Early life trauma and aging using a long-lived animal model
使用长寿动物模型研究早期生命创伤和衰老
基本信息
- 批准号:10550195
- 负责人:
- 金额:$ 13.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-15 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdultAgeAgingAnimal ModelApplications GrantsAreaAutoimmune DiseasesAwardAwarenessBehaviorBiologicalCaringChildChildhoodChronologyCognitionConflict (Psychology)DevelopmentDiabetes MellitusDiseaseDisease ProgressionDisease susceptibilityDoctor of PhilosophyDoseEarly-life traumaEducationEffectivenessElephantsEmotionalEndocrine systemEndocrinologyEnvironmentEthicsEthnic OriginExcisionExerciseExposure toFamilyFamily memberFoodFosteringGeneticGoalsHandHealthHeart DiseasesHumanImmune systemIndividualIntelligenceInterruptionInterventionK-Series Research Career ProgramsLeadLearningLifeLife ExpectancyLongevityMalignant NeoplasmsMemoryMentorshipMethodsModelingMorbidity - disease rateMothersNatural experimentNervous SystemNon-Insulin-Dependent Diabetes MellitusObesityOrphanOrphanagesOutcomeParasitesParentsPersonsPhysiologicalPopulationPost-Traumatic Stress DisordersPredispositionPrevalencePropertyPublic HealthRandomizedResearchResearch PersonnelRiskSamplingScienceScientistSmokingSocioeconomic StatusSourceStrokeSystemTP53 geneTicksTimeTrainingTraining ActivityTraumaVariantWaterWorkZambiaadverse childhood eventsaffiliative behaviorallostasisallostatic loadantisocial behaviorbehavioral healthbiological adaptation to stresscareer developmentcognitive functioncognitive taskdesignearly life exposureexperienceexperimental studyfeasibility testinghealthy agingimprovedinformation gatheringinnovationinsightinter-individual variationlife historymortalitypilot testpoor health outcomepsychobiologypsychologicresponsesexskillssocialsocial health determinantssocial learningsocial normstandard carestressortrait
项目摘要
PROJECT SUMMARY/ABSTRACT
Training: My research over the past eight years has focused primarily on elephant endocrinology, health, and
aging. The work has shown that there are many similarities between elephants and humans (e.g., morbidities,
life history, socialness, emotional complexity), and that leveraging information gathered by studying elephants
may improve human health and aging. The proposed K01 career development training plan builds on that
experience but identifies three areas that require additional training: (1) develop expertise in psychobiology and
behavior, (2) enhance skills in aging science and methods, and (3) build skills in designing and implementing
randomized experiments. Accordingly, we propose intensive topical mentorship, focused coursework, and
contextual learning through the proposed research. This K01 will provide protected time to receive the needed
training to enhance my expertise in these three areas and will propel me to becoming an independent research
scientist focusing on healthy aging. Research: People who have endured adverse childhood experiences
(ACEs) have increased risk of developing physical and psychological diseases later in life. They are 1.6 to 2.4
times more likely to develop obesity, cancer, heart disease, stroke, and diabetes as adults, and life expectancy
is reduced by up to 20 years. Understanding how ACEs lead to disease in adulthood is important for developing
interventions to interrupt disease progression. The proposed K01 attempts to address this need through the
following objectives: to demonstrate the value of using the elephant as a model for human aging, and elucidating
how early-life trauma influences an individual’s biological and social trajectory. Like humans, calves are highly
reliant and bonded to their mother, and can suffer post-traumatic stress disorder after witnessing her killing. The
poaching of random elephants for their tusks has provided a natural experiment to compare highly traumatized
orphaned elephants with non-orphaned elephants in regard to their allostatic load, biological age, cognition, and
disease susceptibility. This will be the first study that we are aware of that uses the elephant to understand the
implications of early-life trauma, while also implementing a randomized experiment. The proposed K01 will not
only demonstrate the value of the elephant to further understand human aging, but it will elucidate how early-life
trauma influences an individual’s biological and social trajectory. Summary: Findings from this study will inform
an R01 grant application to expand the study of early-life trauma and aging using the elephant. This K01 will
develop my new expertise in psychobiology, aging, and randomized experiments. At the end of this award, I will
be a leading independent scientist conducing innovative research in the field of aging.
项目摘要/摘要
培训:在过去的八年里,我的研究主要集中在大象的内分泌学,健康,
衰老这项工作表明,大象和人类之间有许多相似之处(例如,发病率,
生活史,社会性,情感复杂性),并利用研究大象收集的信息,
可以改善人类健康和衰老。拟议的K 01职业发展培训计划建立在这一基础上
经验,但确定需要额外培训的三个领域:(1)发展心理生物学方面的专业知识,
行为,(2)提高衰老科学和方法的技能,(3)建立设计和实施的技能
随机实验因此,我们建议密集的专题辅导,重点课程,
通过所提出的研究进行情境学习。此K 01将提供受保护的时间来接收所需的
培训,以提高我在这三个领域的专业知识,并将推动我成为一个独立的研究
专注于健康老龄化的科学家研究:经历过不良童年经历的人
(ACE)增加了在以后的生活中发展身体和心理疾病的风险。1.6到2.4
成年后患肥胖、癌症、心脏病、中风和糖尿病的可能性增加一倍,
最多能缩短20年了解ACE如何导致成年期疾病对于发展
干预措施,以阻止疾病进展。拟议的K 01试图通过以下方式满足这一需求:
以下目标:证明使用大象作为人类衰老模型的价值,并阐明
早期生活创伤如何影响个体的生物学和社会轨迹。像人类一样,幼鲸
他们依赖母亲,与母亲有着紧密的联系,在目睹母亲被杀后,他们可能会患上创伤后应激障碍。的
偷猎大象的象牙提供了一个自然的实验,
孤儿大象与非孤儿大象在非稳态负荷、生物年龄、认知和
疾病易感性这将是我们所知道的第一个使用大象来了解
早期生活创伤的影响,同时也实施了一项随机实验。建议的K 01不会
这只大象只是证明了进一步了解人类衰老的价值,但它将阐明早期生命是如何
创伤会影响一个人的生理和社会轨迹。摘要:这项研究的结果将为
一份R 01基金申请,用于扩大使用大象进行的早期创伤和衰老研究。K 01将
发展我在心理生物学、衰老和随机实验方面的新专长。在这个奖项的最后,我将
成为在老龄化领域进行创新研究的领先独立科学家。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Daniella E. Chusyd其他文献
Daniella E. Chusyd的其他文献
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{{ truncateString('Daniella E. Chusyd', 18)}}的其他基金
Early life trauma and aging using a long-lived animal model
使用长寿动物模型研究早期生命创伤和衰老
- 批准号:
10369990 - 财政年份:2022
- 资助金额:
$ 13.06万 - 项目类别:
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