Delineation of tumor, stromal and immune transcriptomes at the infiltrating interface of muscle invasive bladder cancer
肌肉浸润性膀胱癌浸润界面的肿瘤、基质和免疫转录组的描绘
基本信息
- 批准号:10543535
- 负责人:
- 金额:$ 21.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-22 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:Automobile DrivingBioinformaticsBiological ProcessBladderCancer EtiologyCancer PatientCandidate Disease GeneCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCessation of lifeClinicalCollectionComplexData SetDevelopmentDiagnosisDiseaseDistantFutureGene ExpressionGene Expression ProfileGenesGenetic TranscriptionGenomicsHeterogeneityHumanImmuneIndividualInfiltrationInvadedMalignant neoplasm of urinary bladderMicrodissectionMolecularMolecular ProfilingMuscleMutationOperative Surgical ProceduresPatientsPopulationProcessPublic HealthPublishingRegulator GenesRelapseResearchSamplingSubmucosaSuspensionsTumor Cell Invasionbiomarker developmentbiomarker identificationcancer cellcell typegene networkimmune cell infiltrateimprovedinsightmuscle invasive bladder cancerneoplastic cellnew therapeutic targetpotential biomarkerpredictive markerprogramssegregationsingle-cell RNA sequencingtranscriptometranscriptome sequencingtranscriptomic profilingtranscriptomicstumor
项目摘要
Project Summary
The presence of tumor invasion into the submucosal muscle of the bladder defines the progression from
nonlethal to lethal bladder cancer; however, this process is not well understood at the molecular level. Genomic
and transcriptomic profiling of muscle invasive bladder cancer (MIBC) has recently identified mutations and gene
expression profiles associated with established MIBC. Although a major advancement in the bladder cancer
field, these analyses were unable to determine the unique transcriptional programs activated in individual tumor,
stromal and immune populations at the invasive interface of MIBC. This was primarily due to the limitations of
accurate spatial collection of infiltrating tumor and adjacent/intermingled stroma and infiltrating immune cells. As
a result, earlier transcriptomic studies and even recent studies using single cell RNAseq relied on heterogeneous
bulk tumor, which includes both noninvasive as well as normal stroma and immune components spatially distant
from the invasive border. This heterogeneity makes it difficult to accurately de-convolute gene expression
signatures unique to tumor cells, stroma and infiltrating immune cells in the immediate invasive micro-
environment. We hypothesize that distinct gene networks are activated in individual tumor, stromal and
immune populations at the invasive interface of MIBC. RNAseq profiling and bioinformatic analysis should
reveal enriched and distinct transcriptomic signatures from the individual populations. This research would
provide positive impact by identifying cellular and molecular signatures of distinct cellular populations driving
invasive progression. These findings could then lead to examination of candidate gene networks that will serve
as the basis for biological function, potential biomarker identification and new therapeutic targets that are needed
for bladder cancer patients who have been diagnosed with or have relapsed with muscle invasive disease.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('MARK L DAY', 18)}}的其他基金
Delineation of tumor, stromal and immune transcriptomes at the infiltrating interface of muscle invasive bladder cancer
肌肉浸润性膀胱癌浸润界面的肿瘤、基质和免疫转录组的描绘
- 批准号:
10353062 - 财政年份:2021
- 资助金额:
$ 21.44万 - 项目类别:
The Role of ADAM15 in Prostate Tumor Intravazation and Metastasis
ADAM15 在前列腺肿瘤浸润和转移中的作用
- 批准号:
8096777 - 财政年份:2010
- 资助金额:
$ 21.44万 - 项目类别:
The Role of ADAM15 in Prostate Tumor Intravazation and Metastasis
ADAM15 在前列腺肿瘤浸润和转移中的作用
- 批准号:
8256675 - 财政年份:2010
- 资助金额:
$ 21.44万 - 项目类别:
The Role of ADAM15 in Prostate Tumor Intravazation and Metastasis
ADAM15 在前列腺肿瘤浸润和转移中的作用
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8460156 - 财政年份:2010
- 资助金额:
$ 21.44万 - 项目类别:
The Role of ADAM15 in Prostate Tumor Intravazation and Metastasis
ADAM15 在前列腺肿瘤浸润和转移中的作用
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8658029 - 财政年份:2010
- 资助金额:
$ 21.44万 - 项目类别:
University of Michigan O'Brien Center for Urology Research
密歇根大学奥布莱恩泌尿学研究中心
- 批准号:
7500607 - 财政年份:2007
- 资助金额:
$ 21.44万 - 项目类别:
University of Michigan O'Brien Center for Urology Research
密歇根大学奥布莱恩泌尿学研究中心
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7500605 - 财政年份:2007
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Rb/E2F in Hormone signaling of Prostate Epithelium
前列腺上皮激素信号传导中的 Rb/E2F
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7053355 - 财政年份:2004
- 资助金额:
$ 21.44万 - 项目类别:
Rb/E2F in Hormone signaling of Prostate Epithelium
前列腺上皮激素信号传导中的 Rb/E2F
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6881046 - 财政年份:2004
- 资助金额:
$ 21.44万 - 项目类别:
Rb/E2F in Hormone Signaling of Prostate Epithelium
前列腺上皮激素信号转导中的 Rb/E2F
- 批准号:
6704381 - 财政年份:2004
- 资助金额:
$ 21.44万 - 项目类别:
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