Molecular Basis of Allergic and Immunologic Disease

过敏和免疫疾病的分子基础

• 批准号: 10609496
• 负责人: Janet Chou
• 金额: $ 75.62万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609496
• 关键词: Allergic Disease; Immune System Diseases; Molecular

The prevalence of pediatric allergic, immunological and rheumatologic disorders has been steadily increasing with more than 15% of children now affected. However, the number of physicians trained to treat children with these conditions as well as to investigate the genetics, pathogenesis and innovative approaches to therapy of these disorders remains disproportionately small. In addition, the role of the immune response in modulating the clinical course of infectious disease is coming into sharp focus with the COVID-19 pandemic. There is a great need both to advance understanding of the basic immunobiology underlying these conditions and to generate a highly qualified workforce of investigators who will do this work. Recent advances in understanding of the immune system, along with the emergence of powerful yet complex research technologies in molecular biology, transcriptomics, metabolomics, human genetics, epigenetics, structural biology, cell biology and immunology have not only created fertile ground for advancement of understanding of immunological mechanisms but have made it essential for trainees to develop understanding of and experience in these approaches. Such training will prepare MD and PhD scientists to advance our knowledge through basic research, clinical investigation and the implementation of novel therapeutic strategies. Equally important, it will generate a cadre of physician scientists ready to train the next generation of investigators. The proposed training program will recruit a diverse group of the most talented and committed young pediatric physician scientists as well as PhD’s (all postdoctoral) committed to clinically relevant immunology research and will provide them with an intensive training experience in research in an unparalleled environment. In the year prior to enrollment in the program, physicians will receive one year of clinical training (not funded by this grant). All training will be within the general discipline of Immunology, with a broad representation of immunological disorders (including asthma, food allergy, atopic dermatitis, primary immune deficiency syndromes, systemic lupus erythematosus, Kawasaki disease) and basic immunological mechanisms (such as tolerance, immunogenomics, epigenetics, innate immunity, cellular immunology and immune responses to SARS-CoV-2) covered by an internationally recognized faculty in the Harvard Medical School community. A three-year training experience is proposed for 9 trainees per year, each with MD, MD-PhD or PhD credentials.

小儿过敏性，免疫学和风湿病的患病率一直在稳步增加 现在有超过15％的儿童受到影响。但是，接受过治疗儿童的医师人数 这些条件以及研究遗传学，发病机理和创新方法 这些疾病的不成比例很小。另外，免疫反应在调节中的作用 传染病的临床过程随着19号大流行而引起人们的焦点。有一个 非常需要促进对这些条件基本的基本免疫生物学的理解以及 生产一支高素质的调查员劳动力，他们将完成这项工作。理解的最新进展 免疫系统的出现，分子中强大而复杂的研究技术的出现 生物学，转录组学，代谢组学，人遗传学，表观遗传学，结构生物学，细胞生物学和 免疫学不仅为了解免疫学的理解创造了肥沃的基础 机制，但使培训在这些方面发展和经验至关重要 方法。这样的培训将使MD和博士学位科学家通过基本来促进我们的知识 研究，临床研究和新型治疗策略的实施。同样重要的是 生成一群物理科学家，准备培训下一代研究人员。提议 培训计划将招募一个最有才华和忠诚的年轻儿科医生的潜水员小组 科学家以及博士（所有博士后）致力于临床相关的免疫学研究，并将 在无与伦比的环境中为他们提供有关研究的密集培训经验。前一年 为了入学该计划，医生将接受一年的临床培训（未由这笔赠款资助）。全部 培训将在免疫学的一般学科中，并具有广泛的免疫学代表 疾病（包括哮喘，食物过敏，特应性皮炎，原发性免疫缺陷综合症，全身性 红斑狼疮，川崎病）和基本的免疫机制（例如耐受性， 免疫基因组学，表观遗传学，先天性免疫学，细胞免疫学和免疫回报对SARS-COV-2） 由哈佛医学院社区的国际公认的教师覆盖。三年 培训经验每年提供9名学员，每个学员都有MD，MD-PHD或PHD证书。

项目成果

Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site.

• DOI: 10.1016/j.jaci.2016.09.057
• 发表时间: 2017-07
• 期刊: The Journal of allergy and clinical immunology
• 作者: Platt CD;Massaad MJ;Cangemi B;Schmidt B;Aldhekri H;Geha RS
• 通讯作者: Geha RS

Season of birth and food-induced anaphylaxis in Boston.

• DOI: 10.1111/j.1398-9995.2010.02384.x
• 发表时间: 2010-11
• 期刊: Allergy
• 影响因子: 12.4
• 作者: Vassallo MF;Banerji A;Rudders SA;Clark S;Camargo CA Jr
• 通讯作者: Camargo CA Jr

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling.

• DOI: 10.1016/j.jaci.2010.11.009
• 发表时间: 2011-03
• 期刊: The Journal of allergy and clinical immunology
• 作者: Mathias CB;Hobson SA;Garcia-Lloret M;Lawson G;Poddighe D;Freyschmidt EJ;Xing W;Gurish MF;Chatila TA;Oettgen HC
• 通讯作者: Oettgen HC

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

• DOI: 10.1016/j.molcel.2020.09.029
• 发表时间: 2020-11-05
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Wang L;Wu D;Robinson CV;Wu H;Fu TM
• 通讯作者: Fu TM

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.

核小体重塑剂 Mi-2β 的染色质限制以及与谱系特异性转录调节因子的功能相互作用控制 B 细胞分化。

• DOI: 10.1101/gad.321901.118
• 发表时间: 2019
• 期刊: Genes & development
• 影响因子: 10.5
• 作者: Yoshida,Toshimi;Hu,Yeguang;Zhang,Zhihong;Emmanuel,AkinolaO;Galani,Kiriaki;Muhire,Brejnev;Snippert,HugoJ;Williams,ChristineJ;Tolstorukov,MichaelY;Gounari,Fotini;Georgopoulos,Katia
• 通讯作者: Georgopoulos,Katia