K00 proposal is an investigation of central and autonomic nervous system effects associated with alcohol abstinence – in essence, how the brain responds to a period of imposed abstinence and how autonomic function impacts those responses. Before we can understand how neural processes associated with abstinence contribute to relapse in AUD patients, we need to understand what comprises a typical response, and the range of potential responses in otherwise healthy drinkers. Typically, physiological research examining alcohol drinkers focuses solely on brain function, discounting the interplay between central and peripheral nervous system measures. This study examining autonomic nervous system function, through the peripheral metric Heart Rate Variability (HRV), in addition to examine differences in functional brain network organization in everyday drinkers during a period of typical alcohol consumption and a period of abstinence. By examining the relationship between these central and peripheral measures, this study aims to capture a more complete understanding of the neurobiology associated with alcohol abstinence. At the time of this submission, the applicant, under the guidance of the sponsor, has completed all research design and data collection relevant to the study. Still remaining are analyses investigating the relationship between HRV and functional brain network connectivity during alcohol cue exposure following abstinence (F99 Phase), which will require hands‐on and didactic training analyzing HRV and brain network data. Following the completion of the F99 portion of this proposed project, the study will be expanded during a postdoctoral following to include more advanced analyses of brain network and HRV dynamics (K00 Phase).