Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

动脉粥样硬化多种族研究 (MESA) 是一项针对动脉粥样硬化的相关性、预测因素和进展的研究 45-84 岁男性和女性不同人群样本中的亚临床心血管疾病 (CVD) 基线时没有临床心血管疾病证据。在 MESA 的初始资助期间，有 6,814 名参与者 2000 年至 2002 年期间从六个现场中心招募并检查亚临床冠心病的证据 动脉粥样硬化，使用计算机断层扫描、心脏 MRI、颈动脉超声、血流介导的肱动脉 扩张、桡动脉张力测量、踝肱指数测量和视网膜摄影。一些 其他变量包括腹主动脉 CT、颈动脉 MRI、心脏 MRI 标记，用于测量区域性 心肌功能；已建立的和假定的实验室风险标记；社会经济、心理、 行为和环境特征；并在 MESA 子集中评估遗传变异 队列。在随后的五次检查中重复了选定部件的检查 大约 16 年以来，该队列一直被持续跟踪临床 CVD 事件 基线检查。 该研究将继续支持 NHLBI 合同之外资助的深入辅助研究。 这些研究将在操作上整合到主要研究中，并且数据将在整个研究中共享 根据当前的 MESA 和 NIH 数据共享政策，“MESA Suite”研究。该研究的数据将提供给 感兴趣的调查人员通过明确的流程鼓励最大限度地利用数据，同时保护 参与者保密。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.