Mechanisms of pediatric overweight and obesity underlying susceptibility to multisystem inflammatory syndrome in children (MIS-C)

儿童超重和肥胖易患儿童多系统炎症综合征的机制（MIS-C）

• 批准号: 10544668
• 负责人: Janet Chou
• 金额: $ 10.22万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544668
• 关键词: 12 year old; 2019-nCoV; Accounting; Acute; Adult; Antiviral Response; Applications Grants; Autoimmune Diseases; Bachelor' s Degree; Biological; Biological Markers; Blood Coagulation Disorders; Body mass index; Body measure procedure; COVID-19; COVID-19 detection; COVID-19 pandemic; COVID-19 vaccine; Cells; Child; Childhood; Clinic; Clinical Immunology; Collaborations; Communicable Diseases; Complication; Coronary Aneurysm; Critical Care; Data; Data Analyses; Data Set; Development; Development Plans; Diagnosis; Disease; Doctor of Philosophy; Endocrinology; Ensure; Environment; Europe; Exanthema; Exhibits; Fever; First Generation College Students; Flow Cytometry; Functional disorder; Gene Expression Profile; Genetic Polymorphism; Genetic Screening; Genetic study; Goals; HIV; Health Disparities Research; Hematological Disease; Human; Immune; Immune response; Immunity; Immunologics; Immunology; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Infrastructure; Interferons; Intestines; Investigation; Laboratories; Leadership; Learning; Link; Lung Transplantation; Lymphopenia; Macaca mulatta; Manuscripts; Master' s Degree; Measurement; Measures; Mediating; Medicine; Mentors; Mentorship; Metabolism; Methods; Molecular; Mothers; Multiomic Data; Multisystem Inflammatory Syndrome in Children; Myocardial dysfunction; NF-kappa B; Obesity; Only Child; Outcome; Overweight; Paper; Pathology; Patients; Pennsylvania; Peripheral Blood Mononuclear Cell; Phase; Physicians; Plasma; Population; Predisposition; Prevalence; Proteome; Publishing; Pulmonary Heart Disease; Research; Research Personnel; Research Support; Research Training; Risk; Risk Factors; SARS-CoV-2 infection; Sampling; Scientist; Severities; Shock; Signal Pathway; Signal Transduction; Societies; Sociology; Stimulus; Students; Symptoms; Syndrome; T-Cell Activation; T-Lymphocyte; Talents; Techniques; Testing; Time; Toll-like receptors; Training; Transcriptional Activation; Transplant Recipients; United States; Universities; Vaccine Clinical Trial; Variant; Viral; Virus; Virus Diseases; Weight; Weight maintenance regimen; Work; acute infection; base; career; career development; cohort; comorbidity; cytokine; cytopenia; data integration; design; disorder risk; experience; experimental study; gastrointestinal symptom; genetic epidemiology; genetic risk factor; genetic variant; idiopathic pulmonary fibrosis; immune activation; insight; meetings; microbial community; obese patients; obesity in children; overweight child; parent grant; pathogen; primary caregiver; programs; response; severe COVID-19; skills; transcriptome sequencing; vaccine candidate

PROJECT SUMMARY The proposed studies for this diversity supplement will provide career development and in-depth training in translational immunology for a talented candidate with a Master’s degree in Cellular and Molecular Pathobiology. The parent grant for this application investigates the mechanisms by which pediatric overweight and obesity increase the risk of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe pediatric complication of SARS-CoV-2 infection. In leading the proposed studies, the candidate will develop expertise in concepts of inflammatory signaling and in widely applicable methods used to measure human immune cell activation. From this work, we anticipate that the candidate will publish at least one first-author paper and a present at the national Clinical Immunology Society meeting in 2023. Mentorship from two successful physician-scientist investigators, combined with collaborative interactions with the parent grant study team, will provide highly relevant career development opportunities towards the candidate’s goal of obtaining an MD/PhD at the interface of immunity and infectious pathogens.

项目摘要 拟议的多样性补充研究将提供职业发展和深入培训， 翻译免疫学为一个有才华的候选人在细胞和分子病理学硕士学位。 这项申请的家长补助金调查了儿童超重和肥胖的机制， 增加儿童多系统炎症综合征（MIS-C）的风险，这是一种严重的儿科并发症 SARS-CoV-2感染。在领导拟议的研究中，候选人将发展以下概念的专业知识： 炎症信号传导和用于测量人免疫细胞活化的广泛适用的方法。从 这项工作，我们预计候选人将发表至少一篇第一作者论文，并在国家 2023年临床免疫学会会议。两位成功的医学科学家研究者的指导， 结合与家长补助金研究团队的合作互动，将提供高度相关的职业生涯 发展机会，以实现候选人在免疫界面获得MD/PhD的目标 和传染性病原体。