UNC Geriatric Oncology Training Grant (UNC-GO)

北卡罗来纳大学老年肿瘤学培训补助金（UNC-GO）

• 批准号: 10541849
• 负责人: JAN BUSBY-WHITEHEAD
• 金额: $ 13万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541849
• 关键词: Elderly; Grant; Oncology; Training

ABSTRACT Cancer is a disease of aging, with incidence and mortality rates rising dramatically with increasing age. In the U.S., the average age at a cancer diagnosis is 66 years; of the 1,688,780 new cancer cases in 2017, more than 53% are adults age 65 years and older. Sixty-two percent of current survivors are age >65, and will rise to 73% by 2040. These numbers, coupled with aging trends of the U.S. population, portend large and growing cohorts of older cancer patients and survivors in the years to come. Cancer treatment in the older population is challenging and complicated by factors related to co-morbidity, functional status, polypharmacy, social support, nutritional status, and other geriatric relevant domains. Our ability to provide personalized and appropriate cancer care to our rapidly expanding older population is challenged by a shortage of geriatricians to team with oncologists, inadequate geriatrics training of oncologists, and cancer clinical trials that have focused largely on younger patients and have generated little data on elders who are more likely to have multiple comorbidities and varying goals of care. The UNC Geriatric Oncology Training Grant (UNC-GO) is a T32 training application from the University of North Carolina at Chapel Hill (UNC) specifically focused on training physicians in clinical/translational or health services research at the interface of geriatrics and oncology. Co-directed by renowned leaders in oncology (Hyman B. Muss, MD) and geriatrics (Jan Busby-Whitehead, MD), UNC-GO will provide two years of training (one new trainee per year) in geriatric oncology research for residents and fellows training in Geriatrics or Medical, Surgical, Gynecologic, Radiation, or Urologic Oncology. UNC-GO trainees will benefit from access to resources and expertise available through the UNC Lineberger Comprehensive Cancer Center (UNC-LCCC), which received an “exceptional” score of 11 during its most recent review, as well as the UNC-LCCC Geriatric Oncology Program (co-directed by Drs. Muss and Busby-Whitehead) and the UNC Center on Aging and Health (director by Dr. Busby-Whitehead). UNC-GO primary preceptors are UNC-LCCC members and have on average $1.1 million in annual research funding. Upon the trainee’s admission to the program, the UNC-GO Co-Directors and Steering Committee work with the trainee to form a mentorship team that includes a clinician/scientist with Geriatrics expertise. The central component of UNC-GO training is the mentored research experience. Trainees will choose between two research tracks that represent the best research areas that UNC has to offer: clinical/translational and health services research. Under the guidance of the mentoring team, trainees design and conduct one or more independent projects. Trainees address aspects of research ranging from developing the research question and design, to the protocol, methods, instruments, data collection/compilation, data management, analysis, and reporting. Involvement of collaborating experts is expected. Trainees are expected to present their research findings at local, regional, and national scientific meetings, and to have a minimum of one first-author manuscript submitted per year.

摘要 癌症是一种衰老性疾病，随着年龄的增长，发病率和死亡率急剧上升。在 美国，癌症诊断的平均年龄为66岁;在2017年的1，688，780例新癌症病例中， 53%是65岁及以上的成年人。目前62%的幸存者年龄>65岁，并将上升到73%。 到2040年这些数字，加上美国人口的老龄化趋势，预示着大量和不断增长的队列 老年癌症患者和幸存者的生活。老年人的癌症治疗 具有挑战性，并因合并症、功能状态、多种药物、社会支持 营养状况和其他老年相关领域。我们能够提供个性化和适当的癌症 护理我们迅速扩大的老年人口面临着老年病医生短缺的挑战， 肿瘤学家，肿瘤学家的老年医学培训不足，以及癌症临床试验主要集中在 年轻患者，并且很少有关于老年人的数据，老年人更有可能患有多种合并症， 不同的护理目标。老年肿瘤学培训补助金（UNC-GO）是T32培训申请， 位于查佩尔山的北卡罗来纳州大学专门致力于培训医生， 在老年医学和肿瘤学的界面上进行临床/转化或卫生服务研究。联合导演： 著名的肿瘤学领导者（Hyman B. Muss，医学博士）和老年医学（Jan Busby-Whitehead，医学博士），UNC-GO将 为住院医师和研究员提供两年的老年肿瘤学研究培训（每年一名新学员） 接受过老年病学或内科、外科、妇科、放射或泌尿肿瘤学的培训。UNC-GO学员将 受益于通过Lineberger综合癌症中心获得的资源和专业知识 该中心（UNC-LCCC）在最近的审查中获得了11分的“特殊”分数， UNC-LCCC老年肿瘤学项目（由Muss博士和Busby-Whitehead博士共同指导） 《老龄化与健康》（Dr. Busby-Whitehead）UNC-GO的主要导师是UNC-LCCC成员 平均每年有110万美元的研究经费。在学员被录取参加该计划后， UNC-GO联合主任和指导委员会与受训人员合作，组成一个指导小组，其中包括 具有老年医学专业知识的临床医生/科学家。UNC-GO培训的核心组成部分是指导研究 体验.学员将选择两个研究轨道，代表最好的研究领域， 必须提供：临床/转化和卫生服务研究。在导师团队的指导下， 学员设计并开展一个或多个独立项目。学员讨论研究的各个方面，包括 从开发研究问题和设计，到方案，方法，仪器，数据 收集/汇编、数据管理、分析和报告。合作专家的参与是 预期受训者将在当地、地区和国家科学会议上展示他们的研究成果。 每年至少提交一份第一作者手稿。

项目成果

Interplay of Oncoplastic Reconstruction and Adjuvant Radiation Therapy in Breast Cancer.

乳腺癌肿瘤整形重建与辅助放射治疗的相互作用。

• DOI: 10.1016/j.adro.2023.101403
• 发表时间: 2024
• 期刊: Advances in radiation oncology
• 影响因子: 2.3
• 作者: Morse,RyanT;Moreno,Matthew;Butterworth,JamesA;Mitchell,MelissaP
• 通讯作者: Mitchell,MelissaP

Supportive Care and Symptom Management for Patients With Immunoglobulin Light Chain (AL) Amyloidosis.

• DOI: 10.3389/fonc.2022.907584
• 发表时间: 2022
• 期刊: FRONTIERS IN ONCOLOGY
• 影响因子: 4.7
• 作者: Jensen, Christopher E.;Byku, Mirnela;Hladik, Gerald A.;Jain, Koyal;Traub, Rebecca E.;Tuchman, Sascha A.
• 通讯作者: Tuchman, Sascha A.

Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study.

• DOI: 10.1016/j.xfre.2020.10.005
• 发表时间: 2021-03
• 期刊: F&S reports
• 作者: Kahn JL;Buckingham L;Koelper NC;Sammel MD;Shah DK
• 通讯作者: Shah DK

Radiosensitivity of Breast Cancer Cells Is Dependent on the Organ Microenvironment.

• DOI: 10.3389/fonc.2022.833894
• 发表时间: 2022
• 期刊: Frontiers in oncology
• 影响因子: 4.7