Myo-inositol regulation of myelination in development and hypoxic newborn brain injury

肌醇对发育中髓鞘形成和缺氧新生儿脑损伤的调节

• 批准号: 10553457
• 负责人: SARAH E RAISSI
• 金额: $ 3.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10553457
• 关键词: Ablation; Address; Adult; Award; Biological Assay; Biology; Biosensor; Brain Injuries; CRISPR/Cas technology; Cell Count; Cell physiology; Cells; Chronic; Coculture Techniques; Cognitive deficits; Data; Defect; Development; Developmental Disabilities; Diffuse; Electron Microscopy; Environment; Event; Growth; Human; Human Milk; Hypoxia; Hypoxic Brain Damage; Image; Impairment; In Vitro; Injury; Inositol; Knock-out; Knockout Mice; Length; Life; Mass Spectrum Analysis; Measures; Mediating; Membrane; Motor; Mus; Myelin; Myelin Sheath; Neonatal; Neuraxis; Neurologic; Neurons; Newborn Infant; Nutraceutical; Oligodendroglia; Oxygen; Parents; Pathway interactions; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Premature Infant; Recovery of Function; Regulation; Signal Transduction; Supplementation; Testing; Therapeutic; Thick; Walking; Wild Type Mouse; cognitive function; conditional knockout; deprivation; experimental study; extracellular; gain of function; hypoxia neonatorum; improved; in vivo; insight; loss of function; motor deficit; mouse model; myelination; neonatal brain; neonatal mice; nervous system disorder; newborn brain injury; novel; nutritional supplementation; object recognition; postnatal; prenatal; repaired; sugar; uptake; white matter damage; white matter injury

Project Summary No change from parent award.

项目摘要 与家长奖励没有变化。

项目成果

Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination.

• DOI: 10.1016/j.neuron.2021.02.003
• 发表时间: 2021-04-21
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Pease-Raissi SE;Chan JR
• 通讯作者: Chan JR