Development of a cloud-based network of smartwatch applications to improve cardiopulmonary resuscitation during cardiac arrest response.

项目摘要 在美国，每年估计有53万成年人死于心脏骤停。死亡率非常高- 90%用于院外事件，75%用于院内事件-并且十多年来一直保持不变。 早期高质量的心肺复苏术（CPR）是最重要的挽救生命的干预， 心脏骤停需要高度功能化的即时护理工具来1）在心脏检查期间协助从业者， 逮捕反应，2）允许在现场环境中进行定期培训，以及3）实现数据丰富的性能集中 同行汇报在我们的同品种SBIR I期提案中，XiMiO Health，Inc.建议开发第一个 支持智能手表的基本生命支持（BLS）应用程序，用于培训和临床响应-系统 我们称之为中继响应。我们的第一个具体目标是设计一个具有实时决策支持的BLS应用程序， 美国心脏协会（AHA）协议和实时CPR深度和速率性能反馈。到 为了实现这一目标，我们建议开发一个具有直观用户界面的应用程序， 深度和速率反馈来自一种新算法，该算法根据加速度计传感器数据计算深度和速率。 此外，我们建议开发一个基于云的数据库，与我们的BLS应用程序链接，以实现实时数据 在应对心脏骤停的救援人员之间共享。不久，我们将开始台架测试， 我们的BLS应用程序按预期运行的概念验证。我们的第二个具体目标是测试 我们的BLS应用程序在心肺复苏术模拟研究中的应用这项研究将包括30名参与者， 经验（医院内提供者，EMT和非认证人员），使用CPR人体模型建立 BLS应用程序作为CPR辅助工具的性能和实用性的概念验证。我们的研究正在按计划进行， 从2022年Q1开始。通过I-Corps计划，该团队的目标是验证和描述我们的 BLS应用程序的滩头阵地市场-包括开发购买角色、价值主张、定价 模型和销售流程。我们希望我们的成功，在表征我们的滩头市场在我军 该计划将使我们能够建立早期的商业客户和销售渠道合作伙伴关系。另夕h 我们成功完成I-Corps计划所带来的商业牵引力将减少 商业风险，机构投资者，并将加快我们吸引风险资本的能力。最终我们 我相信，我们的成功将为我们的SBIR第二阶段申请提供强有力的支持，我们预计将提交 2022年第二季度。

Project Summary Each year, an estimated 530,000 adults die of cardiac arrest in the USA. Mortality rates are excessively high – 90% for out-of-hospital events and 75% for in-hospital events – and have remained unchanged for over a decade. Early high-quality cardiopulmonary resuscitation (CPR) is the most critical lifesaving intervention for a patient in cardiac arrest. There is a need for highly functioning point-of-care tools to 1) assist practitioners during a cardiac arrest response, 2) allow for regular training in in-situ settings, and 3) enable data-rich performance-focused peer debriefing. In our predicate SBIR Phase I proposal, XiMiO Health, Inc. proposed developing the first smartwatch-enabled Basic Life Support (BLS) application for use in both training and clinical response - a system we call Relay Response. Our first specific aim was to design a BLS App with real-time decision support to American Heart Association (AHA) protocols and real-time CPR depth and rate performance feedback. To accomplish this, we proposed developing an app with an intuitive user interface capable of displaying real-time depth and rate feedback from a novel algorithm that calculates depth and rate from accelerometer sensor data. Additionally, we proposed developing a cloud-based database linked to our BLS App to enable real-time data sharing between rescuers responding to a cardiac arrest. Shortly, we will begin benchtop testing to demonstrate proof-of-concept that our BLS App performs as intended. Our second specific aim was to test the feasibility of our BLS App in a CPR simulation study. The study will include 30 participants with a wide range of CPR experience (in-hospital providers, EMTs, and noncertified personnel), using CPR manikins to establish proof-of- concept validation of the BLS App’s performance and utility as a CPR aid. Our study is on schedule and will commence in Q1 2022. With the I-Corps program, the Team’s objective is to validate and characterize our beachhead market for the BLS App – inclusive of developing buying personas, value propositions, pricing models, and sales processes. We expect our success in characterizing our beachhead market during the I-Corps program will allow us to establish early commercial customers and sales channel partnerships. Additionally, the commercial traction that will result from us successfully completing the I-Corps program will reduce the commercial risk to institutional investors and will accelerate our ability to attract venture capital. Ultimately, we believe our success will provide strong support to our SBIR Phase II application, which we anticipate submitting in Q2 2022.