Connectome style neuroimaging in non human primates via novel integrated RF platforms
通过新型集成射频平台对非人类灵长类动物进行连接组型神经成像
基本信息
- 批准号:10426505
- 负责人:
- 金额:$ 50.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2022-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAnatomyAnimal ModelAutomobile DrivingAxonBone structureBrainBrain regionChronicCommunicationCustomDatabasesDevelopmentDevicesDiseaseEnvironmentFeedbackFoundationsFunctional Magnetic Resonance ImagingFutureGoalsGoldHeadHealthHumanImageImplantInvestigationMacacaMagnetic ResonanceMagnetic Resonance ImagingMapsMeasurementMeasuresMental disordersMethodsModalityModelingMonkeysNeuronsNeurosciencesNoiseOperative Surgical ProceduresPatternPerformancePhysiologicalPositioning AttributeReproducibilityResearchResolutionRestRodentSignal TransductionSolidStructureSystemTechniquesTestingThickTimeTracerTranslatingTranslational ResearchValidationawakebonebrain volumecognitive processconnectomedesignexhaustionexperimental studyhigh resolution imaginghuman modelin vivoinformation processinginnovationmagnetic fieldminiaturizeneuroimagingnext generationnonhuman primatenovelradio frequencyresponsesample fixationtooltranslational modelultra high resolution
项目摘要
PROJECT SUMMARY
Ultra high field neuroimaging in humans enables unprecedented resolutions that enable, for the
first time, the non invasive investigation of directional information processing in vivo. These
advances result from the ability of high resolutions to uncover layer specific (feedforward,
feedback) activation patterns. These tools however are not validated in translational models that
mimic human brain function. The reason for that is primarily due to our current inability to
obtain functional magnetic resonance imaging (fMRI) signals at resolutions high enough to resolve
layer specific responses in the non human primate. This project aims at developing novel and
innovative radiofrequency hardware and using it at the ultra high field strength of 10.5 Tesla to
directly test how well whole brain directional connectivity estimates from fMRI correspond with
ground truth tract tracing experiments. This development and validation can directly aid us in
translating findings from the animal model into future studies of the mesoscopic circuit effects of
human mental illness.
项目摘要
人类超高场神经成像实现了前所未有的分辨率,
首次在活体上对定向信息处理进行了无创研究。这些
进步源于高分辨率揭示层特定的能力(前馈,
反馈)激活模式。然而,这些工具没有在转换模型中得到验证,
模仿人脑功能原因主要是我们目前无法
以足够高的分辨率获得功能性磁共振成像(fMRI)信号,
非人类灵长类动物的层特异性反应。该项目旨在开发新的和
创新的射频硬件,并在10.5特斯拉的超高场强下使用它,
直接测试功能磁共振成像对全脑方向连接的估计与
地面实况追踪实验。这种开发和验证可以直接帮助我们
将动物模型的发现转化为未来的介观电路效应研究,
人类精神疾病
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jan Zimmermann其他文献
Jan Zimmermann的其他文献
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{{ truncateString('Jan Zimmermann', 18)}}的其他基金
Connectome style neuroimaging in non human primates via novel integrated RF platforms
通过新型集成射频平台对非人类灵长类动物进行连接组型神经成像
- 批准号:
10579305 - 财政年份:2022
- 资助金额:
$ 50.21万 - 项目类别:
Connectome style neuroimaging in non human primates via novel integrated RF platforms
通过新型集成射频平台对非人类灵长类动物进行连接组型神经成像
- 批准号:
10407330 - 财政年份:2022
- 资助金额:
$ 50.21万 - 项目类别:
Neural basis of behavioral timescale coordination
行为时间尺度协调的神经基础
- 批准号:
10542829 - 财政年份:2021
- 资助金额:
$ 50.21万 - 项目类别:
Neural basis of behavioral timescale coordination
行为时间尺度协调的神经基础
- 批准号:
10332070 - 财政年份:2021
- 资助金额:
$ 50.21万 - 项目类别:
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