Accelerated biological aging in breast cancer and risk for cognitive and physical complaints

乳腺癌的生物衰老加速以及认知和身体不适的风险

基本信息

  • 批准号:
    10551258
  • 负责人:
  • 金额:
    $ 39.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-01-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

Project summary Breast cancer is the most common cancer in women, with over two-hundred and sixty thousand new cases expected in the United States in 2018 alone. There are estimated to be more than 3 million breast cancer survivors in the US due to substantial advances in detection and treatment, with this number continuing to grow. However, treatments also increase risk for long-term and late toxicities, including effects on physical and cognitive function that interfere with quality of life. One possible explanation recently proposed is that the toxicity of cancer treatments may directly accelerate the aging process in some patients, leading to earlier onset of age-related symptoms such as cognitive complaints, fatigue, declines in physical function, and lasting pain. However, this hypothesis has not been rigorously tested in clinical populations. Our study will examine the effects of common breast cancer treatments as they relate to markers of biological aging, inflammation, and reports of physical and cognitive complaints in a prospective study of breast cancer patients assessed prior to and after exposure to chemotherapy and/or radiotherapy. The proposed study will leverage an existing NCI- funded cohort of women with early-stage breast cancer assessed before onset of adjuvant therapy with radiation (RT), chemotherapy (CT), or endocrine therapy and again after completion of RT and/or CT and at follow-up visits occurring 6-, 12-, and 18-month post-treatment, with serial blood specimens for plasma, DNA and RNA analyses. In this well characterized cohort of breast cancer survivors, we propose to add the assessment of markers of biological aging using existing collected specimens and add a new behavioral assessment at 7 years post treatment to 1) examine the effects of breast cancer treatments on the biological aging process, 2) test the relationship between accelerated biological aging and cognitive and physical complaints in breast cancer patients over the follow-up period, and 3) test whether inflammatory factors mediate the relationship between biological aging and cognitive and physical complaints.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JULIENNE E BOWER其他文献

JULIENNE E BOWER的其他文献

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{{ truncateString('JULIENNE E BOWER', 18)}}的其他基金

Improving Sleep Quality During the Transition to College
提高大学过渡期间的睡眠质量
  • 批准号:
    10444767
  • 财政年份:
    2022
  • 资助金额:
    $ 39.02万
  • 项目类别:
Improving Sleep Quality During the Transition to College
提高大学过渡期间的睡眠质量
  • 批准号:
    10623329
  • 财政年份:
    2022
  • 资助金额:
    $ 39.02万
  • 项目类别:
Accelerated biological aging in breast cancer and risk for cognitive and physical complaints
乳腺癌的生物衰老加速以及认知和身体不适的风险
  • 批准号:
    10320746
  • 财政年份:
    2020
  • 资助金额:
    $ 39.02万
  • 项目类别:
Accelerated biological aging in breast cancer and risk for cognitive and physical complaints
乳腺癌的生物衰老加速以及认知和身体不适的风险
  • 批准号:
    9888179
  • 财政年份:
    2020
  • 资助金额:
    $ 39.02万
  • 项目类别:
Accelerated biological aging in breast cancer and risk for cognitive and physical complaints
乳腺癌的生物衰老加速以及认知和身体不适的风险
  • 批准号:
    10077836
  • 财政年份:
    2020
  • 资助金额:
    $ 39.02万
  • 项目类别:
A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors
针对年轻乳腺癌幸存者行为症状的 III 期随机试验
  • 批准号:
    9315784
  • 财政年份:
    2016
  • 资助金额:
    $ 39.02万
  • 项目类别:
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patients
新诊断乳腺癌患者疲劳的生物行为预测因子
  • 批准号:
    8481524
  • 财政年份:
    2012
  • 资助金额:
    $ 39.02万
  • 项目类别:
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patients
新诊断乳腺癌患者疲劳的生物行为预测因素
  • 批准号:
    8631066
  • 财政年份:
    2012
  • 资助金额:
    $ 39.02万
  • 项目类别:
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patients
新诊断乳腺癌患者疲劳的生物行为预测因子
  • 批准号:
    8246261
  • 财政年份:
    2012
  • 资助金额:
    $ 39.02万
  • 项目类别:
Integrated Training in the Population, Behavioral, and Biomedical Sciences
人口、行为和生物医学科学综合培训
  • 批准号:
    8496072
  • 财政年份:
    2009
  • 资助金额:
    $ 39.02万
  • 项目类别:

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