Imaging-based Indentification of Premature Ventricular Contraction-mediated

基于成像的室性早搏介导的识别

• 批准号: 10553428
• 负责人: Yuchi Han
• 金额: $ 48.62万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-08 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553428
• 关键词: Ablation; Address; Ambulatory Monitoring; Animal Model; Anti-Arrhythmia Agents; Arrhythmia; Benign; Biological Markers; Breathing; Cardiac Output; Cardiomyopathies; Catheters; Characteristics; Chest Pain; Clinical; Clinical Trials; Complex; Coupling; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; EFRAC; Echocardiography; Electrocardiogram; Electrophysiology (science); Foundations; Frequencies; Gadolinium; General Population; Generations; Goals; Heart; Heart failure; Image; Image Enhancement; Imaging Techniques; Impairment; Individual; Knowledge; Lead; Left; Left Ventricular Ejection Fraction; Left Ventricular Function; Longitudinal Studies; Magnetic Resonance Imaging; Mediating; Medical center; Modeling; Morphology; Muscle function; Myocardial; Myocardial tissue; Myocardium; Normal tissue morphology; Pathologic; Patients; Pennsylvania; Performance; Pharmaceutical Preparations; Prevalence; Prevention; Procedures; Relaxation; Reporting; Research; Risk; Risk Factors; Sinus; Site; Sudden Death; Syncope; Techniques; Testing; Time; Tissues; Toxic effect; Universities; University Hospitals; Ventricular; Ventricular Function; Ventricular Premature Complexes; base; cardiac magnetic resonance imaging; clinical practice; cohort; diagnostic accuracy; diagnostic criteria; diagnostic tool; diagnostic value; extracellular; follow-up; heart function; hemodynamics; human subject; improved; noninvasive diagnosis; novel; parametric imaging; predictive modeling; prospective; structural heart disease; tissue mapping; voltage

The cause of premature ventricular contraction (PVC)-mediated cardiomyopathy is unknown. The estimated prevalence of PVCs is high in the general population with reported 40-75% on ambulatory monitoring. PVCs are often considered benign, but may be associated with increased risk of sudden death or associated with chest pain, syncope, or heart failure, especially when structural heart disease is present. A long-term study on patients with relatively low PVC burden showed no difference in survival. However, high PVC burden is associated with lower left ventricular function in patients with and without structural disease. Unfortunately, suppressing PVCs by ablation or antiarrhythmic medications do not always improve ventricular function in patients. Animal models have showed that bigeminy pacing near the apex could induce a cardiomyopathy that is reversible without myocardial structural changes. However, these models do not explain the lack of cardiomyopathy development in some human subjects with frequent PVCs such as bigeminy. We propose that frequent pathologic PVCs lead to PVC- induced cardiomyopathy in normal hearts and PVC-worsened cardiomyopathy in hearts with abnormal tissue characteristics. The pathologic versus benign PVCs can be determined by LV function during PVC, which is quantitatively assessed using advanced real-time cardiac magnetic resonance imaging (MRI) techniques. LV function during PVC is likely a result of a combination of factors including PVC site of origin, coupling interval, and conduction time through the myocardium. Together with tissue characterization of the ventricular myocardium by cardiac MRI and electroanatomic voltage mapping, this proposal seeks to identify hemodynamic and structural features in PVC-induced or worsened cardiomyopathy in order to better select patients for treatment.

