1/2-Testing the impact of early screening on the long-term outcomes of children with ASD

1/2-测试早期筛查对自闭症儿童长期结果的影响

基本信息

  • 批准号:
    10543107
  • 负责人:
  • 金额:
    $ 88.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-03-05 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Autism spectrum disorder (ASD) impacts almost 2% of children born today, yet very little is known regarding how to positively alter the outcomes of affected children. On the one hand, many, including the American Academy of Pediatrics, believe that early universal screening at well baby check‐ups is an important step towards a positive outcome because it can lead to early treatment. In contrast, the United States Preventive Services Task Force (USPSTF) recently failed to endorse early universal ASD screening, noting that the benefits of doing so are poorly understood. What is needed to inform the debate is to examine the outcomes of a large cohort of children detected very early via universal screening at well‐baby checks, and to compare them to children who did not participate in an early detection program. Here we propose to do just that: We will examine the school age outcomes (age 6‐10 years) of an unprecedented sample size of 242 children with ASD detected very early in San Diego and Phoenix (i.e., “west coast cohort”) through our Get SET Early program, which involved screening with the CSBS at well baby check‐ ups (mean age 17.7 months, range 12‐24 months), and immediate referral for comprehensive evaluation and treatment if warranted. They will then be compared to a cohort of 242 ASD community children matched on age, gender, race, ethnicity, and SES who did not participate in our early detection program (Total N = 484). Given the rarity and uniqueness of our cohort, we plan to characterize outcomes not only on traditional measures of cognition, social behavior, etc., but also on outcome on school achievement (e.g., fully mainstreamed and/or lost their diagnosis) and family functioning (do families experience less stress?). Since the national mean age of ASD diagnosis is around 4 years, we expect that children in the community cohort will have later ages of diagnosis and poorer outcomes than those identified early via the Get SET Early program. With scientific rigor and reproducibility in mind, we will proactively test the replication of findings in an independent cohort (N=103) of toddlers screened in Boston, Philadelphia, and New Haven (i.e., “east coast cohort”) through Project Early and a matched community cohort from the same region (Total N=120). Our specific aims are: AIM 1a: we will identify clinically meaningful outcome subtypes of ASD in our west coast cohort using unbiased network clustering approaches. AIM 1b: with this unique longitudinal cohort, we will examine changes in symptom profile, IQ and adaptive functioning between toddler and school ages. AIM 1c: we will evaluate program impact by comparing the outcomes children in our early‐detected to the community cohort. AIM 1d: we will examine how well findings are replicated in our East coast sample. AIM 2: using complimentary regression and machine learning techniques, with our total sample collapsed across both west and east coast cohorts (N=602), we will test our model that earlier age at identification and treatment leads to improved outcomes. To examine other factors relating to a good outcome, moderating variables such as SES and level of treatment participation will also be included in our models. AIM 3: since state context (e.g., policies, guidelines) could also play a role in outcomes, in we plan to collect key state‐level information to place our findings in context.
自闭症谱系障碍(ASD)影响着今天出生的近2%的儿童,但人们对如何消除自闭症知之甚少

项目成果

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Karen L Pierce其他文献

Karen L Pierce的其他文献

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{{ truncateString('Karen L Pierce', 18)}}的其他基金

Testing the accuracy of eye tracking as a screening tool for ASD in the general population
测试眼动追踪作为普通人群自闭症谱系障碍筛查工具的准确性
  • 批准号:
    10638066
  • 财政年份:
    2023
  • 资助金额:
    $ 88.75万
  • 项目类别:
Discovering Eye Tracking Biomarkers of ASD with Diagnostic and Prognostic Power
发现具有诊断和预后能力的 ASD 眼动追踪生物标志物
  • 批准号:
    10063560
  • 财政年份:
    2019
  • 资助金额:
    $ 88.75万
  • 项目类别:
Discovering Eye Tracking Biomarkers of ASD with Diagnostic and Prognostic Power
发现具有诊断和预后能力的 ASD 眼动追踪生物标志物
  • 批准号:
    10318939
  • 财政年份:
    2019
  • 资助金额:
    $ 88.75万
  • 项目类别:
Discovering Eye Tracking Biomarkers of ASD with Diagnostic and Prognostic Power
发现具有诊断和预后能力的 ASD 眼动追踪生物标志物
  • 批准号:
    10532198
  • 财政年份:
    2019
  • 资助金额:
    $ 88.75万
  • 项目类别:
Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
在 1 岁生日时检测 ASD 作为护理标准:Get SET Early 模型
  • 批准号:
    9320785
  • 财政年份:
    2014
  • 资助金额:
    $ 88.75万
  • 项目类别:
Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
在 1 岁生日时检测 ASD 作为护理标准:Get SET Early 模型
  • 批准号:
    8758746
  • 财政年份:
    2014
  • 资助金额:
    $ 88.75万
  • 项目类别:
Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
在 1 岁生日时检测 ASD 作为护理标准:Get SET Early 模型
  • 批准号:
    8916193
  • 财政年份:
    2014
  • 资助金额:
    $ 88.75万
  • 项目类别:
Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
在 1 岁生日时检测 ASD 作为护理标准:Get SET Early 模型
  • 批准号:
    9611999
  • 财政年份:
    2014
  • 资助金额:
    $ 88.75万
  • 项目类别:
Early Identification of ASD: Translating Eye Tracking into Practice
自闭症谱系障碍 (ASD) 的早期识别:将眼动追踪转化为实践
  • 批准号:
    9297357
  • 财政年份:
    2013
  • 资助金额:
    $ 88.75万
  • 项目类别:
Early Identification of ASD: Translating Eye Tracking into Practice
自闭症谱系障碍 (ASD) 的早期识别:将眼动追踪转化为实践
  • 批准号:
    8852183
  • 财政年份:
    2013
  • 资助金额:
    $ 88.75万
  • 项目类别:

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