SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.

摘要(总体) 圣安东尼奥在医学真菌学领域有着丰富的卓越传统，包括 球孢子菌病，又称谷热。这些感染影响了数十万人 美国西南部干旱地区流行地区的健康和免疫功能低下的人，患有 大多数病例发生在加利福尼亚州和亚利桑那州。治疗这些感染的药物很少，而且没有 现已有疫苗可用。抗生素耐药性的不断增长是一个主要问题，关于 感染地域的扩大非常令人担忧。为了解决这些主要缺点， 我们建议建立圣安东尼奥球孢子菌病合作研究中心 中心(SA-CCRC)。新的中心将是一个高度协作的地方，提供协同的多和 中心成员的跨学科互动，其中包括在 球虫研究领域，以及具有丰富知识和/或技术专长的其他领域 在其他领域，他们的人才第一次被吸引到这个领域。总体而言，SA-CCRC 创建最佳聚合基础设施以支持集成研究，利用每个 参与的网站和组织，并延伸到建立新的学术- 产业伙伴关系。我们的中心非常注重翻译，特别专注于 球孢子菌病的抗真菌药物和疫苗的开发。中心由一个 行政核心，将作为中央枢纽，提供必要的组织、行政 以及该中心日常运作的财务监督结构。SA的总体目标是- CCRC是：i)通过以下途径促进球孢子菌病领域的基础、翻译和临床研究 调查员主导的研究项目，ii)使最先进的技术适应、开发和实施 球孢子菌病研究领域支持三个不同的项目和球孢子菌病 整个社区，以及iii)管理一个开发和研究方案，以获得试点资金和 指导初级研究人员和球孢子菌病领域的新手。总而言之，建议的 SA-CCRC计划将填补关键空白，并将在以下领域产生强大和可持续的影响 球孢子菌病研究。

Summary (Overall) San Antonio has a rich tradition of excellence in the field of Medical Mycology, including Coccidioidomycosis, also referred to as Valley Fever. These infections affect hundreds of thousands of healthy and immunocompromised individuals in the endemic areas of the arid Southwest U.S., with a majority of cases in California and Arizona. There are very few drugs to treat these infections and no vaccine is available. Growing levels of antibiotic resistance are a major concern, and the latest data on the expansion of the geographical area of infection is very worrisome. To address these major shortcomings, we propose the establishment of the San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC). The new Center will be a highly collaborative place for synergistic multi- and interdisciplinary interactions by members of the Center, which include highly experienced investigators in the field of Coccidioides research, as well as others with substantial knowledge and/or technical expertise in other areas whose talents are being attracted to this field for the very first time. Overall, the SA-CCRC creates an optimal cohesive infrastructure to support integrated research, leverages resources at each of the participating sites and organizations, and also extends to the establishment of novel academic- industrial partnerships. Our Center has a strong translational emphasis, being distinctively focused on the development of antifungal drugs and vaccines against coccidioidomycosis. The center is anchored by an administrative core which will serve a central hub for providing the necessary organizational, administrative and financial oversight structure for the Center’s day-to-day operations. The overall objectives for the SA- CCRC are: i) to advance basic, translational and clinical research in the field of Coccidioidomycosis via investigator-driven research projects, ii) to adapt, develop and implement state of the art techniques to the Coccidioidomycosis field of research in support of the three different projects and the coccidioidomycosis community at large, and iii) to administer a Development and Research Program for pilot funding and mentoring of junior investigators and those new to the field of coccidioidomycosis. Altogether, the proposed SA-CCRC program will fill critical voids and will have a powerful and sustainable effect on the field of coccidioidomycosis research.