Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
基本信息
- 批准号:10542334
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2023-08-27
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBAK1 geneCell Surface ReceptorsCell membraneCell surfaceCellsComplexCytoplasmEukaryotaEventFeedbackGene ExpressionGoalsGrowthHomeostasisImmuneImmune responseImmune signalingImmunityInfectionInterdisciplinary StudyLigandsMediatingMicrobeModificationMolecularNatural ImmunityPathway interactionsPatternPattern recognition receptorPeptidesPerceptionPhosphorylationPhosphotransferasesPlantsPost-Translational Protein ProcessingPostdoctoral FellowProcessReceptor SignalingReproductionResearchResearch PersonnelResolutionSignal PathwaySignal TransductionSpecificityUbiquitinationattenuationenvironmental adaptationfortificationgraduate studentimmunoregulationmicrobialnovelpathogenreceptorspatiotemporaltraining opportunityundergraduate student
项目摘要
Immune signal perception and integration by cell surface receptors and peptide ligands
Plants and animals rely on pattern-recognition receptors (PRRs) to detect infection by recognizing microbe-
associated molecular patterns (MAMPs). Plant plasma membrane (PM)-resident receptor kinases (RKs) function
as PRRs that sense MAMPs from diverse microbes and collectively contribute to plant immunity. Plant RKs also
perceive a wide range of extrinsic and intrinsic signals and regulate growth, reproduction, and environmental
adaptation. The signaling pathways mediated by many RKs converge at a subfamily of RKs, namely
BAK1/SERKs, that function as shared coreceptors associating with various receptors upon ligand perception
modulating plant immunity, growth, and immune homeostasis. The PM-tethered cytoplasmic kinase BIK1
associates with multiple PRR-BAK1 complexes and relays the intracellular signaling events. Microbial infection
also induces the gene expression of many secreted peptides, which could function as immunomodulatory
phytocytokines perceived by PRRs and fortify plant immunity. This proposal's long-term goal is to elucidate the
mechanisms underlying pathogen signal perception and integration by PRR complexes via shared modules in
coordination with phytocytokines for a rapid, specific, and robust immune response. The proposed research will
address several key questions in the field. The project will elucidate how BIK1-associated PRR receptorsome
dynamics are spatiotemporally regulated and relay the diverse immune signaling. As a critical kinase, BIK1
homeostasis, activities, and subcellular dynamics are regulated by the intertwined phosphorylation and
ubiquitination modifications. The project will define how the shared BAK1/SERK coreceptors maintain the
functional specificity in different receptorsomes. The studies will address how signaling specificity is regulated
with the single-cell resolution at the organismal level. The project will also study how immunomodulatory
phytocytokines coordinate with microbial patterns to mount effective immunity. The proposed interdisciplinary
research will provide ample training opportunities for researchers at different levels, including underrepresented
undergraduate and graduate students and postdoctoral fellows, and will advance our understanding of innate
immunity and signal transduction at the whole organismal level by identifying new components and delineating
novel pathways that regulate immune signal integration, signaling activation, attenuation, and specificity.
通过细胞表面受体和肽配体的免疫信号感知和整合
植物和动物依靠模式识别受体(PRR)通过识别微生物来检测感染。
相关分子模式(MAMPs)。植物质膜(PM)驻留受体激酶(RKs)功能
作为PRR,其感测来自不同微生物的MAMP并共同有助于植物免疫。工厂RK还
感知广泛的外在和内在信号,并调节生长,繁殖和环境
适应由许多RKs介导的信号传导途径汇聚于RKs的一个亚家族,即
BAK 1/SERKs,在配体感知时作为与各种受体相关的共享共受体发挥作用
调节植物免疫、生长和免疫稳态。PM-tethered cytoplasmic kinase BIK1
与多个PRR-BAK 1复合物结合并传递细胞内信号传导事件。微生物感染
还诱导许多分泌肽的基因表达,这些肽可以作为免疫调节剂发挥作用。
PRR感知的植物细胞因子和强化植物免疫。该提案的长期目标是阐明
病原体信号感知和PRR复合物通过共享模块整合的潜在机制
与植物细胞因子协调,以实现快速、特异性和稳健的免疫应答。拟议的研究将
解决该领域的几个关键问题。该项目将阐明BIK 1相关的PRR受体体
动态是时空调节的,并传递不同的免疫信号。BIK 1作为一种重要的激酶,
内稳态、活动和亚细胞动力学受相互交织的磷酸化和
泛素化修饰该项目将定义共享的BAK 1/SERK共受体如何维持
不同受体体的功能特异性。这些研究将解决信号特异性是如何调节的
具有生物体水平的单细胞分辨率。该项目还将研究免疫调节
植物细胞因子与微生物模式协调以产生有效的免疫力。建议跨学科
研究将为不同级别的研究人员提供充足的培训机会,
本科生,研究生和博士后研究员,并将推进我们对先天
免疫和信号转导在整个生物体水平上通过识别新的成分和描绘
调节免疫信号整合、信号激活、减弱和特异性的新途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Libo Shan', 18)}}的其他基金
Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
- 批准号:
10797584 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Immune signal perception and integration by cell surface receptors and peptide ligands
细胞表面受体和肽配体的免疫信号感知和整合
- 批准号:
10330894 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Immune signal perception and integration by cell surface receptors and peptide liga
细胞表面受体和肽连接体的免疫信号感知和整合
- 批准号:
10890399 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8463568 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune signaling
先天免疫信号中免疫感觉复合物的磷酸化和泛素化
- 批准号:
10065506 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8083239 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8840269 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8291246 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Phosphorylation and ubiquitination of immune sensory complexes in innate immune s
先天免疫中免疫感觉复合物的磷酸化和泛素化
- 批准号:
8645647 - 财政年份:2011
- 资助金额:
-- - 项目类别: