Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

任务领域 A 应包括队列成员的年度随访、临床事件调查、研究操作以及数据分析和稿件撰写。

• 批准号: 10329687
• 负责人: Steven Shea
• 金额: $ 38.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-19 至 2021-12-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329687
• 关键词: Abdomen; Address; Ancillary Study; Ankle; Area; Behavioral; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Collaborations; Collection; Contracts; Coronary Arteriosclerosis; Data; Data Analyses; Disease; Event; Fostering; Functional disorder; Funding; Goals; Investigation; Laboratories; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Mediating; Multi-Ethnic Study of Atherosclerosis; Myocardial; National Heart, Lung, and Blood Institute; Participant; Photography; Policies; Population Heterogeneity; Process; Research Personnel; Retina; Risk Factors; Risk Marker; Sampling; Subgroup; Ultrasonography; United States National Institutes of Health; Woman; Writing; X-Ray Computed Tomography; aged; brachial artery; clinical examination; cohort; follow-up; genetic variant; indexing; interest; member; men; operation; population based; predict clinical outcome; psychologic; radial artery; recruit; response; socioeconomics; tonometry

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.

动脉粥样硬化多民族研究（MESA）是一项研究动脉粥样硬化相关因素、预测因素和进展的研究