IGF::OT::IGF STEVEN YOUNG CONSULTING MEDICINAL CHEMISTRY CONSULTANT SUPPORT

IGF::OT::IGF STEVEN YOUNG 咨询药物化学顾问支持

• 批准号: 10551094
• 负责人: STEVEN YOUNG
• 金额: $ 3.4万
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2022-02-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551094
• 关键词: Address; Area; Chemical Structure; Chemistry; Clinical Research; Clinical Trials; Consult; Contractor; Contracts; Data; Development; Electronic Mail; Feedback; Hour; Individual; Investigational Drugs; Lead; Methodology; Pharmaceutical Chemistry; Pharmaceutical Preparations; Preparation; Process; Reporting; Research Contracts; Role; Services; Strategic Planning; Teleconferences; Telephone; Testing; Time; United States National Institutes of Health; Visit; Work; design; drug development; drug discovery; lead optimization; meetings; member; preclinical safety; programs; symposium

The Contractor shall provide this support while serving on NIH BPN Lead Development Teams. Lead Development Teams (LDT) meet for approximately two hours every one to two weeks via teleconference and each LDT project may require between three and ten hours weekly, inclusive of meeting and preparation time. The Contractor is expected to provide support services in a collaborative way. Lead Development Teams the Contractor is assigned to may work on a number of projects in the exploratory through preclinical safety stages. Some projects may proceed to investigational new drug (IND) and clinical trial stages. The Contractor shall provide consulting support services to the NIH Blueprint Neurotherapeutics Network in the area of Medicinal Chemistry Medicinal chemistry consultants will be expected to provide senior-level medicinal chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the medicinal chemistry consultant may include but is not limited to the following responsibilities and tasks: • Offer input on project milestones, target product profiles, and testing funnels • Provide feedback on chemical structures and processes proposed by a chemistry service contractor for each round of SAR • Evaluate SAR data on a weekly or biweekly basis. • Medicinal chemistry consultant may be asked to evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. • Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. • Collaborate on design of investigative studies in support of NIH drug discovery and development projects. • Accompany NIH staff or visit, at BPN staff request, Contract Research Organizations [CRO] under contract to BPN. Inspect facilities and discuss appropriateness of CRO proposed methodology. Submit trip reports to BPN staff. • Facilitate Lead Development Team discussions via telephone and email regarding assigned drug medicinal chemistry.

承包商应在NIH BPN领导开发团队服务期间提供此支持。领导开发团队（LDT）每一到两周通过电话会议召开大约两个小时的会议，每个LDT项目每周可能需要三到十个小时，包括会议和准备时间。