Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias (ADRD)

摘要 拟于2023-2024年举办一系列虚拟/面对面混合讲习班的下两期讲习班。 这两个会议的目的是提供有关现有和最近开发的分析方法的新知识 方法可以用于详细、可靠和可重复性的分析，以在理解 阿尔茨海默病(AD)、相关痴呆症(ADRD)健康相关差异的原因和机制 以及其他与年龄相关的突出疾病。该系列的长期目标是提供专注于以下内容的资源 传播方法知识，展示新开发的方法的能力， 扩大老法运用的严密性和广泛性，促进大健康的正确运用 从方法论和伦理的角度提供数据，并为专家和新手提供论坛 对健康差距和与年龄相关的疾病感兴趣，讨论他们的想法并展示他们的研究。在……里面 在规划2023-2024年讲习班期间，我们将继续开展已经完成的重要工作 我们的团队，并在本系列之前的研讨会和研讨会的基础上再接再厉，包括 由本提案(R13AG069381)的父母拨款资助的项目。这已经成为课程中的惯例 在该系列中，2023/2024年讲习班的确切时间表将在收到以下方面的意见后最后敲定 2022/2023年参与者。我们在使用这一模式方面取得了巨大的成功，这一点从以下几个项目的积极参与中可见一斑 阿尔茨海默病研究中心、少数族裔机构和其他方法重点的代表 小组会议以及我们的研讨会和研讨会的出席人数不断增加。研讨会的总体重点 将是：2023年《评估AD/ADRD风险和结果的异质性和结构》和《决定因素 2024年AD/ADRD风险评估：将创新方法应用于大数据“。每个研讨会都将 包括三次实质性会议和一次辅助方法会议。实质性会议清单将包括： 一)混合型痴呆症及其组成部分，二)AD/ADRD存活率的趋势和差异，三) 新冠肺炎大流行与AD/ADRD风险和结局，IV)年轻人在AD和相关风险中的作用 差异，五)多病/共病和阿尔茨海默病风险，以及六)与临床无关的风险决定因素 AD/ADRD及其在时间趋势和健康差距中的作用。方法论会议将讨论支持性 将处理多个现代管理、人口和临床数据集的方法。我们计划 通过将方法学创新与 在讲解听众最感兴趣的话题的同时进行实际动手演示 在过去的讲习班过程中，通过联合调查和会后调查收集的反馈。 此外，通过以统一的形式将研究人员聚集在一起，而不是将他们分散在不同的领域- 我们努力克服这类研究涉及的领域的零散性质的具体部分 它以方法和数据的应用为中心，使其对早期职业调查人员特别有用。

Abstract The next two installments of a series of hybrid virtual/in-person workshops to be held in 2023-2024 are proposed. The aim of these two sessions is to provide new knowledge on how existing and recently developed analytic methods can be used for detailed, reliable, and reproducible analysis to make progress in understanding the causes and mechanisms of health-related disparities in Alzheimer’s disease (AD), related dementias (ADRD), and other prominent age-related diseases. The long-term goal of the series is to provide a resource focused on diffusing methodological know-how, demonstrating the capabilities of newly developed methodologies, expanding on the rigor and range of application of well-established methods, promoting correct use of big health data both from a methodological and ethical prospective as well as providing a forum for experts and newcomers interested in health disparities and age-related diseases to discuss their ideas and showcase their research. In the planning of the 2023-2024 workshops, we will continue the important work that has already been done by our team and build upon the accomplishments of previous Symposia and Workshops in this series including those funded by the parent grant of this proposal (R13AG069381). As has become customary over the course of the series the exact schedules of the 2023/2024 workshops will be finalized after receiving input from 2022/2023 participants. We have had great success in using this model as evidenced by active participation of representatives of Alzheimer's Disease research centers, minority institutions, and other methodological focus groups as well as the increasing attendance of our workshops and symposia. The overall focus of the workshops will be: “Evaluating heterogeneity and Structure in AD/ADRD risks and outcomes” for 2023 and “Determinants of AD/ADRD risks: application of innovative methodologies to Big Health Data” for 2024. Each workshop will contain three substantive and one supporting methodologic session. The list of substantive sessions will include: i) patterns of mixed dementia and their components, ii) trends and disparities in AD/ADRD survival, iii) the COVID-19 pandemic and AD/ADRD risk and outcomes, iv) role of younger ages in the risk of AD and associated disparities, v) multimorbidity/comorbidity and AD risk, and vi) non-clinic-related determinants of the risk of AD/ADRD and their role in time trends and health disparities. The methodologic session will discuss supportive approaches that will deal with multiple modern administrative, population, and clinical datasets. We plan to maintain the accessibility level of the methodologic presentations by combining methodological innovations with practical hands-on demonstrations while addressing topics of the highest interest to the audience based on feedback gathered using pool and post-event surveys administered over the course of past Workshops. Furthermore, by bringing researchers together in a unified format rather than separating them across field- specific sections we endeavor to overcome the fragmented nature of the fields involved in such research by centering it around the application of methods and data, making it especially useful for early career investigators.