Functional Limitations and Disability Among Middle-Aged Adults

项目摘要/摘要 功能限制(基本身体动作的限制)和残疾(日常生活问题)的负担 活动和参与生活)在美国中年成年人中可能比以前认识到的更常见。 然而，对中年人群的研究通常不包括功能评估。《冠脉》 青年动脉风险发展(CARDIA)研究提供了研究功能性的独特机会 在一个多样化、老龄化的队列中的地位。35年的面对面考试计划在2020年和2021年进行，届时， 参赛者年龄在53岁至65岁之间。我们建议进行一项CARDIA辅助研究，通过以下方式获得功能测量 自我报告和体能表现要与从成年初期到 中年应解决以下目标：1.量化#年功能限制和残疾的负担 并评估这在多大程度上可归因于慢性病的积累。 为了评估体能表现与自我报告所反映的功能局限和残疾领域， 3.确定中年功能受限和残疾的成年早期健康相关危险因素， 4.确定与健康有关的、社会经济和心理社会因素，这些因素有助于在--和--内部-- 中年人功能受限和残疾的种族差异。我们将增加措施， 身体表现(快速和正常的步速，单腿平衡，定时椅子站立，6分钟步行测试， 和握力)进入CARDIA第35年考试(预计N=3,270；1,563黑人，1,707白人)。此外，自我- 报告的功能限制(患者报告的结果测量信息系统[PROMIS] 身体功能(缩写为20a)和残疾测量(日常生活的基本和工具性活动)将 被添加到35年考试和每年的电话通话中(35年考试前1个电话，35年考试后2个电话)。AS 对年轻人群的研究通常不包括功能评估、概念化、 测量方法、风险因素以及功能受限和残疾的影响很差 明白了。通过向持续人口添加适当的功能措施来填补这一知识缺口 基于队列，这代表了下一波老龄化的黑人和白人成年人将导致新的方法 防止功能衰退，改善人口健康。

Project summary/Abstract The burden of functional limitations (restrictions in basic physical actions) and disability (problems with daily activities and life participation) may be more common in middle-aged US adults than previously recognized. However, studies of middle-age populations have not typically included functional assessments. The Coronary Artery Risk Development in Young Adults (CARDIA) study provides a unique opportunity to study functional status in a diverse, aging cohort. The Year 35 in-person exam is scheduled for 2020 and 2021, at which time, participants will be 53 to 65 years old. We propose a CARDIA ancillary study to obtain measures of function by self-report and physical performance to be paired with the existing data collected from early adulthood through middle age to address the following aims: 1. To quantify the burden of functional limitations and disability in middle age and assess the degree to which this can be attributed to the accumulation of chronic conditions, 2. To assess domains of functional limitations and disability captured by physical performance versus self-report, 3. To identify health-related risk factors in early adulthood for functional limitations and disability in middle-age, 4. To identify health-related, socioeconomic, and psychosocial factors that contribute to between- and within- race differences in functional limitations and disability among middle-aged adults. We will add measures of physical performance (fast and usual gait speed, single leg balance, timed chair stands, 6-minute walk test, and grip strength) to the CARDIA Year 35 exam (projected N=3,270; 1,563 black, 1,707 white). Also, self- reported functional limitations (Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function Short Form 20a) and disability measures (basic and instrumental activities of daily living) will be added to the Year 35 exam and annual telephone calls (1 call prior to and 2 after the Year 35 exam). As studies of younger populations have not often included functional assessments, the conceptualization, measurement approaches, risk factors, and implications of functional limitations and disability are poorly understood. Filling this knowledge gap by adding appropriate functional measures to an ongoing population based cohort, that represents the next wave of aging black and white adults will lead to new approaches to prevent functional decline and improve population health.