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Connectome style neuroimaging in non human primates via novel integrated RF platforms

通过新型集成射频平台对非人类灵长类动物进行连接组型神经成像

基本信息

批准号：
10579305
负责人：
Jan Zimmermann
金额：
$ 55.37万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579305
关键词：
Address Anatomy Anesthesia procedures Animal Model Automobile Driving Axon Bone structure Brain Brain region Chronic Communication Custom Databases Development Devices Disease Environment Feedback Foundations Functional Magnetic Resonance Imaging Future Goals Head Health Human Image Implant Investigation Macaca Magnetic Resonance Magnetic Resonance Imaging Maps Measurement Measures Mental disorders Methods Modality Modeling Monkeys Neurons Neurosciences Noise Operative Surgical Procedures Pattern Performance Physiological Positioning Attribute Reproducibility Research Resolution Rest Rodent Signal Transduction Solid Structure Support System System Techniques Testing Thick Time Tracer Translating Translational Research Validation awake bone brain volume cognitive process connectome design experimental study high resolution imaging human model in vivo information processing innovation magnetic field miniaturize neuroimaging next generation nonhuman primate novel radio frequency response sample fixation tool translational model transmission process ultra high resolution

项目摘要

PROJECT SUMMARY Ultra high field neuroimaging in humans enables unprecedented resolutions that enable, for the first time, the non invasive investigation of directional information processing in vivo. These advances result from the ability of high resolutions to uncover layer specific (feedforward, feedback) activation patterns. These tools however are not validated in translational models that mimic human brain function. The reason for that is primarily due to our current inability to obtain functional magnetic resonance imaging (fMRI) signals at resolutions high enough to resolve layer specific responses in the non human primate. This project aims at developing novel and innovative radiofrequency hardware and using it at the ultra high field strength of 10.5 Tesla to directly test how well whole brain directional connectivity estimates from fMRI correspond with ground truth tract tracing experiments. This development and validation can directly aid us in translating findings from the animal model into future studies of the mesoscopic circuit effects of human mental illness.

项目总结人类的超高场神经成像可以实现前所未有的分辨率，首次实现体内定向信息处理的非侵入性研究。这些进展源于高分辨率揭示特定层(前馈、反馈)激活模式的能力。然而，这些工具并没有在模拟人脑功能的转换模型中得到验证。其原因主要是因为我们目前无法获得足够高分辨率的功能性磁共振成像(FMRI)信号，以解析非人类灵长类动物的层特异性反应。该项目旨在开发新颖和创新的射频硬件，并在10.5特斯拉的超高场强下使用它来直接测试从功能磁共振成像估计的全脑方向连接与地面真相轨迹追踪实验的一致性。这种发展和验证可以直接帮助我们将动物模型的发现转化为未来对人类精神疾病中观回路效应的研究。