The Network for Investigation of Delirium: Unifying Scientists (NIDUS)'s 9th-13th Annual Delirium Boot Camps: A Foundation for Future Exploration

谵妄调查网络：联合科学家 (NIDUS) 的第 9 至 13 届年度谵妄训练营：未来探索的基础

• 批准号: 10378656
• 负责人: JAN BUSBY-WHITEHEAD
• 金额: $ 5万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378656
• 关键词: Acute; Acute Disease; Address; Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Animal Model; Area; Attention; Award; Bibliography; Big Data; COVID-19; COVID-19 complications; Caliber; Clinical; Clinical Research; Cognition; Cognition Disorders; Collaborations; Communities; Community Networks; Complex; Complication; Delirium; Discipline; Education; Elderly; Ensure; Epidemiology; Faculty; Feedback; Fostering; Foundations; Funding; Future; Goals; Grant; Health Expenditures; Infrastructure; Institution; International; Investigation; Knowledge; Laboratories; Machine Learning; Measurement; Mentors; Mentorship; Methodology; Methods; Monoclonal Antibody R24; National Institute on Aging; Network Infrastructure; Operative Surgical Procedures; Paper; Participant; Peer Review; Pilot Projects; Public Health; Publications; Publishing; Reporting; Research; Research Methodology; Research Personnel; Resources; SARS-CoV-2 infection; Science; Scientific Advances and Accomplishments; Scientist; Series; Societies; Study Section; Training; United States National Institutes of Health; Writing; career; career development; clinical practice; cost; innovation; interdisciplinary collaboration; lectures; meetings; multidisciplinary; neglect; next generation; patient population; peer; programs; randomized trial; response; secondary analysis; senior faculty; skill acquisition; success; support network; symposium; systematic review; webinar; working group

Delirium is a serious cognitive disorder associated with Alzheimer’s disease and related dementias (ADRD) that affects ~2.6 million older adults yearly. It is a frequent complication of acute illness, surgery and, now, of COVID-19 infection in older adults. Recognizing the relative dearth of delirium research, the National Institute for Aging (NIA) supported the establishment of the Network for Investigation of Delirium: Unifying Scientists (NIDUS), a collaborative interdisciplinary group of 28 investigators, from 27 institutions, to advance delirium research and develop network infrastructure. This included the creation of an annual “NIDUS bootcamp” conference, to bring together the growing national- and international delirium research community for networking and education. The bootcamp aims are to advance the science of the field and to provide junior investigators with intensive mentorship, through mock NIH application reviews, clinical and research lectures, breakout sessions, and post-bootcamp networking. Bootcamp alumni are provided guidance on: 1) using the NIDUS Delirium Research Hub, Measurement resources and Bibliography, 2) submitting proposals to the NIDUS Pilot Program (13 one-year $50,000 grants awarded), NIA GEMSSTAR/CLINSTAR, the Alzheimer’s Association, and other foundations, 3) attending Mentoring webinars, 4) participating in Junior Faculty Working Groups, and 5) submitting research abstracts to the American Delirium Society (ADS) Annual Meeting. As PIs, 94 alumni have received 46 grants, of which 18 (40%) were NIH-funded, and published 265 original peer- reviewed articles. NIDUS has jumpstarted the careers of many young investigators, particularly bootcamp alumni, enabling them to launch independent programs in delirium research. The goal of this application is to support continuation of a yearly, themed Delirium Bootcamp Conference (DBC), to ensure that the progress of this active research community is sustained. The first-year theme will be the inter-relationship between delirium and ADRD. The Specific Aims are to: (1) Engage and support junior investigators in delirium research through mentorship and access to the NIDUS resources/network (2) Boost the researchers’ funding success (3) Facilitate publication of delirium research and provide ongoing mentorship, and (4) Facilitate networking among junior, mid-career, and senior researchers during and after DBC. As the pool of delirium investigators expands, there is a critical need for a conference focused on addressing cutting-edge research methods in all areas of delirium research, including the relationship with ADRD, “-Omics” research, machine learning and big data, innovations in randomized trials, animal models and mechanistic research, and clinical practice improvement. The DBC will provide an unparalleled opportunity to advance cutting-edge delirium research through interactive didactic sessions and in-depth guidance on complex and nuanced research methods essential for the highest caliber and most impactful delirium research.

谵妄是一种与阿尔茨海默病和相关痴呆症 (ADRD) 相关的严重认知障碍 每年影响约 260 万老年人。它是急性疾病、手术以及现在的常见并发症。 老年人感染 COVID-19。认识到谵妄研究相对缺乏，国家研究所 老龄化组织 (NIA) 支持建立谵妄调查网络：团结科学家 (NIDUS)，一个由来自 27 个机构的 28 名研究人员组成的跨学科协作小组，旨在促进谵妄的发展 研究和开发网络基础设施。其中包括创建年度“NIDUS 训练营” 会议，汇集不断壮大的国内和国际谵妄研究界 网络和教育。该训练营的目的是推进该领域的科学发展并为初级学生提供 通过模拟 NIH 申请审查、临床和研究讲座，对研究人员进行深入指导， 分组会议和训练营后网络。训练营校友将获得以下方面的指导：1) 使用 NIDUS Delirium 研究中心，测量资源和参考书目，2) 向 NIDUS 试点计划（授予 13 个为期一年 50,000 美元的资助）、NIA GEMSSTAR/CLINSTAR、阿尔茨海默病 协会和其他基金会，3) 参加指导网络研讨会，4) 参与初级教师工作 小组，以及 5) 向美国谵妄协会 (ADS) 年会提交研究摘要。作为 PI， 94 名校友获得了 46 项资助，其中 18 项（40%）是 NIH 资助的，并发表了 265 篇原创同行论文 审阅的文章。 NIDUS 启动了许多年轻调查员的职业生涯，尤其是训练营 校友，使他们能够启动谵妄研究的独立项目。 此应用程序的目标是支持每年一度的主题 Delirium 训练营会议的继续 （DBC），以确保这个活跃的研究团体能够持续取得进展。第一年的主题是 谵妄与 ADRD 之间的相互关系。具体目标是： (1) 吸引和支持初级人员 通过指导和访问 NIDUS 资源/网络进行谵妄研究的调查员 (2) Boost 研究人员的资助成功 (3) 促进谵妄研究的发表并提供持续的 指导，以及 (4) 促进初级、职业中期和高级研究人员在工作期间和之后建立联系 数据库。随着谵妄调查人员队伍的扩大，迫切需要召开一次重点关注的会议 探讨谵妄研究所有领域的前沿研究方法，包括与 ADRD、“组学”研究、机器学习和大数据、随机试验创新、动物模型和 机理研究和临床实践改进。 DBC 将提供无与伦比的机会 通过互动教学课程和深入指导来推进尖端谵妄研究 复杂而细致的研究方法对于最高水平和最具影响力的谵妄研究至关重要。