The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Admin Core

杰克逊实验室衰老组织绘图中心 (JAX-Sen TMC) - 管理核心

• 批准号: 10683386
• 负责人: Nadia A Rosenthal
• 金额: $ 53.29万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683386
• 关键词: Animals; Archives; Biological; Biological Assay; Cell Aging; Collaborations; Collection; Communication; Creativeness; Data; Data Analyses; Data Collection; Data Coordinating Center; Decision Making; Development; Doctor of Philosophy; Ensure; Fostering; Funding; Generations; Goals; Health; Human; Infrastructure; Laboratories; Leadership; Logistics; Maps; Monitor; Mus; Phenotype; Pilot Projects; Preparation; Protocols documentation; RLK5-associated protein phosphatase; Recommendation; Reporting; Resource Allocation; Resource Sharing; Resources; Risk Assessment; Sampling; Schedule; Services; Site; The Jackson Laboratory; Tissue Sample; Tissues; United States National Institutes of Health; Work; cohort; collaborative environment; data quality; data sharing; design; experience; human tissue; improved; meetings; member; operation; programs; senescence; success; synergism; technology development; technology platform; tissue mapping; tool; virtual

PROJECT SUMMARY/ABSTRACT ADMINISTRATIVE CORE The objective of the Administrative Core is to provide scientific leadership and operational management of The Jackson Laboratory (JAX) Cellular Senescence Collaborative (JAX-Sen) Tissue Mapping Center (TMC) in support of SenNet goals to map cellular senescence and its associated secretory phenotype in healthy mouse tissues. The Administrative (Admin) Core will provide the infrastructure to support all communication, coordination, oversight and management functions of the proposed center through a Governing Committee (GC) comprised of all PIs and Core Leads, an experienced Program Manager, and outside guidance from NIH program officials as necessary. Through a thoughtful Leadership Plan, the Admin Core will provide the overall governance of JAX-Sen that ensures robust communication within JAX-Sen and with other SenNet TMCs (Aim 1). The Admin Core will organize and oversee regular scientific meetings to foster communication and synergy within and across JAX-Sen, and to nurture a strong, collaborative environment across JAX-Sen’s two project sites (The Jackson Laboratory and UConn Health), across JAX-Sen and KAPP-Sen, a SenNet-funded human Tissue Mapping Center also based at JAX and UConn Health, and across SenNet consortium stakeholders, namely the Technology Development Centers, other TMCs, the CODCC, the SenNet Steering Committee, and NIH program officials. Through a Tissue Mapping Center Coordination Plan, the Admin Core will also coordinate the development of animal cohorts, collection of mouse tissue samples, data generation, data analysis and resource and data sharing within JAX-Sen (Aim 2). The Admin Core will provide scientific and administrative oversight of the Biological Analysis and Data Analysis Cores. This oversight, administered by the Program Manager, will include risk assessment and decision-making, project management, timely preparation of reports, and data quality reviews at regularly scheduled meetings with Core Leads. Through a Network Coordination Plan, The Admin Core will also coordinate collaboration and communication with all members of SenNet to optimize resource sharing and contributions towards overarching programmatic goals (Aim 3). The Admin Core will collaborate with other SenNet sites and NIH program officials to design or improve Network operations and implement protocols. The Admin Core will work with the CODCC to optimize strategies for data collection and analysis, and to facilitate public access to SenNet data through the CODCC. The Admin Core will coordinate plans for collaborating with other murine and human TMCs on topics including but not limited to SOPs, assay protocols and data analysis, and pilot projects. The Admin Core will also oversee creative, synergy-generating collaborative activities that make use of JAX-Sen’s (and JAX’s) unique resources, expertise and infrastructure.

项目摘要/抽象管理核心 行政核心的目标是提供科学的领导和业务管理 杰克逊实验室(JAX)细胞衰老协作(JAX-SEN)组织映射中心(TMC) Sennet Goals支持定位健康小鼠的细胞衰老及其相关的分泌表型 纸巾。管理(管理)核心将提供支持所有通信的基础设施， 通过理事委员会协调、监督和管理拟建中心的职能 (GC)由所有PI和核心主管、一名经验丰富的项目经理以及来自 NIH项目官员如有必要。通过深思熟虑的领导计划，管理核心将提供 对JAX-Sen的全面治理，确保JAX-Sen内部以及与其他Sennet TMC之间的可靠通信 (目标1)。行政核心将组织和监督定期的科学会议，以促进沟通和 JAX-Sen内部和跨JAX-Sen的协同，并在JAX-Sen和JAX-Sen之间培育强大的协作环境 项目网站(杰克逊实验室和康涅狄格州大学健康中心)，横跨JAX-Sen和Kapp-Sen，一个由Sennet资助的 人类组织测绘中心也设在JAX和康涅狄格州大学健康中心，并跨Sennet联盟 利益攸关方，即技术开发中心、其他技术管理委员会、CODCC、SENet指导 委员会和NIH项目官员。通过组织测绘中心协调计划，管理核心 还将协调动物队列的发展、小鼠组织样本的收集、数据生成、 在JAX-SEN内进行数据分析以及资源和数据共享(目标2)。管理核心将提供科学的 以及对生物分析和数据分析核心的行政监督。这一监督，管理 由项目经理负责，将包括风险评估和决策、项目管理、及时 准备报告，并在与核心领导的定期会议上进行数据质量审查。通过一个 网络协调计划，管理核心还将协调与所有 Sennet成员优化资源共享和对总体方案目标的贡献 (目标3)。管理核心将与其他Sennet站点和NIH计划官员合作设计或改进 网络操作和实施协议。管理核心将与CODCC合作以优化策略 用于数据收集和分析，并便利公众通过CODCC获取SENet数据。《管理员》 CORE将协调与其他小鼠和人类TMC合作的计划，主题包括但不限于 到标准操作规程、化验方案和数据分析，以及试点项目。管理核心还将监督创意、 协同生成协作活动，利用JAX-Sen(和JAX)的独特资源、专业知识 和基础设施。