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SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.

SA-CCRC-球孢子菌病治疗方法和疫苗的开发。

基本信息

批准号：
10541225
负责人：
CHIUNG-YU HUNG
金额：
$ 135.7万
依托单位：
UNIVERSITY OF TEXAS SAN ANTONIO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10541225
关键词：
Address Affect Antibiotic Resistance Antifungal Agents Area Arizona Azole resistance Basic Science Bioinformatics California Cells Clinical Clinical Research Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Communities Data Development Disease Outcome Drug Screening Ensure Evaluation Funding Genomics Geographic Locations Goals Health Health Care Costs Immunity Immunocompromised Host Immunotherapeutic agent Immunotherapy In Vitro Individual Infection Infrastructure Institution Investigator-Initiated Research Knowledge Libraries Lung Medical Mentors Messenger RNA Modeling Morbidity - disease rate Mycoses Office of Administrative Management Persons Pharmaceutical Preparations Predisposition Prevention Research Research Personnel Research Project Grants Resources Risk Scientist Site Southwestern United States Structure Talents Technical Expertise Techniques Technology Testing The science of Mycology Therapeutic Time Training Translational Research Treatment outcome United States Vaccines career development clinically significant desert fever design drug development experience high throughput screening improved in vivo industry partner instrumentation member new technology next generation novel operation programs research and development therapeutic development translational pipeline vector-based vaccine

项目摘要

Summary (Overall) San Antonio has a rich tradition of excellence in the field of Medical Mycology, including Coccidioidomycosis, also referred to as Valley Fever. These infections affect hundreds of thousands of healthy and immunocompromised individuals in the endemic areas of the arid Southwest U.S., with a majority of cases in California and Arizona. There are very few drugs to treat these infections and no vaccine is available. Growing levels of antibiotic resistance are a major concern, and the latest data on the expansion of the geographical area of infection is very worrisome. To address these major shortcomings, we propose the establishment of the San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC). The new Center will be a highly collaborative place for synergistic multi- and interdisciplinary interactions by members of the Center, which include highly experienced investigators in the field of Coccidioides research, as well as others with substantial knowledge and/or technical expertise in other areas whose talents are being attracted to this field for the very first time. Overall, the SA-CCRC creates an optimal cohesive infrastructure to support integrated research, leverages resources at each of the participating sites and organizations, and also extends to the establishment of novel academic- industrial partnerships. Our Center has a strong translational emphasis, being distinctively focused on the development of antifungal drugs and vaccines against coccidioidomycosis. The center is anchored by an administrative core which will serve a central hub for providing the necessary organizational, administrative and financial oversight structure for the Center’s day-to-day operations. The overall objectives for the SA- CCRC are: i) to advance basic, translational and clinical research in the field of Coccidioidomycosis via investigator-driven research projects, ii) to adapt, develop and implement state of the art techniques to the Coccidioidomycosis field of research in support of the three different projects and the coccidioidomycosis community at large, and iii) to administer a Development and Research Program for pilot funding and mentoring of junior investigators and those new to the field of coccidioidomycosis. Altogether, the proposed SA-CCRC program will fill critical voids and will have a powerful and sustainable effect on the field of coccidioidomycosis research.

总结(整体)