权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Molecular Basis of Allergic and Immunologic Disease

过敏和免疫疾病的分子基础

基本信息

批准号：
10609496
负责人：
Janet Chou
金额：
$ 75.62万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-08-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10609496
关键词：
Allergic Disease Immune System Diseases Molecular

项目摘要

The prevalence of pediatric allergic, immunological and rheumatologic disorders has been steadily increasing with more than 15% of children now affected. However, the number of physicians trained to treat children with these conditions as well as to investigate the genetics, pathogenesis and innovative approaches to therapy of these disorders remains disproportionately small. In addition, the role of the immune response in modulating the clinical course of infectious disease is coming into sharp focus with the COVID-19 pandemic. There is a great need both to advance understanding of the basic immunobiology underlying these conditions and to generate a highly qualified workforce of investigators who will do this work. Recent advances in understanding of the immune system, along with the emergence of powerful yet complex research technologies in molecular biology, transcriptomics, metabolomics, human genetics, epigenetics, structural biology, cell biology and immunology have not only created fertile ground for advancement of understanding of immunological mechanisms but have made it essential for trainees to develop understanding of and experience in these approaches. Such training will prepare MD and PhD scientists to advance our knowledge through basic research, clinical investigation and the implementation of novel therapeutic strategies. Equally important, it will generate a cadre of physician scientists ready to train the next generation of investigators. The proposed training program will recruit a diverse group of the most talented and committed young pediatric physician scientists as well as PhD’s (all postdoctoral) committed to clinically relevant immunology research and will provide them with an intensive training experience in research in an unparalleled environment. In the year prior to enrollment in the program, physicians will receive one year of clinical training (not funded by this grant). All training will be within the general discipline of Immunology, with a broad representation of immunological disorders (including asthma, food allergy, atopic dermatitis, primary immune deficiency syndromes, systemic lupus erythematosus, Kawasaki disease) and basic immunological mechanisms (such as tolerance, immunogenomics, epigenetics, innate immunity, cellular immunology and immune responses to SARS-CoV-2) covered by an internationally recognized faculty in the Harvard Medical School community. A three-year training experience is proposed for 9 trainees per year, each with MD, MD-PhD or PhD credentials.

儿童过敏性、免疫性和风湿性疾病的患病率一直在稳步上升超过15%的儿童受到影响。然而，接受过治疗儿童的医生人数这些条件，以及研究遗传学，发病机制和创新的治疗方法，这些疾病仍然不成比例地小。此外，免疫应答在调节随着COVID-19大流行，传染病的临床过程成为焦点。有一个因此，迫切需要提高对这些疾病背后的基本免疫生物学的理解，培养一支高素质的调查人员队伍来从事这项工作。认识的最新进展沿着强大而复杂的分子生物学研究技术的出现，生物学、转录组学、代谢组学、人类遗传学、表观遗传学、结构生物学、细胞生物学和免疫学不仅为促进对免疫学理解创造了肥沃的土壤，机制，但必须让受训者了解和体验这些机制，接近。这样的培训将使MD和PhD科学家做好准备，通过基本的研究、临床调查和实施新的治疗策略。同样重要的是，培养一支科学家队伍，准备培养下一代研究人员。拟议培训计划将招募一批最有才华和最忠诚的年轻儿科医生科学家以及博士（所有博士后）致力于临床相关的免疫学研究，并将为他们提供在无与伦比的环境中进行研究的强化培训经验。前一年参加该计划的医生将接受一年的临床培训（不受该补助金的资助）。所有培训将在免疫学的一般学科范围内进行，具有广泛的免疫学代表性疾病（包括哮喘、食物过敏、特应性皮炎、原发性免疫缺陷综合征、全身性红斑狼疮，川崎病）和基本的免疫机制（例如耐受性，免疫基因组学、表观遗传学、先天免疫、细胞免疫学和对SARS-CoV-2的免疫应答）由哈佛医学院社区的国际公认的教师所覆盖。三年每年培训9名学员，每个人都有MD，MD-PhD或PhD证书。

项目成果

期刊论文数量（174）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

完整的人类V-ATPase的结构揭示了其组装的机制。

DOI：
10.1016/j.molcel.2020.09.029
发表时间：
2020-11-05
期刊：
Molecular cell
影响因子：
16
作者：
Wang L;Wu D;Robinson CV;Wu H;Fu TM
通讯作者：
Fu TM

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling.

DOI：
10.1016/j.jaci.2010.11.009
发表时间：
2011-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
0
作者：
Mathias CB;Hobson SA;Garcia-Lloret M;Lawson G;Poddighe D;Freyschmidt EJ;Xing W;Gurish MF;Chatila TA;Oettgen HC
通讯作者：
Oettgen HC

Season of birth and food-induced anaphylaxis in Boston.

DOI：
10.1111/j.1398-9995.2010.02384.x
发表时间：
2010-11
期刊：
Allergy
影响因子：
12.4
作者：
Vassallo MF;Banerji A;Rudders SA;Clark S;Camargo CA Jr
通讯作者：
Camargo CA Jr

Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.

DOI：
10.1053/j.gastro.2011.11.031
发表时间：
2012-03
期刊：
Gastroenterology
影响因子：
29.4
作者：
Liao G;Detre C;Berger SB;Engel P;de Waal Malefyt R;Herzog RW;Bhan AK;Terhorst C
通讯作者：
Terhorst C

Higher incidence of pediatric anaphylaxis in northern areas of the United States.

美国北部地区儿童过敏反应的发生率较高。