室性早搏（PVC）介导的心肌病的病因尚不清楚。 据估计，普通人群中 PVC 的患病率很高，据报道，其患病率为 40-75% 动态监测。 PVC 通常被认为是良性的，但可能与 猝死或与胸痛、晕厥或心力衰竭相关的风险增加， 尤其是当存在结构性心脏病时。一项针对患有相对疾病的患者的长期研究 低 PVC 负荷显示生存率没有差异。然而，高 PVC 负荷与 有或没有结构性疾病的患者左心室功能较低。很遗憾， 通过消融或抗心律失常药物抑制室性早搏并不总能改善心室 患者的功能。动物模型表明，在心尖附近的二联律起搏可以 诱发可逆性心肌病，无需心肌结构改变。然而， 这些模型不能解释某些人类受试者缺乏心肌病的发展 经常出现 PVC，例如二联律。我们认为频繁的病理性 PVC 会导致 PVC- 正常心脏中诱发的心肌病和患有 PVC 的心脏中诱发的心肌病 异常的组织特征。病理性与良性 PVC 可以通过 LV 来确定 PVC 期间的功能，使用先进的实时心脏功能进行定量评估 磁共振成像（MRI）技术。 PVC 期间的 LV 功能可能是以下原因的结果 多种因素的组合，包括 PVC 来源、耦合间隔和传导时间 通过心肌。连同心室心肌的组织特征 心脏 MRI 和电解剖电压图，该提案旨在确定血流动力学 和 PVC 诱发或恶化的心肌病的结构特征，以便更好地选择 患者接受治疗。

项目成果

Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement.

• DOI: 10.1016/j.jcmg.2022.10.021
• 发表时间: 2023-05
• 期刊: JACC-CARDIOVASCULAR IMAGING
• 影响因子: 14
• 作者: Vidula, Mahesh K.;Rajewska-Tabor, Justyna;Cao, J. Jane;Kang, Yu;Craft, Jason;Mei, Winifred;Chandrasekaran, Preethi S.;Clark, Daniel E.;Poenar, Ana-Maria;Gorecka, Miroslawa;Malahfji, Maan;Cowan, Eilidh;Kwan, Jennifer M.;Reinhardt, Samuel W.;Al-Tabatabaee, Sarah;Doeblin, Patrick;Villa, Adriana D. M.;Karagodin, Ilya;Alvi, Nazia;Christia, Panagiota;Spetko, Nicholas;Cassar, Mark Philip;Park, Christine;Nambiar, Lakshmi;Turgut, Alper;Azad, Mahan Roosta;Lambers, Moritz;Wong, Timothy C.;Salerno, Michael;Kim, Jiwon;Elliott, Michael;Raman, Betty;Neubauer, Stefan;Tsao, Connie W.;LaRocca, Gina;Patel, Amit R.;Chiribiri, Amedeo;Kelle, Sebastian;Baldassarre, Lauren A.;Shah, Dipan J.;Hughes, Sean G.;Tong, Matthew S.;Pyda, Malgorzata;Simonetti, Orlando P.;Plein, Sven;Han, Yuchi
• 通讯作者: Han, Yuchi

Cardiovascular magnetic resonance characterization of rheumatic mitral stenosis: findings from three worldwide endemic zones.

• DOI: 10.1186/s12968-022-00853-5
• 发表时间: 2022-04-07
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Vidula MK;Xu Z;Xu Y;Alturki A;Reddy BN;Kini P;Alberto-Delgado AL;Jacob R;Chen T;Ferrari VA;Sierra-Galan LM;Chen Y;Viswamitra S;Han Y
• 通讯作者: Han Y

Lipomatous metaplasia prolongs repolarization and increases repolarization dispersion within post-infarct ventricular tachycardia circuit cites.

• DOI: 10.1093/europace/euac222
• 发表时间: 2023-02-16
• 期刊: EUROPACE
• 影响因子: 6.1
• 作者: Xu, Lingyu;Zahid, Sohail;Khoshknab, Mirmilad;Moss, Juwann;Berger, Ronald D.;Chrispin, Jonathan;Callans, David;Marchlinski, Francis E.;Zimmerman, Stefan L.;Han, Yuchi;Desjardins, Benoit;Trayanova, Natalia;Nazarian, Saman
• 通讯作者: Nazarian, Saman

Right Ventricular Global Longitudinal Strain as a Predictor of Acute and Early Right Heart Failure Post Left Ventricular Assist Device Implantation.

• DOI: 10.1097/mat.0000000000001467
• 发表时间: 2022-03-01
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Liang LW;Jamil A;Mazurek JA;Urgo KA;Wald J;Birati EY;Han Y
• 通讯作者: Han Y

Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity With Chest Radiation.

• DOI: 10.3389/fcvm.2022.867479
• 发表时间: 2022
• 期刊: Frontiers in cardiovascular medicine
• 影响因子: 3.6