Immune Dysfunction in HIV + Opiod Users
HIV阿片使用者的免疫功能障碍
基本信息
- 批准号:10552153
- 负责人:
- 金额:$ 15.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-15 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAddressAdultAffinityAnalgesicsAntibodiesAntibody FormationAntibody ResponseAntigensAreaB-LymphocytesBlood specimenBrainCD4 Positive T LymphocytesCell CountCell MaturationCellsCessation of lifeCharacteristicsChronicCitiesClinicCoupledDangerousnessDataData SetDefectDependenceDevelopmentEpidemicEvaluationExhibitsFailureFeasibility StudiesFlow CytometryFrequenciesFunctional disorderFutureGenerationsGenetic TranscriptionGenomic approachHIVHIV InfectionsHIV SeronegativityHelper-Inducer T-LymphocyteHumanImmuneImmune System DiseasesImmune responseImmune systemImmunityImmunocompetenceImmunoglobulin Somatic HypermutationImmunologicsImpairmentIn VitroIncidenceInflammationInflammatoryInfluenzaInfluenza A Virus, H1N1 SubtypeInfluenza vaccinationInterleukin-2InterventionLeadLymphoidMemoryMemory B-LymphocyteMorphineNucleic AcidsOpiate AddictionOpioidOpioid ReceptorParticipantPatientsPeripheralPersonal SatisfactionPersonsPhenotypePlasmaPlasmablastPlayPopulationPropertyReceptor SignalingRecoveryResearchResolutionSeasonsSerologySignal TransductionStructure of germinal center of lymph nodeSubgroupSurfaceT-Lymphocyte SubsetsTechnologyTestingUniversitiesVaccinationVaccine AntigenVaccineeVaccinesViraladdictionantagonistbasedelta opioid receptordrug abuserflufunctional disabilitygenomic platformimmune activationimmune functionindexinginflammatory markerinfluenza infectioninfluenza virus vaccineinsightinterestneglectnovelopioid epidemicopioid injectionopioid useopioid userperipheral bloodprescription opioidpreventprogramsreceptorrecruitresponders and non-respondersresponseseasonal influenzasingle cell technologytherapeutic vaccinetooltranscriptomicstrivalent influenza vaccinevaccine responsevaccine-induced antibodies
项目摘要
This Competitive Revision application for 2019 Novel Coronavirus research is related to the current grant
Immune Dysfunction in HIV+ Opioid Users (DA051202) which is investigating influenza vaccine responses in
people with HIV (PWH) who have opioid use disorder (OUD). The premise for the funded grant is that HIV
infection impairs immunity with evidence of persisting immune perturbations even after durable virologic
control. Opioids are immunosuppressive and abuse through prescription or injection can be damaging to the
immune system and prove to be specially harmful in PWH. Our central hypothesis in the parent grant is that
chronic opioid use by PWH (HIV+OP+) blunts the immune response and impairs the generation of influenza
vaccine induced immune response. Our plan is to investigate participants in 4 groups (HIV+OP+, HIV-OP+,
HIV+OP- and HIV-OP-) before and after influenza vaccine administered as a clinical trial. The project funding
started in the midst of the COVID-19 pandemic that has resulted in global morbidity and mortality. The
clinical course of SARS-CoV-2 infection is highly variable, ranging from asymptomatic to severe disease
resulting in full recovery, death, or persistent symptoms described as PASC (post acute sequalae of COVID-
19) which can affect one or more organs such as the brain, heart, lung, gut, kidneys, or musculosleletal
system. The immune response generated by SARs COV-2 is dynamic, involves innate and adaptive
immunity and evolves with the stage of the disease. Antibodies to the spike protein's receptor binding domain
corelate with neutralizing activity and form the basis of judging effectiveness of current vaccines as well as
monoclonal Ab therapy. Duration of Ab in the host following SARS CoV-2 infection or vaccination is unknown
and there are gaps in our knowledge about the role of T cells in Ab persistence or emergence of viral
variants. It is also unknown if COVID-19 causes detrimental effects on immunity and if this effect varies
depending on the host's immune competence, with the greatest impact in an immunocompromised host.
These issues are relevant for the HIV+OP+ population and need to be investigated. While Ab formation to
SARS CoV 2 is dependent upon infection or vaccination, T cell memory for SARS CoV2 has been shown to
pre-exist in approximately 50% of the general population due to cross reactive immunity induced by Common
Cold Corona viruses. Such SARS-CoV-2 specific memory T cells are considered to be beneficial to the host,
affording protection from infection, or reduction in disease severity, particularly in the face of absent or
waning humoral immunity. Despite the disruption in operations and regulatory delays due to COVID-19 our
project has been initiated, and we feel that a revision at this juncture to incorporate questions related to
SARS CoV-2 are timely and important. In this revision we are proposing to incorporate a pilot study of SARS-
CoV-2 seroprevalence and T cell memory in the context of original aims in the HIV+OP+ and the other 3
groups (HIV-OP+, HIV+OP- and HIV-OP-) being investigated for flu vaccine induced immune responses.
2019年新型冠状病毒研究竞争性修订申请与当前拨款有关
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Savita Pahwa其他文献
Savita Pahwa的其他文献
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{{ truncateString('Savita Pahwa', 18)}}的其他基金
Immune correlates of LTBI in HIV-exposed infants
HIV 暴露婴儿 LTBI 的免疫相关性
- 批准号:
10543401 - 财政年份:2019
- 资助金额:
$ 15.35万 - 项目类别:
Immunity and HIV persistence in perinatal HIV infection
围产期 HIV 感染中的免疫和 HIV 持续性
- 批准号:
9211649 - 财政年份:2016
- 资助金额:
$ 15.35万 - 项目类别:
Immunity and HIV persistence in perinatal HIV infection
围产期 HIV 感染中的免疫和 HIV 持续性
- 批准号:
9302666 - 财政年份:2016
- 资助金额:
$ 15.35万 - 项目类别:
Antibody Responses in Aging SIV Infected Monkeys
感染 SIV 的衰老猴子的抗体反应
- 批准号:
9120783 - 财政年份:2015
- 资助金额:
$ 15.35万 - 项目类别:
Immune Activation in Virologically Suppressed Indian HIV-infected Patients
病毒学受到抑制的印度艾滋病毒感染者的免疫激活
- 批准号:
8540075 - 财政年份:2013
- 资助金额:
$ 15.35万 - 项目类别:
Immune Activation in Virologically Suppressed Indian HIV-infected Patients
病毒学受到抑制的印度艾滋病毒感染者的免疫激活
- 批准号:
8728729 - 财政年份:2013
- 资助金额:
$ 15.35万 - 项目类别:
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