ACUTE OTITIS MEDIA--ADJUVANT THERAPY TO IMPROVE OUTCOME

急性中耳炎——改善疗效的辅助治疗

• 批准号: 6246326
• 负责人: Tasnee Chonmaitree
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246326
• 关键词: antibiotics; antihistamines; antiinflammatory agents; bacterial disease; child (0-11); clinical research; clinical trials; combination chemotherapy; corticosteroids; ear disorder chemotherapy; exudate /transudate; histamine; human subject; human therapy evaluation; leukotrienes; longitudinal human study; otitis media; pediatric pharmacology; pediatrics; relapse /recurrence; virus diseases

Despite the availability for effective antibiotics for treatment of acute otitis media (AOM), treatment failures, persistent effusions and recurrences are common. We have previously shown that increased levels of inflammatory mediators such as histamine and leukotrienes in the middle ear fluids (MEFs) are associated with adverse clinical outcome of AOM. In this study, we will test whether adjuvant therapy aimed at counteracting histamine actions (antihistamine), and/or inhibiting formation of leukotrienes and other inflammtory substances (corticosteroid).

尽管有效的抗生素可用于治疗 急性中耳炎（AOM）、治疗失败、持续性积液和 复发是常见的。 我们之前已经证明， 炎症介质，如组胺和白三烯， 中耳积液（MEF）与不良临床结局相关， AOM。 在这项研究中，我们将测试是否辅助治疗， 对抗组胺作用（抗组胺剂），和/或抑制 白三烯和其他炎症物质的形成 （皮质类固醇）。