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Simulation Modeling to Understand and Address HIV Disparities in Racial, Ethnic, and Sexual Minority Populations

通过模拟建模来理解和解决种族、民族和性别少数群体中的艾滋病毒差异

基本信息

批准号：
10543985
负责人：
Michelle Birkett
金额：
$ 40.1万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-02 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10543985
关键词：
Address Affect Black race Chicago Church Cities Communicable Diseases Communities Complex Data Data Set Disease Disease Outbreaks Disparity Distal Ebola Etiology Fostering Friends Funding Geography Grouping HIV HIV disparities Hispanic Home Homophobia Household Individual Inequity Infection Influenza Intervention Laboratories Lesbian Gay Bisexual Transgender Life Minority Groups Modeling Movement Nature Neighborhoods Pathway interactions Pattern Persons Phase Population Population Dynamics Prevention Prevention strategy Public Health Race Racial Segregation Reduce health disparities Research Research Personnel Resources Risk Route Shapes Social Environment Social Interaction Social Work System Testing Time United States National Institutes of Health Universities Workplace black men who have sex with men disease disparity disease transmission disparity reduction ethnic minority ethnic minority population flexibility health disparity populations marginalization marginalized population men who have sex with men methicillin resistant Staphylococcus aureus model building models and simulation novel population based preference racial difference racial disparity racial diversity racial minority racism sexual minority sexual minority group simulation social sociologist therapy development transmission process

项目摘要

Project Summary Racial, ethnic, and sexual minority populations are disproportionately impacted by infectious disease, particularly HIV. Individuals at the intersection of multiple of these marginalized identities are even more likely to be impacted by HIV – especially Black and Hispanic men who have sex with men. While there is growing evidence that the day-to-day life of racial and sexual minorities differs from majority populations, there is a limited understanding of how differences in neighborhoods, differences in places where time is spent, and differences in the kinds of people connected with may impact disease spread and fuel disparities. Moreover, there is even less comprehensive understanding of how public health strategies could be refined to specifically reduce health disparities. Simulation models that accurately replicate population dynamics by simulating the movement and interaction of millions of individuals allow researchers a toolbox to understand the underlying dynamics of disease transmission and identify potential targets for intervention. This project joins two complementary teams of researchers in Chicago to build chiSTIG, a simulation model specifically derived to understand the social contextual dynamics which lead to disparities in HIV. The first team, at Northwestern University, have been funded by the NIH to capture rich data on the social systems and physical spaces inhabited by racial and sexual minorities, and have utilized these data to understand how the social and sexual isolation of young Black men who have sex with men (BMSM) in Chicago drives disparities in HIV. The second team, at the University of Chicago/Argonne National Laboratory, have built chiSIM, an extraordinarily powerful agent-based modeling (ABM) framework that simulates the interaction of 2.9 million Chicagoans across 1.2 million geo-located places to understand disease outbreaks and guide intervention development. chiSIM is a flexible system that has been used to understand prevention strategies for a number of infectious diseases. We propose to utilize several existing rich empirical datasets to build a chiSIM-derived model, chiSTIG, so that it might serve as a counterfactual laboratory able to test competing hypotheses regarding the etiology of infectious disease inequities in HIV for sexual minorities, specifically Black and Hispanic MSM, and potential routes for intervention. Specifically, the framework will be extended through the integration of detailed data on the physical and online third places utilized by and the social and sexual interactions of racially diverse MSM in Chicago.

项目总结