Functional Limitations and Disability Among Middle-Aged Adults

中年成人的功能限制和残疾

• 批准号: 10542421
• 负责人: Christopher Barrett Bowling
• 金额: $ 45.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542421
• 关键词: Activities of Daily Living; Address; Adult; Age; Age Years; Aging; Ancillary Study; Black Populations; Blood Pressure; Cardiovascular Diseases; Caring; Chronic; Cognitive; Coronary Artery Risk Development in Young Adults Study; Data; Development; Diabetes Mellitus; Enrollment; Equilibrium; Event; Gait speed; Geriatrics; Glucose; Hand Strength; Health; Healthcare; Individual; Information Systems; Injury; Knowledge; Leg; Life; Measurement; Measures; Medicare; Obesity; Participant; Pathway interactions; Patient Outcomes Assessments; Patient Self-Report; Persons; Phenotype; Physical Function; Physical Performance; Physical activity; Physiological; Population; Population Study; Prevalence; Psychosocial Factor; Race; Rehabilitation therapy; Reporting; Risk Factors; Role; Schedule; Socioeconomic Factors; Telephone; Testing; Time; Walking; Weight Gain; Woman; aging population; body system; clinical care; cohort; cost; design; disability; emerging adult; follow-up; functional decline; functional improvement; functional status; human old age (65+); instrumental activity of daily living; men; middle age; multiple chronic conditions; neglect; novel strategies; population based; population health; prevent; public health relevance; racial difference; racial disparity; sedentary lifestyle

Project summary/Abstract The burden of functional limitations (restrictions in basic physical actions) and disability (problems with daily activities and life participation) may be more common in middle-aged US adults than previously recognized. However, studies of middle-age populations have not typically included functional assessments. The Coronary Artery Risk Development in Young Adults (CARDIA) study provides a unique opportunity to study functional status in a diverse, aging cohort. The Year 35 in-person exam is scheduled for 2020 and 2021, at which time, participants will be 53 to 65 years old. We propose a CARDIA ancillary study to obtain measures of function by self-report and physical performance to be paired with the existing data collected from early adulthood through middle age to address the following aims: 1. To quantify the burden of functional limitations and disability in middle age and assess the degree to which this can be attributed to the accumulation of chronic conditions, 2. To assess domains of functional limitations and disability captured by physical performance versus self-report, 3. To identify health-related risk factors in early adulthood for functional limitations and disability in middle-age, 4. To identify health-related, socioeconomic, and psychosocial factors that contribute to between- and within- race differences in functional limitations and disability among middle-aged adults. We will add measures of physical performance (fast and usual gait speed, single leg balance, timed chair stands, 6-minute walk test, and grip strength) to the CARDIA Year 35 exam (projected N=3,270; 1,563 black, 1,707 white). Also, self- reported functional limitations (Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function Short Form 20a) and disability measures (basic and instrumental activities of daily living) will be added to the Year 35 exam and annual telephone calls (1 call prior to and 2 after the Year 35 exam). As studies of younger populations have not often included functional assessments, the conceptualization, measurement approaches, risk factors, and implications of functional limitations and disability are poorly understood. Filling this knowledge gap by adding appropriate functional measures to an ongoing population based cohort, that represents the next wave of aging black and white adults will lead to new approaches to prevent functional decline and improve population health.

项目概要/摘要 功能限制（基本身体活动的限制）和残疾（日常活动问题）的负担 活动和生活参与）在美国中年成年人中可能比以前认识到的更为普遍。 然而，对中年人群的研究通常不包括功能评估。冠状动脉 年轻人动脉风险发展 (CARDIA) 研究提供了研究功能性动脉风险的独特机会 在多样化的老龄化群体中的地位。 35 年级现场考试计划于 2020 年和 2021 年举行，届时， 参与者年龄在53岁至65岁之间。我们提出一项 CARDIA 辅助研究，通过以下方式获得功能测量值： 自我报告和身体表现将与从成年早期收集到的现有数据相匹配 中年期旨在实现以下目标： 1. 量化功能限制和残疾的负担 中年并评估这在多大程度上可归因于慢性病的积累，2。 为了评估通过身体表现与自我报告捕获的功能限制和残疾领域， 3. 确定成年早期导致中年功能受限和残疾的健康相关危险因素， 4. 确定导致内部和内部的健康相关、社会经济和社会心理因素 中年成年人功能限制和残疾的种族差异。我们将增加以下措施 身体表现（快速和正常的步态速度、单腿平衡、定时椅子站立、6 分钟步行测试、 和握力）参加 CARDIA 35 年级考试（预计 N=3,270；1,563 名黑人，1,707 名白人）。还有，自 报告的功能限制（患者报告的结果测量信息系统 [PROMIS] 身体功能简表 20a) 和残疾措施（日常生活的基本和工具性活动）将 添加到 35 年级考试和年度电话通话中（35 年级考试之前 1 次，之后 2 次）。作为 对年轻人的研究通常不包括功能评估、概念化、 测量方法、风险因素以及功能限制和残疾的影响都很差 明白了。通过向现有人口添加适当的功能措施来填补这一知识空白 代表下一波老年黑人和白人成年人的群体将带来新的方法 防止功能衰退并改善人群健康。

项目成果

Unintended Consequences of COVID-19 Social Distancing Among Older Adults With Kidney Disease.

COVID-19的意外后果在患有肾脏疾病的老年人中的社会疏远。

• DOI: 10.1093/gerona/glab211
• 发表时间: 2022-04-01
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Bowling CB;Berkowitz TSZ;Smith B;Whitson HE;DePasquale N;Wang V;Maciejewski ML;Olsen MK
• 通讯作者: Olsen MK

Insomnia Diagnosis, Prescribed Hypnotic Medication Use, and Risk for Serious Fall Injuries in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

中风地理和种族差异原因 (REGARDS) 研究中的失眠诊断、处方催眠药物的使用以及严重跌倒受伤的风险。

• DOI: 10.1093/sleep/zsac063
• 发表时间: 2022
• 期刊: Sleep
• 影响因子: 5.6
• 作者: Thomas,SJustin;Sakhuja,Swati;Colantonio,LisandroD;Li,Mei;Muntner,Paul;Reynolds,Kristi;Bowling,CBarrett
• 通讯作者: Bowling,CBarrett

Sustained SBP control and long-term nursing home admission among Medicare beneficiaries.

• DOI: 10.1097/hjh.0000000000002926
• 发表时间: 2021-11-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Bowling, C. Barrett;Sloane, Richard;Pieper, Carl;Luciano, Alison;Davis, Barry R.;Simpson, Lara M.;Einhorn, Paula T.;Oparil, Suzanne;Muntner, Paul
• 通讯作者: Muntner, Paul

Changes in Fall Rates From Before to During the COVID-19 Pandemic: Findings From the Prospective AMBROSIA Study.

• DOI: 10.1093/gerona/glac131
• 发表时间: 2023-03-30
• 期刊: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
• 影响因子: 5.1
• 作者: Bowling, C. Barrett;Wei, Rong X.;Qian, Lei;Shimbo, Daichi;Schwartz, Joseph E.;Muntner, Paul;Cannavale, Kimberly L.;Harrison, Teresa N.;Reynolds, Kristi
• 通讯作者: Reynolds, Kristi