Epigenetic Differences in Stress-Related Genes in Transgender Minorities

变性人少数民族应激相关基因的表观遗传差异 慢性下腰痛(CLBP)在美国与高昂的成本相关，与CLBP一起生活可能会有 对生活质量的负面影响。自认为是少数族裔的人往往因慢性疾病而得不到足够的治疗 疼痛状况，并报告更严重的CLBP和禁用。然而，尽管有既定的性行为 在慢性疼痛的表现和治疗上的差异，很少有工作调查慢性疼痛的负担 性别少数群体，包括变性人(变性)男性和女性的痛苦。在这里，我们提议招聘 变性人(N=15)和变性人(N=15)目前正在进行的一项调查DNA种族差异的研究 黑人和白人CLBP患者的甲基化(DNaM)和基因表达，重点是应激 暴露在环境中。变性人，通常是当地的少数族裔，每天都面临着复杂的问题 与种族、性别和慢性疼痛有关的压力、耻辱和歧视。因此，这一人口的增加 目前的研究将允许对性别认同及其对dNaM和基因的影响进行新的调查 表情。根据特殊利益通知(NOD-OD-22-032)，我们将增加性别少数 一项正在进行的研究(R01AR079178)的参与者(即变性人)，以允许首次探索性别 同一性对应激相关dNaM和基因表达的影响。

Epigenetic Differences in Stress-Related Genes in Transgender Minorities Chronic low back pain (CLBP) is associated with substantial costs in the US and living with CLBP can have a negative impact on quality of life. Individuals who identify as racial minorities are often undertreated for chronic pain conditions and report more severe and disabling CLBP. However, whereas there are established sex differences in the expression and treatment of chronic pain, little work has investigated the burden of chronic pain in gender minorities including transgender (trans) men and women. Here we are proposing to recruit transmen (N=15) and transwomen (N=15) to a current study investigating the racial differences in DNA methylation (DNAm) and gene expression in Black and White CLBP sufferers, with an emphasis on stressful environmental exposures. Trans individuals, often racial minorities in the local area, face compounded daily stress, stigma and discrimination related to race, gender and chronic pain. Thus, the addition of this population to the current study will allow a novel investigation of gender identity and the impact on DNAm and gene expression. In line with the Notice of Special Interest (NOD-OD-22-032), we will be adding gender minority participants (i.e. transgender) to an ongoing study (R01AR079178) to allow for the first exploration of gender identity effects on stress-related DNAm and gene expression.