SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.

总结（总体） 圣安东尼奥在医学真菌学领域有着丰富的优秀传统，包括 球孢子菌病，也被称为山谷热。这些感染影响了数十万人， 在美国西南部干旱的地方病流行区的健康和免疫功能低下的个体，与 大多数病例发生在加州和亚利桑那州。治疗这些感染的药物很少， 疫苗是可用的。越来越多的抗生素耐药性是一个主要问题，最新的数据显示， 感染地域的扩大非常令人担忧。为了克服这些主要缺点， 我们建议建立基于圣安东尼奥的球孢子菌病合作研究 中心（SA-CCRC）。新中心将是一个高度协作的地方， 中心成员的跨学科互动，其中包括经验丰富的研究人员， 球孢子菌研究领域，以及其他具有丰富知识和/或技术专长的人 其他领域的人才首次被吸引到这个领域。总的来说，SA-CCRC 创建一个最佳的凝聚力基础设施，以支持综合研究，利用资源，在每一个 参与的网站和组织，并还延伸到建立新颖的学术- 工业伙伴关系。我们的中心有一个强大的翻译重点，特别是专注于 开发抗球孢子菌病的抗真菌药物和疫苗。中心由一个 行政核心，将作为一个中心枢纽，提供必要的组织、行政、 中心日常运作的财务监督结构。SA的总体目标- CCRC是：i）通过以下途径推进球孢子菌病领域的基础，转化和临床研究 研究人员推动的研究项目，ii）适应，开发和实施最先进的技术， 球孢子菌病研究领域的支持三个不同的项目和球孢子菌病 （三）管理试点资金的发展和研究计划， 指导初级研究者和球孢子菌病领域的新手。总的来说， SA-CCRC计划将填补关键的空白，并将对该领域产生强大而可持续的影响。 球孢子菌病研究。

Summary (Overall) San Antonio has a rich tradition of excellence in the field of Medical Mycology, including Coccidioidomycosis, also referred to as Valley Fever. These infections affect hundreds of thousands of healthy and immunocompromised individuals in the endemic areas of the arid Southwest U.S., with a majority of cases in California and Arizona. There are very few drugs to treat these infections and no vaccine is available. Growing levels of antibiotic resistance are a major concern, and the latest data on the expansion of the geographical area of infection is very worrisome. To address these major shortcomings, we propose the establishment of the San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC). The new Center will be a highly collaborative place for synergistic multi- and interdisciplinary interactions by members of the Center, which include highly experienced investigators in the field of Coccidioides research, as well as others with substantial knowledge and/or technical expertise in other areas whose talents are being attracted to this field for the very first time. Overall, the SA-CCRC creates an optimal cohesive infrastructure to support integrated research, leverages resources at each of the participating sites and organizations, and also extends to the establishment of novel academic- industrial partnerships. Our Center has a strong translational emphasis, being distinctively focused on the development of antifungal drugs and vaccines against coccidioidomycosis. The center is anchored by an administrative core which will serve a central hub for providing the necessary organizational, administrative and financial oversight structure for the Center’s day-to-day operations. The overall objectives for the SA- CCRC are: i) to advance basic, translational and clinical research in the field of Coccidioidomycosis via investigator-driven research projects, ii) to adapt, develop and implement state of the art techniques to the Coccidioidomycosis field of research in support of the three different projects and the coccidioidomycosis community at large, and iii) to administer a Development and Research Program for pilot funding and mentoring of junior investigators and those new to the field of coccidioidomycosis. Altogether, the proposed SA-CCRC program will fill critical voids and will have a powerful and sustainable effect on the field of coccidioidomycosis research.