Neural basis of behavioral timescale coordination
Neural basis of behavioral timescale coordination
批准号:
10542829
负责人:
Jan Zimmermann
金额:
$67.47万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-12-15 至 2026-10-31
关键词:
Animal BehaviorAnimalsAnteriorAreaBehaviorBehavioralBrainCharacteristicsCognitionCognitiveCommunicationCouplingDataDecision MakingElectrophysiology (science)EnvironmentEthologyEventExhibitsExperimental DesignsGrainHeadHumanJointsLabelLinkMacacaMacaca mulattaMedialMental disordersMonkeysMotorMovementNeuronsNeurosciencesPatternPhysiologyPopulationPrefrontal CortexPreparationProbabilityProcessProxyReactionReaction TimeRewardsRiskSignal TransductionStructureSystemTechniquesTestingTimeTrainingWorkbehavioral studycingulate cortexcommon symptomdeep learningexpectationexperimental studyflexibilitymachine visionneuralneurobehavioralneurotransmissionnovelstemtoolwireless
中文摘要
行为是在多个空间和时间尺度上组织的,范围从
亚秒运动指令超过多秒的运动计划,以长期觅食模式。
目前还不清楚大脑是如何解决这种多重交织的协调问题的
时间需求。虽然经典的神经科学实验通常会观察或参与
固定的时间尺度或视野,行为学研究长期以来一直专注于分析
自然主义行为跨越自由引发的时间尺度。在这里我们将用小说发展的深
学习姿势估计方法来研究行为和相关的单一单位生理学,
自由活动的恒河猴的觅食行为。首先,我们将建立一个时间表,
猕猴姿势行为编码认知变量,如奖励期望。第二,我们将
在决定中建立神经和行为时间尺度协调之间的联系,
内侧前额叶壁的行动轴,导致前扣带皮层,
记录自由活动的恒河猴的多区域无线电生理。第三、
利用嵌入和连通性分析,我们将揭示区域间和区域内的机制,
时间尺度协调,以了解大脑如何平衡时间尺度的需求。
英文摘要
Behavior is organized across multiple spatial and temporal scales, ranging from
sub-second motor commands over multi-second movement plans to long term foraging patterns.
Currently it is unclear how the brain solves this coordination of multiple intertwined
temporal demands. While classical neuroscience experiments typically look at or engage a
fixed temporal scale or horizon, ethological studies have long focused on the analysis of
naturalistic behavior across freely elicited temporal scales. Here we will use novel developed deep
learning pose estimation approaches to study the behavior and associated single unit physiology of
foraging behavior in freely moving rhesus macaques. First we will establish that timescales of
macaque pose behavior encode cognitive variables such as reward expectation. Second we will
establish the link between neural and behavioral timescale coordinating in the decision to
action axis of the medial prefrontal wall leading to the anterior cingulate cortex by
recording multi-region wireless electrophysiology in freely moving rhesus macaques. Third,
using embedding and connectivity analysis we will uncover the mechanisms for inter and intra areal
timescale coordination to understand how the brain balances temporal scale demands.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Connectome style neuroimaging in non human primates via novel integrated RF platforms
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批准号:10579305
-
项目类别:
-
资助金额:$55.37万
-
财政年份:2022
-
负责人:Jan Zimmermann
-
依托单位:
Connectome style neuroimaging in non human primates via novel integrated RF platforms
-
批准号:10407330
-
项目类别:
-
资助金额:$29.52万
-
财政年份:2022
-
负责人:Jan Zimmermann
-
依托单位:
Connectome style neuroimaging in non human primates via novel integrated RF platforms
-
批准号:10426505
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项目类别:
-
资助金额:$50.21万
-
财政年份:2021
-
负责人:Jan Zimmermann
-
依托单位:
Neural basis of behavioral timescale coordination
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批准号:10332070
-
项目类别:
-
资助金额:$69.05万
-
财政年份:2021
-
负责人:Jan Zimmermann
-
依托单位:
海外基金