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ACUTE OTITIS MEDIA--ADJUVANT THERAPY TO IMPROVE OUTCOME

ACUTE OTITIS MEDIA--ADJUVANT THERAPY TO IMPROVE OUTCOME
急性中耳炎——改善疗效的辅助治疗
批准号：
6246326
负责人：
Tasnee Chonmaitree
金额：
$2.71万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-06 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246326
关键词：
antibiotics antihistamines antiinflammatory agents bacterial disease child (0-11) clinical research clinical trials combination chemotherapy corticosteroids ear disorder chemotherapy exudate /transudate histamine human subject human therapy evaluation leukotrienes longitudinal human study otitis media pediatric pharmacology pediatrics relapse /recurrence virus diseases

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中文摘要
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英文摘要
Despite the availability for effective antibiotics for treatment of acute otitis media (AOM), treatment failures, persistent effusions and recurrences are common. We have previously shown that increased levels of inflammatory mediators such as histamine and leukotrienes in the middle ear fluids (MEFs) are associated with adverse clinical outcome of AOM. In this study, we will test whether adjuvant therapy aimed at counteracting histamine actions (antihistamine), and/or inhibiting formation of leukotrienes and other inflammtory substances (corticosteroid).
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Respiratory Tract Microbiota and Acute Otitis Media Development in Young Infants
Respiratory Tract Microbiota and Acute Otitis Media Development in Young Infants
PATHOGENESIS OF VIRUS-INDUCED ACUTE OTITIS MEDIA: GENETIC AND ENVIRONMENTAL
LONGITUDINAL STUDY OF ACUTE OTITIS MEDIA (AOM) DEVELOPMENT IN CHILDREN WITH
海外基金