Mechanisms of pediatric overweight and obesity underlying susceptibility to multisystem inflammatory syndrome in children (MIS-C)

儿童超重和肥胖易患儿童多系统炎症综合征的机制（MIS-C）

基本信息

批准号：
10544668
负责人：
Janet Chou
金额：
$ 10.22万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10544668
关键词：
12 year old 2019-nCoV Accounting Acute Adult Antiviral Response Applications Grants Autoimmune Diseases Bachelor&apos s Degree Biological Biological Markers Blood Coagulation Disorders Body mass index Body measure procedure COVID-19 COVID-19 detection COVID-19 pandemic COVID-19 vaccine Cells Child Childhood Clinic Clinical Immunology Collaborations Communicable Diseases Complication Coronary Aneurysm Critical Care Data Data Analyses Data Set Development Development Plans Diagnosis Disease Doctor of Philosophy Endocrinology Ensure Environment Europe Exanthema Exhibits Fever First Generation College Students Flow Cytometry Functional disorder Gene Expression Profile Genetic Polymorphism Genetic Screening Genetic study Goals HIV Health Disparities Research Hematological Disease Human Immune Immune response Immunity Immunologics Immunology Individual Infection Inflammation Inflammatory Inflammatory Response Infrastructure Interferons Intestines Investigation Laboratories Leadership Learning Link Lung Transplantation Lymphopenia Macaca mulatta Manuscripts Master&apos s Degree Measurement Measures Mediating Medicine Mentors Mentorship Metabolism Methods Molecular Mothers Multiomic Data Multisystem Inflammatory Syndrome in Children Myocardial dysfunction NF-kappa B Obesity Only Child Outcome Overweight Paper Pathology Patients Pennsylvania Peripheral Blood Mononuclear Cell Phase Physicians Plasma Population Predisposition Prevalence Proteome Publishing Pulmonary Heart Disease Research Research Personnel Research Support Research Training Risk Risk Factors SARS-CoV-2 infection Sampling Scientist Severities Shock Signal Pathway Signal Transduction Societies Sociology Stimulus Students Symptoms Syndrome T-Cell Activation T-Lymphocyte Talents Techniques Testing Time Toll-like receptors Training Transcriptional Activation Transplant Recipients United States Universities Vaccine Clinical Trial Variant Viral Virus Virus Diseases Weight Weight maintenance regimen Work acute infection base career career development cohort comorbidity cytokine cytopenia data integration design disorder risk experience experimental study gastrointestinal symptom genetic epidemiology genetic risk factor genetic variant idiopathic pulmonary fibrosis immune activation insight meetings microbial community obese patients obesity in children overweight child parent grant pathogen primary caregiver programs response severe COVID-19 skills transcriptome sequencing vaccine candidate

项目摘要

PROJECT SUMMARY The proposed studies for this diversity supplement will provide career development and in-depth training in translational immunology for a talented candidate with a Master’s degree in Cellular and Molecular Pathobiology. The parent grant for this application investigates the mechanisms by which pediatric overweight and obesity increase the risk of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe pediatric complication of SARS-CoV-2 infection. In leading the proposed studies, the candidate will develop expertise in concepts of inflammatory signaling and in widely applicable methods used to measure human immune cell activation. From this work, we anticipate that the candidate will publish at least one first-author paper and a present at the national Clinical Immunology Society meeting in 2023. Mentorship from two successful physician-scientist investigators, combined with collaborative interactions with the parent grant study team, will provide highly relevant career development opportunities towards the candidate’s goal of obtaining an MD/PhD at the interface of immunity and infectious pathogens.

项目摘要对这种多样性补充的拟议研究将提供职业发展和深入的培训具有细胞和分子病理生物学硕士学位的才华横溢的候选人的转化免疫学。该申请的父母赠款调查了小儿增持和肥胖的机制增加儿童多系统炎症综合征的风险（MIS-C），严重的小儿并发症 SARS-COV-2感染。在领导拟议的研究时，候选人将在概念上发展专业知识炎症信号传导以及用于测量人类免疫细胞激活的广泛的适用方法。从这项工作，我们预计候选人将在国家 2023年临床免疫学会会议。来自两个成功的身体科学研究者的指导，结合与父母赠款研究团队的协作互动，将提供高度相关的职业候选人在免疫接口获得MD/博士学位的目标的发展机会和感染性病原体。