Modular Adaptive Virtual Reality Intervention for Clinical Substance use disorder (MAVRICS)

临床药物使用障碍的模块化自适应虚拟现实干预 (MAVRICS)

• 批准号: 10542645
• 负责人: Michelle (Micki) E Washburn
• 金额: $ 5.5万
• 依托单位: INNATEVR, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542645
• 关键词: Acute; Address; Ambulatory Care; Behavior Therapy; Behavioral; Child Welfare; Chronic; Client; Clinical; Computer software; Cues; Custom; Emergency Care; Environment; Exposure to; HIV Infections; HIV/HCV; Impairment; Individual; Intervention; Interview; Justice; Left; Mental Health; Methods; Neonatal Abstinence Syndrome; Probability; Public Health; Relapse; Research; Residential Treatment; Risk; Series; Software Tools; Substance Use Disorder; System; Testing; Time; Update; base; craving; design; disorder later incidence prevention; experience; improved; mortality; novel; opioid use disorder; physical conditioning; premature; programs; substance misuse; substance use; virtual; virtual environment; virtual reality; virtual reality intervention

PROJECT SUMMARY/ABSTRACT Opioid Use Disorder (OUD) is a chronic, recurring condition that if left untreated, poses a significant and ongoing public health threat. OUD is associated with significant impairments in physical and psychological health including increased mortality and high utilization of emergency medical care as well as increased risk of Hepatitis C and HIV infection and Neonatal Abstinence Syndrome (NAS). OUD is also associated with increased justice and child welfare systems involvement. Currently, the number of empirically supported behavioral interventions for the treatment of OUDs is limited, the majority of which cannot be tailored (customized) to meet the unique needs of the individual client. As such, the relapse rate for individuals with OUDs remains high. Virtual reality cue exposure (VRCE) has shown considerable promise in addressing substance craving, one of the most salient components of OUD. Through repeated exposure to substance use cues within a controlled virtual environment, over time these virtual exposures weaken the relationship between substance use cues and craving, potentially leading to decreased substance use and lower probability of substance relapse. Unfortunately, currently available commercial VR products lack the essential ability to easily and repeatedly update exposure environments to introduce novelty or incorporate new or evolving substance use cues. This limitation results in less user engagement over time, potentially leading to user disengagement and premature treatment termination. Through the R41 project titled “Modular Adaptive Virtual Reality Intervention for Clinical Substance use disorder (MAVRICS)”, the research aims to improve upon currently available commercial virtual reality (VR) products designed to address substance misuse by developing a novel subscription-based software product (Helix) that supports ongoing customization of virtual reality-based cue exposure (VRCE) environments resulting in a tailored intervention addressing substance craving. Through the I-Corp program, the commercial potential for Helix will be further explored and five hypotheses pertaining to various commercial aspect of Helix will be tested through a series of interviews with potential customers and experts in the field of OUD treatment.

项目总结/摘要 阿片类药物使用障碍（OUD）是一种慢性、复发性疾病，如果不加以治疗， 和持续的公共健康威胁。OUD与身体和精神方面的严重损害有关。 心理健康，包括死亡率增加和紧急医疗服务利用率高，以及 丙型肝炎和艾滋病毒感染以及新生儿禁欲综合征（NAS）的风险增加。OUD也是 与司法和儿童福利系统的参与增加有关。目前，根据经验， 用于治疗OUD的支持性行为干预是有限的，其中大多数无法定制 （定制）以满足个别客户的独特需求。因此，患有这种疾病的人的复发率 OUD仍然很高。 虚拟现实提示曝光（VRCE）在解决物质渴望方面表现出相当大的希望， OUD最重要的组成部分。通过在受控环境中反复暴露于物质使用线索， 随着时间的推移，这些虚拟暴露会削弱物质使用线索之间的关系， 和渴望，可能导致减少物质使用和降低物质复发的可能性。 不幸的是，目前可用的商业VR产品缺乏简单和重复的基本能力， 更新暴露环境，以引入新奇或纳入新的或不断发展的物质使用线索。这 随着时间的推移，限制导致用户参与度降低，可能导致用户脱离和过早 治疗终止。 通过R41项目题为“模块化自适应虚拟现实干预临床物质的使用” 该研究旨在改善目前可用的商业虚拟现实（VR） 旨在通过开发基于订阅的新型软件产品来解决药物滥用问题的产品 （Hacker），支持基于虚拟现实的提示曝光（VRCE）环境的持续定制 从而导致针对物质渴望的定制干预。通过I-Corp计划， 将进一步探索HPLOS的潜力，并提出与HPLOS的各种商业方面有关的五个假设 将通过与OUD治疗领域的潜在客户和专家进行一系列访谈进行测试。