The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Admin Core

杰克逊实验室衰老组织绘图中心 (JAX-Sen TMC) - 管理核心

• 批准号: 10552966
• 负责人: Nadia A Rosenthal
• 金额: $ 82.87万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552966
• 关键词: Animals; Archives; Biological; Biological Assay; Cell Aging; Collaborations; Collection; Communication; Data; Data Analyses; Data Collection; Data Coordinating Center; Decision Making; Development; Doctor of Philosophy; Ensure; Fostering; Funding; Generations; Goals; Health; Human; Infrastructure; Laboratories; Leadership; Logistics; Maps; Monitor; Mus; Phenotype; Pilot Projects; Preparation; Protocols documentation; RLK5-associated protein phosphatase; Recommendation; Reporting; Resource Allocation; Resource Sharing; Resources; Risk Assessment; Sampling; Schedule; Services; Site; Technology; The Jackson Laboratory; Time; Tissue Sample; Tissues; United States National Institutes of Health; Work; base; cohort; collaborative environment; data quality; data sharing; data sharing networks; design; experience; human tissue; improved; meetings; member; operation; programs; senescence; success; synergism; technology development; tissue mapping; tool; virtual

PROJECT SUMMARY/ABSTRACT ADMINISTRATIVE CORE The objective of the Administrative Core is to provide scientific leadership and operational management of The Jackson Laboratory (JAX) Cellular Senescence Collaborative (JAX-Sen) Tissue Mapping Center (TMC) in support of SenNet goals to map cellular senescence and its associated secretory phenotype in healthy mouse tissues. The Administrative (Admin) Core will provide the infrastructure to support all communication, coordination, oversight and management functions of the proposed center through a Governing Committee (GC) comprised of all PIs and Core Leads, an experienced Program Manager, and outside guidance from NIH program officials as necessary. Through a thoughtful Leadership Plan, the Admin Core will provide the overall governance of JAX-Sen that ensures robust communication within JAX-Sen and with other SenNet TMCs (Aim 1). The Admin Core will organize and oversee regular scientific meetings to foster communication and synergy within and across JAX-Sen, and to nurture a strong, collaborative environment across JAX-Sen’s two project sites (The Jackson Laboratory and UConn Health), across JAX-Sen and KAPP-Sen, a SenNet-funded human Tissue Mapping Center also based at JAX and UConn Health, and across SenNet consortium stakeholders, namely the Technology Development Centers, other TMCs, the CODCC, the SenNet Steering Committee, and NIH program officials. Through a Tissue Mapping Center Coordination Plan, the Admin Core will also coordinate the development of animal cohorts, collection of mouse tissue samples, data generation, data analysis and resource and data sharing within JAX-Sen (Aim 2). The Admin Core will provide scientific and administrative oversight of the Biological Analysis and Data Analysis Cores. This oversight, administered by the Program Manager, will include risk assessment and decision-making, project management, timely preparation of reports, and data quality reviews at regularly scheduled meetings with Core Leads. Through a Network Coordination Plan, The Admin Core will also coordinate collaboration and communication with all members of SenNet to optimize resource sharing and contributions towards overarching programmatic goals (Aim 3). The Admin Core will collaborate with other SenNet sites and NIH program officials to design or improve Network operations and implement protocols. The Admin Core will work with the CODCC to optimize strategies for data collection and analysis, and to facilitate public access to SenNet data through the CODCC. The Admin Core will coordinate plans for collaborating with other murine and human TMCs on topics including but not limited to SOPs, assay protocols and data analysis, and pilot projects. The Admin Core will also oversee creative, synergy-generating collaborative activities that make use of JAX-Sen’s (and JAX’s) unique resources, expertise and infrastructure.

项目概要/抽象行政核心 行政核心的目标是对行政核心进行科学领导和业务管理， 杰克逊实验室（JAX）细胞衰老协作（JAX-Sen）组织绘图中心（TMC） 支持SenNet目标以绘制健康小鼠中细胞衰老及其相关分泌表型 组织中行政（管理）核心将提供支持所有通信的基础设施， 通过一个理事委员会履行拟议中心的协调、监督和管理职能 (GC)由所有PI和核心主管、经验丰富的项目经理以及来自 国家卫生研究院的官员。通过深思熟虑的领导计划，管理核心将提供 JAX-Sen的整体治理，确保JAX-Sen内部以及与其他SenNet TMC之间的健壮通信 (Aim 1）。管理核心将组织和监督定期科学会议，以促进沟通， 在JAX-Sen内部和跨JAX-Sen的协作，并在JAX-Sen的两个 项目站点（杰克逊实验室和康州大学健康），跨JAX-Sen和KAPP-Sen，一个SenNet资助的 人类组织绘图中心也位于JAX和UConn Health，并跨越SenNet联盟 利益相关者，即技术开发中心、其他TMC、CODCC、SenNet指导 委员会和NIH项目官员。通过组织标测中心协调计划， 还将协调动物队列的开发，小鼠组织样本的收集，数据生成， JAX-Sen中的数据分析和资源与数据共享（目标2）。管理核心将提供科学的 以及对生物分析和数据分析核心的行政监督。这一疏忽， 由项目经理，将包括风险评估和决策，项目管理，及时 准备报告，并在与核心领导定期安排的会议上进行数据质量审查。通过 网络协调计划，管理核心还将协调与所有 SenNet成员优化资源共享和对总体方案目标的贡献 (Aim 3）。管理核心将与其他SenNet站点和NIH项目官员合作， 网络操作和执行协议。管理核心将与CODCC合作，优化战略 数据收集和分析，并促进公众通过CODCC访问SenNet数据。管理员 核心将协调计划，与其他鼠和人类TMC合作的主题，包括但不限于 标准操作程序、分析方案和数据分析以及试点项目。管理核心还将监督创意， 利用JAX-Sen（和JAX）独特的资源、专业知识 和基础设施