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Connectome style neuroimaging in non human primates via novel integrated RF platforms

通过新型集成射频平台对非人类灵长类动物进行连接组型神经成像

基本信息

批准号：
10426505
负责人：
Jan Zimmermann
金额：
$ 50.21万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2022-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10426505
关键词：
Address Anatomy Animal Model Automobile Driving Axon Bone structure Brain Brain region Chronic Communication Custom Databases Development Devices Disease Environment Feedback Foundations Functional Magnetic Resonance Imaging Future Goals Gold Head Health Human Image Implant Investigation Macaca Magnetic Resonance Magnetic Resonance Imaging Maps Measurement Measures Mental disorders Methods Modality Modeling Monkeys Neurons Neurosciences Noise Operative Surgical Procedures Pattern Performance Physiological Positioning Attribute Reproducibility Research Resolution Rest Rodent Signal Transduction Solid Structure System Techniques Testing Thick Time Tracer Translating Translational Research Validation awake bone brain volume cognitive process connectome design exhaustion experimental study high resolution imaging human model in vivo information processing innovation magnetic field miniaturize neuroimaging next generation nonhuman primate novel radio frequency response sample fixation tool translational model ultra high resolution

项目摘要

PROJECT SUMMARY Ultra high field neuroimaging in humans enables unprecedented resolutions that enable, for the first time, the non invasive investigation of directional information processing in vivo. These advances result from the ability of high resolutions to uncover layer specific (feedforward, feedback) activation patterns. These tools however are not validated in translational models that mimic human brain function. The reason for that is primarily due to our current inability to obtain functional magnetic resonance imaging (fMRI) signals at resolutions high enough to resolve layer specific responses in the non human primate. This project aims at developing novel and innovative radiofrequency hardware and using it at the ultra high field strength of 10.5 Tesla to directly test how well whole brain directional connectivity estimates from fMRI correspond with ground truth tract tracing experiments. This development and validation can directly aid us in translating findings from the animal model into future studies of the mesoscopic circuit effects of human mental illness.

项目概要人类超高场神经成像实现了前所未有的分辨率，使首次对体内定向信息处理进行非侵入性研究。这些进步源于高分辨率揭示特定层（前馈，反馈）激活模式。然而，这些工具并未在转化模型中得到验证，模仿人脑功能。其原因主要是由于我们目前无法以足够高的分辨率获取功能磁共振成像 (fMRI) 信号非人类灵长类动物的层特异性反应。该项目旨在开发新颖且创新的射频硬件，并在 10.5 特斯拉的超高场强下使用它直接测试功能磁共振成像的全脑定向连接估计与地面实况追踪实验。这种开发和验证可以直接帮助我们将动物模型的发现转化为未来对介观电路效应的研究人类精神疾病。