HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

HORNET 自主神经记录和刺激系统中心 (CARSS)

• 批准号: 10557002
• 负责人: Raja Edward Hitti
• 金额: $ 51.76万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557002
• 关键词: Address; Air; Algorithmic Software; Algorithms; Ally; Android; Architecture; Biochemical; Biological Markers; Blood; Bluetooth; Cellular Phone; Charge; Chemicals; Clinical; Clinical Research; Communication; Custom; Development; Diagnostic Equipment; Disease; Effectiveness; Electrocardiogram; Exhalation; Explosion; Face; Galaxy; Galvanic Skin Response; Glucose; Head; Individual; Lead; Mechanics; Medical Device; Medicine; Mind; Modality; Monitor; Operating System; Patients; Physical activity; Physiologic pulse; Physiological; Research Personnel; Respiration; Running; Sleep; Source; System; Tablets; Technology; Telemetry; Temperature; Testing; autonomic nerve; base; bioelectronics; clinical diagnostics; design; electric impedance; experience; flexibility; interest; mathematical ability; neuroregulation; open source; operation; sensor

Despite a wide-ranging interest in performing clinical research for bioelectronic medicine applications, there are no available open-architecture and open-source implantable systems for autonomic nerve stimulation and recording. As a result, clinical researchers face significant technical, regulatory, and financial hurdles in getting access to the implantable neuromodulation technologies that are required for performing these clinical studies. There are several clinical closed-loop implantable neuromodulation systems presently available and they have been helpful in supporting clinical research. However, in their current form, none are suitable for the bioelectronic medicine applications, as they lack key modules for accessing the autonomic nerves; moreover, many of them use closed architectures. To address this challenge, we propose to develop the mechanical modules for the implantable pulse generator (IPG) platform and external charger, which will be based on a flexible, open-architecture, and modular approach. Such flexibility will allow a significant degree of customization for different clinical indications, including open-loop and closed-loop IPG operation. The IPG modules will be designed for interfacing with a large selection of sensing and stimulation leads. Once the IPG and charger modules are developed, they will be subjected to the benchtop mechanical testing.

尽管对生物电子医学应用的临床研究有广泛的兴趣，但仍然存在