Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
基本信息
- 批准号:10542334
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2023-08-27
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBAK1 geneCell Surface ReceptorsCell membraneCell surfaceCellsComplexCytoplasmEukaryotaEventFeedbackGene ExpressionGoalsGrowthHomeostasisImmuneImmune responseImmune signalingImmunityInfectionInterdisciplinary StudyLigandsMediatingMicrobeModificationMolecularNatural ImmunityPathway interactionsPatternPattern recognition receptorPeptidesPerceptionPhosphorylationPhosphotransferasesPlantsPost-Translational Protein ProcessingPostdoctoral FellowProcessReceptor SignalingReproductionResearchResearch PersonnelResolutionSignal PathwaySignal TransductionSpecificityUbiquitinationattenuationenvironmental adaptationfortificationgraduate studentimmunoregulationmicrobialnovelpathogenreceptorspatiotemporaltraining opportunityundergraduate student
项目摘要
Immune signal perception and integration by cell surface receptors and peptide ligands
Plants and animals rely on pattern-recognition receptors (PRRs) to detect infection by recognizing microbe-
associated molecular patterns (MAMPs). Plant plasma membrane (PM)-resident receptor kinases (RKs) function
as PRRs that sense MAMPs from diverse microbes and collectively contribute to plant immunity. Plant RKs also
perceive a wide range of extrinsic and intrinsic signals and regulate growth, reproduction, and environmental
adaptation. The signaling pathways mediated by many RKs converge at a subfamily of RKs, namely
BAK1/SERKs, that function as shared coreceptors associating with various receptors upon ligand perception
modulating plant immunity, growth, and immune homeostasis. The PM-tethered cytoplasmic kinase BIK1
associates with multiple PRR-BAK1 complexes and relays the intracellular signaling events. Microbial infection
also induces the gene expression of many secreted peptides, which could function as immunomodulatory
phytocytokines perceived by PRRs and fortify plant immunity. This proposal's long-term goal is to elucidate the
mechanisms underlying pathogen signal perception and integration by PRR complexes via shared modules in
coordination with phytocytokines for a rapid, specific, and robust immune response. The proposed research will
address several key questions in the field. The project will elucidate how BIK1-associated PRR receptorsome
dynamics are spatiotemporally regulated and relay the diverse immune signaling. As a critical kinase, BIK1
homeostasis, activities, and subcellular dynamics are regulated by the intertwined phosphorylation and
ubiquitination modifications. The project will define how the shared BAK1/SERK coreceptors maintain the
functional specificity in different receptorsomes. The studies will address how signaling specificity is regulated
with the single-cell resolution at the organismal level. The project will also study how immunomodulatory
phytocytokines coordinate with microbial patterns to mount effective immunity. The proposed interdisciplinary
research will provide ample training opportunities for researchers at different levels, including underrepresented
undergraduate and graduate students and postdoctoral fellows, and will advance our understanding of innate
immunity and signal transduction at the whole organismal level by identifying new components and delineating
novel pathways that regulate immune signal integration, signaling activation, attenuation, and specificity.
细胞表面受体和肽配体的免疫信号感知和整合
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Libo Shan其他文献
Libo Shan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Libo Shan', 18)}}的其他基金
Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
- 批准号:
10797584 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
- 批准号:
10330894 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Immune signal perception and integration by cell surface receptors and peptide liga
细胞表面受体和肽连接体的免疫信号感知和整合
- 批准号:
10890399 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8463568 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune signaling
先天免疫信号中免疫感觉复合物的磷酸化和泛素化
- 批准号:
10065506 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8083239 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8840269 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8291246 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8645647 - 财政年份:2011
- 资助金额:
-- - 项目类别:














{{item.name}}会员




