Development of a cloud-based network of smartwatch applications to improve cardiopulmonary resuscitation during cardiac arrest response.

项目摘要 据估计，美国每年有53万成年人死于心脏骤停。死亡率过高-- 90%用于院外活动，75%用于院内活动--十多年来一直保持不变。 早期高质量心肺复苏(CPR)是最关键的挽救生命的干预措施 心脏骤停。在心脏手术期间，需要高功能的护理点工具来帮助从业者 逮捕反应，2)允许在现场环境中进行定期培训，以及3)实现以数据丰富的业绩为重点 同行汇报。在我们的谓词SBIR第一阶段提案中，希妙健康公司建议开发第一个 支持智能手表的基本生命支持(BLS)应用程序，用于培训和临床响应-系统 我们称之为接力响应。我们的第一个具体目标是设计一个具有实时决策支持的BLS应用程序 美国心脏协会(AHA)协议和实时CPR深度和心率性能反馈。至 为了做到这一点，我们建议开发一个具有直观用户界面的应用程序，能够实时显示 深度和速率反馈来自一种新的算法，该算法根据加速度计传感器数据计算深度和速率。 此外，我们建议开发一个链接到我们的BLS应用程序的基于云的数据库，以实现实时数据 在应对心脏骤停的救援人员之间分享。不久，我们将开始进行桌面测试，以演示 我们的BLS应用程序按预期执行的概念验证。我们的第二个具体目标是测试 我们的BLS应用程序正在进行CPR模拟研究。这项研究将包括30名接受过广泛心肺复苏的参与者 经验(住院提供者、急救人员和未经认证的人员)，使用CPR人体模型建立证据- BLS应用程序作为CPR辅助工具的性能和实用程序的概念验证。我们的研究正在如期进行，并将 于2022年第一季度开始。通过i-Corps计划，团队的目标是验证和描述我们的 BLS应用程序的滩头市场-包括开发购买角色、价值主张、定价 模型和销售流程。我们期待着在i-Corps期间成功地描述我们的滩头市场 该计划将使我们能够建立早期商业客户和销售渠道合作伙伴关系。此外， 我们成功完成i-Corps计划将带来的商业吸引力将减少 这将给机构投资者带来商业风险，并将加快我们吸引风险资本的能力。最终，我们 我相信我们的成功将为我们的SBIR第二阶段申请提供强有力的支持，我们预计将提交 在2022年第二季度。

Project Summary Each year, an estimated 530,000 adults die of cardiac arrest in the USA. Mortality rates are excessively high – 90% for out-of-hospital events and 75% for in-hospital events – and have remained unchanged for over a decade. Early high-quality cardiopulmonary resuscitation (CPR) is the most critical lifesaving intervention for a patient in cardiac arrest. There is a need for highly functioning point-of-care tools to 1) assist practitioners during a cardiac arrest response, 2) allow for regular training in in-situ settings, and 3) enable data-rich performance-focused peer debriefing. In our predicate SBIR Phase I proposal, XiMiO Health, Inc. proposed developing the first smartwatch-enabled Basic Life Support (BLS) application for use in both training and clinical response - a system we call Relay Response. Our first specific aim was to design a BLS App with real-time decision support to American Heart Association (AHA) protocols and real-time CPR depth and rate performance feedback. To accomplish this, we proposed developing an app with an intuitive user interface capable of displaying real-time depth and rate feedback from a novel algorithm that calculates depth and rate from accelerometer sensor data. Additionally, we proposed developing a cloud-based database linked to our BLS App to enable real-time data sharing between rescuers responding to a cardiac arrest. Shortly, we will begin benchtop testing to demonstrate proof-of-concept that our BLS App performs as intended. Our second specific aim was to test the feasibility of our BLS App in a CPR simulation study. The study will include 30 participants with a wide range of CPR experience (in-hospital providers, EMTs, and noncertified personnel), using CPR manikins to establish proof-of- concept validation of the BLS App’s performance and utility as a CPR aid. Our study is on schedule and will commence in Q1 2022. With the I-Corps program, the Team’s objective is to validate and characterize our beachhead market for the BLS App – inclusive of developing buying personas, value propositions, pricing models, and sales processes. We expect our success in characterizing our beachhead market during the I-Corps program will allow us to establish early commercial customers and sales channel partnerships. Additionally, the commercial traction that will result from us successfully completing the I-Corps program will reduce the commercial risk to institutional investors and will accelerate our ability to attract venture capital. Ultimately, we believe our success will provide strong support to our SBIR Phase II application, which we anticipate submitting in Q2 2022.